Melatonin protects against Parkinson's disease via regulating the activation of NLRP3 inflammasome mediated by TLR2
This study aims to explore the effect of MLT on inflammation signaling pathway mediated by TLR2 in α-synuclein (α-syn) overexpressed BV2 cells and PD anima l models, and further elucidates the protective mechanism of MLT in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: X. Wang, J. Li, H. Liu, N. Xiong Source Type: research
Expression of Concern: Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples
Chemosphere. 2024 May;356:142017. doi: 10.1016/j.chemosphere.2024.142017. Epub 2024 Apr 11.NO ABSTRACTPMID:38685657 | DOI:10.1016/j.chemosphere.2024.142017 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575299255240422055203. Online ahead of print.ABSTRACTSkin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflamm...
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Seyedeh Mohaddeseh Mousavi Leila Etemad Davood Yari Maryam Hashemi Zahra Salmasi Source Type: research
Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage
Biol Rev Camb Philos Soc. 2024 Apr 30. doi: 10.1111/brv.13091. Online ahead of print.ABSTRACTMelatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective responses and other functions crucial for survival across different species. The latter properties are also shared by its metabolites including kynuric products generated by reactive oxygen species o...
Source: Biological Reviews of the Cambridge Philosophical Society - April 30, 2024 Category: Biology Authors: Tae-Kang Kim Radomir M Slominski Elzbieta Pyza Konrad Kleszczynski Robert C Tuckey Russel J Reiter Michael F Holick Andrzej T Slominski Source Type: research
Expression of Concern: Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples
Chemosphere. 2024 May;356:142017. doi: 10.1016/j.chemosphere.2024.142017. Epub 2024 Apr 11.NO ABSTRACTPMID:38685657 | DOI:10.1016/j.chemosphere.2024.142017 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Melatonin prevents pulmonary fibrosis caused by PM < sub > 2.5 < /sub > exposure by targeting epithelial-mesenchymal transition
Toxicol Appl Pharmacol. 2024 Apr 28:116949. doi: 10.1016/j.taap.2024.116949. Online ahead of print.ABSTRACTPulmonary fibrosis is a lung disorder characterized by the accumulation of abnormal extracellular matrix, scar tissue formation, and tissue stiffness. Type II alveolar epithelial cells (AEII) play a critical role in repairing lung tissue after injury, and repeated injury to these cells is a key factor in the development of pulmonary fibrosis. Chronic exposure to PM2.5, a type of air pollution, has been shown to increase the incidence and severity of pulmonary fibrosis by enhancing the activation of EMT in lung epithel...
Source: Toxicology and Applied Pharmacology - April 30, 2024 Category: Toxicology Authors: Po-Chun Chen Ming-Hong Yen Sheng-Yen Hsiao Wan-Chen Kao Mei-Ting Wang Pei-Chen Chiou Chia-Chia Chao Source Type: research
Expression of Concern: Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples
Chemosphere. 2024 May;356:142017. doi: 10.1016/j.chemosphere.2024.142017. Epub 2024 Apr 11.NO ABSTRACTPMID:38685657 | DOI:10.1016/j.chemosphere.2024.142017 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575299255240422055203. Online ahead of print.ABSTRACTSkin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflamm...
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Seyedeh Mohaddeseh Mousavi Leila Etemad Davood Yari Maryam Hashemi Zahra Salmasi Source Type: research
Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage
Biol Rev Camb Philos Soc. 2024 Apr 30. doi: 10.1111/brv.13091. Online ahead of print.ABSTRACTMelatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective responses and other functions crucial for survival across different species. The latter properties are also shared by its metabolites including kynuric products generated by reactive oxygen species o...
