Impact of blend properties on die filling during tableting
Publication date: Available online 11 August 2018Source: International Journal of PharmaceuticsAuthor(s): B. Van Snick, W. Grymonpré, J. Dhondt, K. Pandelaere, G. Di Pretoro, J.P. Remon, T. De Beer, C. Vervaet, V. VanhoorneAbstractBased on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying paddle speed and turret speed. The tablet weight variability was determined of 20 grab samples consisting of each 20 tablets. Additionally, the bulk residence time, ejection force, pre-compression displacement, main compression force, ...
Source: International Journal of Pharmaceutics - August 11, 2018 Category: Drugs & Pharmacology Source Type: research
Mucosal delivery systems of antihypertensive drugs: A practical approach in general practice.
Authors: Bialy LP, Wojcik C, Mlynarczuk-Bialy I
Abstract
Patients who are unable to receive oral medication (p.o.) are a major problem in outpatient settings, especially in home health care systems. Mucosal administration of drugs offers an alternative to the oral route, especially when the parenteral mode cannot be used. There are three main pathways of mucosal administration: sublingual/buccal, intranasal and rectal. We discuss the possibility of mucosal delivery of antihypertensive drugs. Perindopril arginine and Amlodipine besylate are registered in the EU as orodispersible tablets for oromucosal deliv...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - May 18, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
A case report of apical aneurysms and myocardial perfusion deficit with myocardial necrosis due to hypertrophic cardiomyopathy
We present a relatively rare case of HCM patients with apical aneurysms, accompaning by myocardial necrosis markers increased due to ventricular muscle stress increases, rather than obstructive coronary artery disease.
Interventions:
The patient was prescribed aspirin, metoprolol tartrate, perindopril, and atorvastatin and was strongly advised to quit cigarettes and reduce weight.
Outcomes:
Follow-up at half a year turned out well.
Lessons:
LGE with a notable progression by ECG and SPECT along with an increase in myocardial necrosis markers in HCM patients with apical aneurysms, as was noted in the present case, i...
Source: Medicine - May 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
In Vitro Assessment of Nasal Insufflation of Comminuted Drug Products Designed as Abuse Deterrent Using the Vertical Diffusion Cell.
In this study, a vertical diffusion cell (VDC) was used to evaluate polyethylene oxide (PEO)-based tablets manipulated by three different forces. The commercially available products Oxycontin®, an ADF, Opana®, and metoprolol tartrate tablet formulations made in our laboratory were studied. Particle size distribution and percent recovery of manipulated tablets were measured. Grinding produced the lowest recovery and the smallest particle size distribution. Drug release was examined using a VDC by placing the dry comminuted particles on an enclosed wetted cellulose membrane. Dispensing dry particles on a VDC is atypical bu...
Source: AAPS PharmSciTech - March 26, 2018 Category: Drugs & Pharmacology Authors: Boyce H, Smith D, Byrn S, Saluja B, Qu W, Gurvich VJ, Hoag SW Tags: AAPS PharmSciTech Source Type: research
When drugs plasticize film coatings: Unusual formulation effects observed with metoprolol and Eudragit RS
Publication date: 25 March 2018 Source:International Journal of Pharmaceutics, Volume 539, Issues 1–2 Author(s): Youness Karrout, Florence Siepmann, Youcef Benzine, Laurent Paccou, Yannick Guinet, Alain Hedoux, Juergen Siepmann Metoprolol tartrate and metoprolol free base loaded pellet starter cores were coated with Eudragit RS, plasticized with 25% triethyl citrate (TEC). The initial drug loading and coating level were varied from 10 to 40 and 0 to 20%, respectively. Drug release was measured in 0.1 N HCl and phosphate buffer pH 7.4. The water uptake and swelling kinetics, mechanical properties and TEC leachi...
Source: International Journal of Pharmaceutics - February 27, 2018 Category: Drugs & Pharmacology Source Type: research
The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets
Publication date: 25 April 2018 Source:International Journal of Pharmaceutics, Volume 541, Issues 1–2 Author(s): Jeroen Van Renterghem, Heleen Dhondt, Glenn Verstraete, Michiel De Bruyne, Chris Vervaet, Thomas De Beer It was the aim of this study to elucidate the impact of the injection mold temperature upon the polymer crystallinity, its microstructure and the resulting drug release from immediate and sustained release tablets containing semi-crystalline polymers. The immediate release formulation contained 20% (w/w) ketoprofen (KETO) in poly (ethylene oxide) (PEO) and the sustained release formulation contained...
Source: International Journal of Pharmaceutics - February 24, 2018 Category: Drugs & Pharmacology Source Type: research
Hyponatremia induced by hyperinsulinemia-euglycemia therapy.
CONCLUSION: A woman who overdosed on amlodipine, metoprolol tartrate, and isosorbide mononitrate was treated with HIE therapy and developed symptomatic hyponatremia. Hyponatremia resolved after administration of dextrose with sodium bicarbonate infusion and 3% sodium chloride infusion and cessation of HIE therapy.
PMID: 28687552 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - July 10, 2017 Category: Drugs & Pharmacology Authors: Beavers JR, Stollings JL, Rice TW Tags: Am J Health Syst Pharm Source Type: research
Preparation and evaluation of metoprolol tartrate sustained-release pellets using hot melt extrusion combined with hot melt coating.
