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The boon and bane of nitrous oxide
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 13. doi: 10.1007/s00406-024-01801-3. Online ahead of print.ABSTRACTNitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be small. The recreational and medical uses of N2O gradually diverged over time. N2O has analgesic and anesthetic effects, makin...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2024 Category: Psychiatry Authors: Golo Kronenberg Georgios Schoretsanitis Erich Seifritz Sebastian Olbrich Source Type: research

The boon and bane of nitrous oxide
AbstractNitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be small. The recreational and medical uses of N2O gradually diverged over time. N2O has analgesic and anesthetic effects, making it widely used in modern dentistry and surgery. New research has also begun studying N2O ’s antidep...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2024 Category: Neuroscience Source Type: research

Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet
We report the case of an 11-year-old boy with ASD who developed megaloblastic anemia due to vitamin B12 deficiency. He had a prolonged history of selective eating for more than 10 years. His nutritional status on admission was poor, and he had low weight and short stature. His food selectivity was so strong that intervention to expand diet variety was unsuccessful. A developmental-behavioral pediatrician found that the patient had visual dominance and could take some medications when suffering from a minor illness. Nutritional supplements were selected after consultation with a nutritionist. Although compulsory treatment w...
Source: International Journal of Hematology - March 25, 2024 Category: Hematology Authors: Yuri Sawada Kenichi Sakamoto Atsushi Tsukamura Chihiro Sawai Source Type: research

Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
ConclusionThese results demonstrate that aboveCUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum ofCUBN and benefiting our understanding of proteinuria and renal function. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - March 15, 2024 Category: Genetics & Stem Cells Authors: Huihui Yang, Lanfen He, Hongjian Gong, Chunhui Wan, Juanjuan Ding, Panli Liao, Xiaowen Wang Tags: ORIGINAL ARTICLE Source Type: research

Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
CONCLUSION: These results demonstrate that above CUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum of CUBN and benefiting our understanding of proteinuria and renal function.PMID:38488435 | DOI:10.1002/mgg3.2353 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Huihui Yang Lanfen He Hongjian Gong Chunhui Wan Juanjuan Ding Panli Liao Xiaowen Wang Source Type: research

Identification of novel pathogenic variants of CUBN in patients with isolated proteinuria
CONCLUSION: These results demonstrate that above CUBN mutations may cause non-progressive and isolated proteinuria, expanding the variant spectrum of CUBN and benefiting our understanding of proteinuria and renal function.PMID:38488435 | PMC:PMC10941600 | DOI:10.1002/mgg3.2353 (Source: Molecular Medicine)
Source: Molecular Medicine - March 15, 2024 Category: Molecular Biology Authors: Huihui Yang Lanfen He Hongjian Gong Chunhui Wan Juanjuan Ding Panli Liao Xiaowen Wang Source Type: research

Severe megaloblastic anemia in a patient with advanced lung adenocarcinoma during treatment with erlotinib: a case report and literature review
Erlotinib is a first-generation, tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR-TKI) used for the treatment patients with NSCLC. Erlotinib is considered as a safe and effective treatme... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - March 6, 2024 Category: Respiratory Medicine Authors: Xin Yan, Jingxian Kong, Jiacheng Wang, Caixia Wang and Hongchang Shen Tags: Case Report Source Type: research

Knuckle hyperpigmentation in a young male: A clinical sign of B12 deficiency not to be missed
Trop Doct. 2024 Feb 29:494755241234081. doi: 10.1177/00494755241234081. Online ahead of print.ABSTRACTVitamin B12 and folate deficiency are reversible causes of megaloblastic anemia. Strict vegetarians are at risk of megaloblastic anemia due to low cobalamin in their diet. Knuckle hyperpigmentation in patients with megaloblastic anemia is due to excess melanin synthesis in skin. Here we present a case of a young vegetarian male with megaloblastic anemia with knuckle hyperpigmentation managed successfully with intravenous followed by oral vitamin b12 and folate supplementation.PMID:38419508 | DOI:10.1177/00494755241234081 (...
Source: Tropical Doctor - February 29, 2024 Category: Tropical Medicine Authors: Harpreet Singh Arvind Subramanian Deba P Dibhar Vikas Suri Ashish Bhalla Source Type: research