Source: Biological Reviews of the Cambridge Philosophical Society - April 30, 2024 Category: Biology Authors: Tae-Kang Kim Radomir M Slominski Elzbieta Pyza Konrad Kleszczynski Robert C Tuckey Russel J Reiter Michael F Holick Andrzej T Slominski Source Type: research
Expression of Concern: Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples
Chemosphere. 2024 May;356:142017. doi: 10.1016/j.chemosphere.2024.142017. Epub 2024 Apr 11.NO ABSTRACTPMID:38685657 | DOI:10.1016/j.chemosphere.2024.142017 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy
J Cell Mol Med. 2024 May;28(9):e18338. doi: 10.1111/jcmm.18338.ABSTRACTRespiratory syncytial virus (RSV) infects neuronal cells in the central nervous system (CNS), resulting in neurological symptoms. In the present study, we intended to explore the mechanism of RSV infection-induced neuroinflammatory injury from the perspective of the immune response and sought to identify effective protective measures against the injury. The findings showed that toll-like receptor 4 (TLR4) was activated after RSV infection in human neuronal SY5Y cells. Furthermore, TLR4 activation induced autophagy and apoptosis in neuronal cells, promot...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Yixuan Huang Chengcheng Jiang Xiaojie Liu Wei Tang Hongya Gui Tao Sun Doudou Xu Maozhang He Maozhen Han Huan Qiu Mingwei Chen Shenghai Huang Source Type: research
Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy
J Cell Mol Med. 2024 May;28(9):e18338. doi: 10.1111/jcmm.18338.ABSTRACTRespiratory syncytial virus (RSV) infects neuronal cells in the central nervous system (CNS), resulting in neurological symptoms. In the present study, we intended to explore the mechanism of RSV infection-induced neuroinflammatory injury from the perspective of the immune response and sought to identify effective protective measures against the injury. The findings showed that toll-like receptor 4 (TLR4) was activated after RSV infection in human neuronal SY5Y cells. Furthermore, TLR4 activation induced autophagy and apoptosis in neuronal cells, promot...
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Yixuan Huang Chengcheng Jiang Xiaojie Liu Wei Tang Hongya Gui Tao Sun Doudou Xu Maozhang He Maozhen Han Huan Qiu Mingwei Chen Shenghai Huang Source Type: research
Assessing the Feasibility and Efficacy of Pre-Sleep Dim Light Therapy for Adults with Insomnia: A Pilot Study
Conclusions: This study provides evidence for the efficacy of LT in improving sleep quality and circadian rhythm alignment in adults with insomnia. Despite limitations, such as a small sample size and short study duration, the results underscore the potential of LT as a viable non-pharmacological approach for insomnia. Future research should expand on these results with larger and more diverse cohorts followed over a longer period to validate and further elucidate the value of LT in sleep medicine. Trial registration: The trial was registered with the Clinical Research Information Service (KCT0008501).PMID:38674278 | PMC:P...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jihyun Yoon Seok-Jae Heo Hyangkyu Lee Eun-Gyeong Sul Taehwa Han Yu-Jin Kwon Source Type: research
Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis
CONCLUSIONS: These findings suggested that melatonin inhibited IAV infection, improved lung function and lung damages of AECOPD via suppressing IL-1β/STAT1-driven macrophage M1 polarization and apoptosis in a MTs-dependent manner. Melatonin may be considered as a potential therapeutic agent for influenza virus infection-induced AECOPD.PMID:38678295 | DOI:10.1186/s12931-024-02815-0 (Source: Respiratory Care)
Source: Respiratory Care - April 27, 2024 Category: Respiratory Medicine Authors: Meng-Meng Xu Jia-Ying Kang Qiu-Yan Wang Xing Zuo Yuan-Yuan Tan Yuan-Yuan Wei Da-Wei Zhang Ling Zhang Hui-Mei Wu Guang-He Fei Source Type: research
Assessing the Feasibility and Efficacy of Pre-Sleep Dim Light Therapy for Adults with Insomnia: A Pilot Study
Conclusions: This study provides evidence for the efficacy of LT in improving sleep quality and circadian rhythm alignment in adults with insomnia. Despite limitations, such as a small sample size and short study duration, the results underscore the potential of LT as a viable non-pharmacological approach for insomnia. Future research should expand on these results with larger and more diverse cohorts followed over a longer period to validate and further elucidate the value of LT in sleep medicine. Trial registration: The trial was registered with the Clinical Research Information Service (KCT0008501).PMID:38674278 | PMC:P...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jihyun Yoon Seok-Jae Heo Hyangkyu Lee Eun-Gyeong Sul Taehwa Han Yu-Jin Kwon Source Type: research