The objective of this study was to prepare and evaluate metoprolol tartrate sustained-release pellets. Cores were prepared by hot melt extrusion and coated pellets were prepared by hot melt coating. Cores were found to exist in a single-phase state and drug in amorphous form. Plasticizers had a significant effect on torque and drug content, while release modifiers and coating level significantly affected the drug release behavior. The mechanisms of drug release from cores and coated pellets were Fickian diffusion and diffusion-erosion, respectively. The coated pellets exhibited sustained-release properties in vitro and in ...
Source: Drug Development and Industrial Pharmacy - January 29, 2017 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Efficiency of La-doped TiO2 calcined at different temperatures in photocatalytic degradation of β-blockers
Publication date: Available online 17 January 2017 Source:Arabian Journal of Chemistry Author(s): Sanja J. Armaković, Mirjana Grujić-Brojčin, Maja Šćepanović, Stevan Armaković, Aleksandar Golubović, Biljana Babić, Biljana F. Abramović Photocatalytic activity of titania–based photocatalysts doped with 1% La have been tested in UVA radiation-induced degradation of two β-blockers – metoprolol tartrate (MET) and propranolol hydrochloride (PRO). Photocatalysts have been synthesized by sol–gel process followed by calcination at various temperatures in the range of 450−750 °C. The great impact of calc...
Source: Arabian Journal of Chemistry - January 16, 2017 Category: Chemistry Source Type: research
Older adults with heart failure treated with carvedilol, bisoprolol, or metoprolol tartrate: risk of mortality
ConclusionsOur evidence suggests no differential effect of β‐blockers on all‐cause mortality among older adults with HF. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - November 15, 2016 Category: Drugs & Pharmacology Authors: Sylvie Perreault, Simon Denus, Michel White, Brian White ‐Guay, Michel Bouvier, Marc Dorais, Marie‐Pierre Dubé, Jean‐Lucien Rouleau, Jean‐Claude Tardif, Sarah Jenna, Benjamin Haibe‐Kains, Richard Leduc, Denis Deblois Tags: Original Report Source Type: research
Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation
This study aims to investigate the continuous twin screw melt granulation technique to study the impact of a SA/PEO matrix on the dissolution rate of a highly water soluble drug (MPT). Decreasing the SA/PEO ratio improved the release-sustaining properties of the matrix. The solid state of the granules was characterized using differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared (FTIR) and near infrared chemical imaging (NIR-CI) in order to understand the dissolution behavior. The results revealed a preferential interaction of the M...
Source: International Journal of Pharmaceutics - August 29, 2016 Category: Drugs & Pharmacology Source Type: research
Improving performance of an accountable care organization on a quality measure assessing β-blocker use in systolic heart failure.
CONCLUSION: The performance on a Medicare Pioneer ACO quality measure evaluating β-blocker use in systolic heart failure improved in a one-year period after a clinical pharmacist-generated initiative was implemented at Atrius Health practice sites.
PMID: 27543597 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - August 22, 2016 Category: Drugs & Pharmacology Authors: Elman S, Zaiken K Tags: Am J Health Syst Pharm Source Type: research
Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties.
Abstract
The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing requires fundamental process understanding and the implementation of quality-by-design (QbD) principles. The aim of this study was to examine the relationship between formulation-parameters (type binder, binder concentration, drug-binder miscibility), process-parameters (screw speed, powder feed rate and granulation temperature), granule properties (size...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 19, 2016 Category: Drugs & Pharmacology Authors: Monteyne T, Vancoillie J, Remon JP, Vervaet C, De Beer T Tags: Eur J Pharm Biopharm Source Type: research
Hybrid nanoadsorbents for the magnetically assisted removal of metoprolol from water
Publication date: 15 October 2016 Source:Chemical Engineering Journal, Volume 302 Author(s): Sofia F. Soares, Tânia R. Simões, Maria António, Tito Trindade, Ana L. Daniel-da-Silva Metoprolol (MTP) is known as one of the most frequently detected beta blockers in surface waters, with potentially harmful impact on environment and human health due to its widespread use and resistance to hydrolysis. The removal of MTP in wastewater treatment plants is still very low due to fairly ineffective conventional water treatment procedures and, therefore, more efficient treatments are needed. To tackle this challenge, n...
Source: Chemical Engineering Journal - May 30, 2016 Category: Chemistry Source Type: research
Synchronous delivery of felodipine and metoprolol tartrate using monolithic osmotic pump technology.
Authors: Zhao S, Yu F, Liu N, Di Z, Yan K, Liu Y, Li Y, Zhang H, Yang Y, Yang Z, Li Z, Mei X
Abstract
The synchronous sustained-release of two drugs was desired urgently for patients needing combination therapy in long term. However, sophisticated technologies were used generally to realize the simultaneous delivery of two drugs especially those with different physico-chemical properties. The purpose of this study was to obtain the concurrent release of felodipine and metoprolol tartrate, two drugs with completely different solubilities, in a simple monolithic osmotic pump system (FMOP). Two types of block...
Source: Drug Development and Industrial Pharmacy - April 16, 2016 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
