Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Vitamin B12 deficiency
Vitam Horm. 2022;119:405-439. doi: 10.1016/bs.vh.2022.02.003. Epub 2022 Mar 11.ABSTRACTOf the water-soluble vitamins, vitamin B12 (B12) has the lowest daily requirement. It also has several unique properties including a complex pathway for its absorption and assimilation requiring intact gastric and terminal small intestinal function, an enterohepatic pathway, and several dedicated binding proteins and chaperons. The many causes of B12 deficiency include malabsorption and defects in cellular delivery and uptake, as well as limited dietary intake. B12 is required as a cofactor for only two reactions in humans, the cytosolic...
Source: Vitamins and Hormones - March 26, 2022 Category: Endocrinology Authors: Ralph Green Joshua W Miller Source Type: research
Comparison of Serum Holotranscobalamin with Serum Vitamin B12 in Population Prone to Megaloblastic Anemia and their Correlation with Nerve Conduction Study
This study was conducted to compare serum holotranscobalamin level with serum vitamin B12 level as early biomarker in people prone to megaloblastic anemia and to evaluate co-relation between these biomarkers and nerve conduction study in study patients. 83 adult patients (Hb > 12 gm/dl) prone to megaloblastic anemia were studied for basic haematological investigations, random blood sugar, thyroid function test, liver function test, kidney function test, serum vitamin B12, serum holotranscobalamin and serum folic acid levels. 45 patients among them underwent nerve condu ction studies. All study patients were classi...
Source: Indian Journal of Clinical Biochemistry - March 17, 2022 Category: Biochemistry Source Type: research
Paget's disease of bone and megaloblastic anemia in a 72-year-old patient: A case report and systematic literature review
Exp Ther Med. 2022 Apr;23(4):269. doi: 10.3892/etm.2022.11195. Epub 2022 Feb 8.ABSTRACTPaget's disease of bone (PDB) is characterized by abnormal osteoclastic bone resorption with disorganized bone neo-formation, primarily affecting elderly (>55 years) patients. Although the majority of patients are asymptomatic, some patients may experience bone pain due to local periosteal involvement or osteoarthritic lesions in the spine; in addition, limb deformities may lead to secondary gait problems or degenerative joint changes. Anemia has an overall prevalence of 12-17% in elderly adults (>65 years old), with macrocytic ane...
Source: Experimental and Therapeutic Medicine - March 7, 2022 Category: General Medicine Authors: Violeta Diana Oprea Violeta Claudia Bojinc ă Andra-Rodica B ălănescu Alin Lauren țiu Tatu Mihai Bojinc ă Aurelia Romila Source Type: research
