Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait
CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research
Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait
CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research
Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait
CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research
Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait
CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research
Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait
CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research
Effect of megaloblastic anemia on hemoglobin A < sub > 2 < /sub > and diagnosis of β-thalassemia trait
CONCLUSIONS: Megaloblastic anemia can lead to false-positive diagnosis of β-thalassemia trait on HPLC. Repeat HPLC should be done after adequate supplementation of vitamin B12 and folic acid in cases of megaloblastic anemia with raised HbA2. Red cell parameters are not helpful to suspect β-thalassemia trait in presence of megaloblastic anemia. However, HbA2% on HPLC can be a useful parameter to suspect or exclude β-thalassemia trait in cases of megaloblastic anemia.PMID:37077076 | DOI:10.4103/ijpm.ijpm_233_21 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 20, 2023 Category: Pathology Authors: Sulagna Sahoo Nageswar Sahu Palash Das Urmila Senapati Source Type: research
Hereditary orotic aciduria identified by newborn screening
Conclusion: Newborn screening measuring of orotic acid, now integrated into the routine tandem mass spectrometry panel, is capable of identifying neonates with hereditary orotic aciduria. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - March 14, 2023 Category: Genetics & Stem Cells Source Type: research
Comparison of Serum Holotranscobalamin with Serum Vitamin B12 in Population Prone to Megaloblastic Anemia and their Correlation with Nerve Conduction Study
This study was conducted to compare serum holotranscobalamin level with serum vitamin B12 level as early biomarker in people prone to megaloblastic anemia and to evaluate co-relation between these biomarkers and nerve conduction study in study patients. 83 adult patients (Hb > 12 gm/dl) prone to megaloblastic anemia were studied for basic haematological investigations, random blood sugar, thyroid function test, liver function test, kidney function test, serum vitamin B12, serum holotranscobalamin and serum folic acid levels. 45 patients among them underwent nerve conduction studies. All study patients were classified in...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: Abhishek Verma Sunita Aggarwal Sandeep Garg Smita Kaushik Debashish Chowdhury Source Type: research
Comparison of Serum Holotranscobalamin with Serum Vitamin B12 in Population Prone to Megaloblastic Anemia and their Correlation with Nerve Conduction Study
This study was conducted to compare serum holotranscobalamin level with serum vitamin B12 level as early biomarker in people prone to megaloblastic anemia and to evaluate co-relation between these biomarkers and nerve conduction study in study patients. 83 adult patients (Hb > 12 gm/dl) prone to megaloblastic anemia were studied for basic haematological investigations, random blood sugar, thyroid function test, liver function test, kidney function test, serum vitamin B12, serum holotranscobalamin and serum folic acid levels. 45 patients among them underwent nerve conduction studies. All study patients were classified in...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: Abhishek Verma Sunita Aggarwal Sandeep Garg Smita Kaushik Debashish Chowdhury Source Type: research
Comparison of Serum Holotranscobalamin with Serum Vitamin B12 in Population Prone to Megaloblastic Anemia and their Correlation with Nerve Conduction Study
This study was conducted to compare serum holotranscobalamin level with serum vitamin B12 level as early biomarker in people prone to megaloblastic anemia and to evaluate co-relation between these biomarkers and nerve conduction study in study patients. 83 adult patients (Hb > 12 gm/dl) prone to megaloblastic anemia were studied for basic haematological investigations, random blood sugar, thyroid function test, liver function test, kidney function test, serum vitamin B12, serum holotranscobalamin and serum folic acid levels. 45 patients among them underwent nerve conduction studies. All study patients were classified in...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: Abhishek Verma Sunita Aggarwal Sandeep Garg Smita Kaushik Debashish Chowdhury Source Type: research
Comparison of Serum Holotranscobalamin with Serum Vitamin B12 in Population Prone to Megaloblastic Anemia and their Correlation with Nerve Conduction Study
This study was conducted to compare serum holotranscobalamin level with serum vitamin B12 level as early biomarker in people prone to megaloblastic anemia and to evaluate co-relation between these biomarkers and nerve conduction study in study patients. 83 adult patients (Hb > 12 gm/dl) prone to megaloblastic anemia were studied for basic haematological investigations, random blood sugar, thyroid function test, liver function test, kidney function test, serum vitamin B12, serum holotranscobalamin and serum folic acid levels. 45 patients among them underwent nerve conduction studies. All study patients were classified in...
Source: Clinical Biochemistry - January 23, 2023 Category: Biochemistry Authors: Abhishek Verma Sunita Aggarwal Sandeep Garg Smita Kaushik Debashish Chowdhury Source Type: research
Black Cohosh Herbal Extract and Hematologic Alterations in B6C3F1/N Mice
This article will review basic mechanisms and laboratory features of megaloblastic anemia. The results of our studies including morphological abnormalities of the erythron and biomarkers of folate and cobalamin deficiencies, as well as hepatic microarray gene changes, are also discussed.PMID:36373576 | DOI:10.1177/01926233221133549 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - November 14, 2022 Category: Pathology Authors: Michelle Cora Source Type: research
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas
Cochrane Database Syst Rev. 2022 Feb 1;2(2022). doi: 10.1002/14651858.CD014217.ABSTRACTBACKGROUND: Description of the condition Malaria, an infectious disease transmitted by the bite of female mosquitoes from several Anopheles species, occurs in 87 countries with ongoing transmission (WHO 2020). The World Health Organization (WHO) estimated that, in 2019, approximately 229 million cases of malaria occurred worldwide, with 94% occurring in the WHO's African region (WHO 2020). Of these malaria cases, an estimated 409,000 deaths occurred globally, with 67% occurring in children under five years of age (WHO 2020). Malaria also...
Source: Cochrane Database of Systematic Reviews - November 2, 2022 Category: General Medicine Authors: Krista Crider Jennifer Williams Yan Ping Qi Julie Gutman Lorraine Yeung Cara Mai Julia Finkelstain Saurabh Mehta Clara Pons-Duran Clara Men éndez Cinta Moraleda Lisa Rogers Kelicia Daniels Patricia Green Source Type: research
Primary Neurologic Symptoms: Have you Considered Pernicious Anemia?
Background: Vitamin B12, or cobalamin, is a nutrient that is vital for metabolic function. Absorption of ingested B12 is dependent on intrinsic factor, which is secreted by parietal cells within the stomach. Pernicious anemia is caused by an intrinsic factor deficiency or autoantibodies against intrinsic factor. The presence of parietal cell antibodies can destroy parietal cells, which can also lead to a deficiency in intrinsic factor. Both lead to megaloblastic anemia caused by vitamin B12 deficiency. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - October 28, 2022 Category: Emergency Medicine Authors: Andrew D. Yocum, Mili Patel, Bradley Palocko, Erin L. Simon Source Type: research
Serum folate levels in children with epilepsy seen in a tertiary health care facility in north central Nigeria
Conclusion: The mean serum folate level in subjects was significantly lower than the value in controls; but was comparable in subjects on carbamazepine, phenobarbitone, and valproate as monotherapy. There was no correlation between the duration of AED use and mean serum folate levels (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - October 26, 2022 Category: Rural Health Authors: PN Omefe MA N Adeboye SA Biliaminu Ayodele Ojuawo Source Type: research
