Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial
CONCLUSION: Increase in serum vitamin B12 levels and hemoglobin was better in children with nutritional macrocytic anemia receiving parenteral as compared to oral vitamin B12.PMID:35642923 (Source: Indian Pediatrics)
Source: Indian Pediatrics - June 1, 2022 Category: Pediatrics Authors: Rahul Tandon Jigar Thacker Utkarsh Pandya Mamta Patel Krutika Tandon Source Type: research
Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial
CONCLUSION: Increase in serum vitamin B12 levels and hemoglobin was better in children with nutritional macrocytic anemia receiving parenteral as compared to oral vitamin B12.PMID:35642923 (Source: Indian Pediatrics)
Source: Indian Pediatrics - June 1, 2022 Category: Pediatrics Authors: Rahul Tandon Jigar Thacker Utkarsh Pandya Mamta Patel Krutika Tandon Source Type: research
Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial
CONCLUSION: Increase in serum vitamin B12 levels and hemoglobin was better in children with nutritional macrocytic anemia receiving parenteral as compared to oral vitamin B12.PMID:35642923 (Source: Indian Pediatrics)
Source: Indian Pediatrics - June 1, 2022 Category: Pediatrics Authors: Rahul Tandon Jigar Thacker Utkarsh Pandya Mamta Patel Krutika Tandon Source Type: research
Transporters in drug development: International transporter consortium update on emerging transporters of clinical importance
Clin Pharmacol Ther. 2022 May 13. doi: 10.1002/cpt.2644. Online ahead of print.ABSTRACTDuring its 4th transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up-to-date clinical evidence of their importance in drug-drug interactions and potential for altered drug efficacy and safety, including drug-nutrient interactions leading to nutrient deficiencies. For the first time, folate transport pathways (PCFT, RFC, and FRα) were examined in-depth as a pote...
Source: Clinical Pharmacology and Therapeutics - May 13, 2022 Category: Drugs & Pharmacology Authors: Maciej J Zamek-Gliszczynski Vishal Sangha Hong Shen Bo Feng Matthias B Wittwer Manthena V S Varma Xiaomin Liang Yuichi Sugiyama Lei Zhang Reina Bendayan International Transporter Consortium Source Type: research
Transporters in drug development: International transporter consortium update on emerging transporters of clinical importance
Clin Pharmacol Ther. 2022 May 13. doi: 10.1002/cpt.2644. Online ahead of print.ABSTRACTDuring its 4th transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up-to-date clinical evidence of their importance in drug-drug interactions and potential for altered drug efficacy and safety, including drug-nutrient interactions leading to nutrient deficiencies. For the first time, folate transport pathways (PCFT, RFC, and FRα) were examined in-depth as a pote...
Source: Clinical Pharmacology and Therapeutics - May 13, 2022 Category: Drugs & Pharmacology Authors: Maciej J Zamek-Gliszczynski Vishal Sangha Hong Shen Bo Feng Matthias B Wittwer Manthena V S Varma Xiaomin Liang Yuichi Sugiyama Lei Zhang Reina Bendayan International Transporter Consortium Source Type: research
A novel TCN2 mutation with unusual clinical manifestations of hemolytic crisis and unexplained metabolic acidosis: expanding the genotype and phenotype of transcobalamin II deficiency
Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation. (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 29, 2022 Category: Pediatrics Authors: Pongpak Pongphitcha, Nongnuch Sirachainan, Arthaporn Khongkraparn, Thipwimol Tim-Aroon, Duantida Songdej and Duangrurdee Wattanasirichaigoon Tags: Case report Source Type: research
Absolute Neutrophil Count in Cases of Pancytopenia
Conclusion: On univariate and multivariate analysis ANC was significantly lower at baseline in patients of aplastic anemia. A longer follow-up of the patients will be required to assess the value of ANC in predicting response to therapy.PMID:35443536 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - April 21, 2022 Category: General Medicine Authors: Mathews N Mathew Kundan Mishra Kanwaljeet Singh Suman Kumar Parmanik Source Type: research
