Is the Time Ripe to Shift to Oral Vitamin B12 Therapy in Megaloblastic Anemia - Perhaps, Not Yet!
Indian Pediatr. 2022 Sep 15;59(9):679-680.NO ABSTRACTPMID:36101947 (Source: Indian Pediatrics)
Source: Indian Pediatrics - September 14, 2022 Category: Pediatrics Authors: Mukul Aggarwal Amiya Ranjan Nayak Manoranjan Mahapatra Source Type: research
Vitamin B12 supplementation post-gastrectomy: a service closed-loop audit at St. James ’s Hospital, Dublin
ConclusionThis study demonstrates good adherence in those undergoing TG. Patient understanding correlates with adherence, suggesting that patient education and knowledge reinforcement may be key to adherence with VB12 supplementation. A simple educational intervention can improve adherence with VB12 supplementation in patients undergoing gastrectomy. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - August 15, 2022 Category: General Medicine Source Type: research
Case report: Novel compound-heterozygous mutations in the TCN2 gene identified in a chinese girl with transcobalamin deficiency
This study contributes to a better understanding of the TC deficiency, expanding the spectrum of TCN2 mutations in this disorder and also supporting the early diagnosis and proper treatment of similar cases in the future. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - August 12, 2022 Category: Genetics & Stem Cells Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Biogenic silver nanoparticles (AgNp-Bio) restore testosterone levels and increase TNF- α and IL-6 in Leydig cells infected with Toxoplasma gondii
This study aimed to evaluate the in vitro effects of biogenic silver nanoparticles (AgNp-Bio) on tachyzoite forms and Leydig cells infected with T. gondii. We observed that the AgNp-Bio reduced the viability of the tachyzoites and did not exhibit cytotoxicity against Leydig cells at low concentrations. Additionally, treatment with AgNp-Bio reduced the rate of infection and proliferation of the parasite, and lowered the testosterone levels in the infected cells. It increased the levels of IL-6 and TNF-α and reduced the levels of IL- 10. Among the morphological and ultrastructural changes, AgNp-Bio induced a reduction in th...
Source: Experimental Parasitology - August 9, 2022 Category: Parasitology Authors: Sara Sofia Lopes Semedo Raquel Arruda da Silva Sanfelice Fernanda Tomiotto-Pellissier Taylon Felipe Silva Bruna Taciane da Silva Bortoleti Gabriela Correia de Oliveira Gl áucia Eloisa Munhoz de Lion Siervo Larissa Rodrigues Bosqui Danielle Lazarin-Bid ó Source Type: research
Retinopathy of Megaloblastic Anemia: Treatable and Reversible
A 14-year-old girl presented with yellowish skin for 20 days; dizziness and fatigability for 10 days; limb tingling and numbness for 7 days; fever, chills, and vomiting for 5 days; and intermittent, painless blurry vision bilaterally for 4 days. There were no other symptoms, and there was no history of blood transfusion of dyscrasia. She consumed a vegetarian diet. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 6, 2022 Category: Pediatrics Authors: Lekshmi Sambhu Hema, Pradeep Kumar Gunasekaran, Manjari Tandon, Siyaram Didel, Lokesh Saini, Kuldeep Singh Tags: Rediscovering the Physical Exam Source Type: research
Retinopathy of Megaloblastic Anaemia: Treatable and reversible.
A 14-year-old girl presented with yellowish skin for 20 days, dizziness and fatigability for 10 days, limb tingling and numbness for 7 days, fever, chills, and vomiting for 5 days, and intermittent, painless blurry vision bilaterally for 4 days. There were no other symptoms and there was no history of blood transfusion of dyscrasia. . She was a vegetarian by diet. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 6, 2022 Category: Pediatrics Authors: Lekshmi Sambhu Hema, Pradeep Kumar Gunasekaran, Manjari Tandon, Siyaram Didel, Lokesh Saini, Kuldeep Singh Tags: Rediscovering the Physical Exam Source Type: research
Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision
AbstractPurposeof ReviewThis review aims to provide an update on the etiologies of diabetes that are due to genetic disorders and that co-occur with impaired hearing or vision and to compare them. The potential mechanisms, including novel treatments, will be detailed.Recent FindingsWolfram syndrome, Kearns –Sayre syndrome, thiamine-responsive megaloblastic anemia, and maternally inherited diabetes and deafness are genetic disorders characterized by diabetes, impaired hearing, and vision. They differ in mode of inheritance, age at presentation, and the involvement of other organs; they are often misd iagnosed as type 1 or...
Source: Current Diabetes Reports - July 5, 2022 Category: Endocrinology Source Type: research
An infantile case of hereditary folate malabsorption with sudden development of pulmonary hemorrhage: a case report
ConclusionWe report an infantile case of hereditary folate malabsorption that progressed to lethal pulmonary hemorrhage before folate deficiency was identified. Clinicians should consider that megaloblastic anemia could lead to severe bleeding without warning, and that nutrient supplementation should be initiated as soon as possible. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 30, 2022 Category: General Medicine Source Type: research
