Delineating molecular regulatory network of meat quality of longissimus dorsi indicated by transcriptomic, proteomic, and metabolomics analysis in rabbit
This study aims to investigate the potential regulatory network responsible for the meat quality using multi-omics to help developing better varieties. Slaughter performance and meat quality of Shuxing No.1 rabbit outperformed IRA rabbit according to the tested rabbit parameters. Differentially expressed genes (DEGs) and differentially abundance proteins (DAPs) were involved in meat quality-related pathways, such as PI3K - Akt and MAPK signaling pathway. Only SMTNL1 and PM20D2 shared between DEGs and DAPs. Olfactory-sensitive undecanal, a differentially abundant metabolite (DAM) in volatilomics (vDAMs), correlated with all...
Source: Journal of Proteomics - April 24, 2024 Category: Biochemistry Authors: Liangde Kuang Jianhong Zeng Yuying Li Jie Zheng Yongjun Ren Zhiqiang Guo Xiangyu Zhang Cuixia Zhang Chao Yang Xiuli Mei Rui Yang Li Tang Yang Ji Xiaohong Xie Min Lei Congyan Li Source Type: research
Food and Drug Omnibus Reform Act: A Critical Course Correction
On December 29, 2022, the Consolidated Appropriations Act, 2023 (Public Law No. 117-328) was signed into law, containing the Food and Drug Omnibus Reform Act of 2022 (FDORA), which introduces significant reforms to the US Food and Drug Administration (FDA).1 This paper highlights select provisions of FDORA that, in our view, have broad implications for the clinical and pharmaceutical sectors, such as promoting clinical trial diversity, revising the accelerated approval process, modernizing clinical trial operations, updating marketing exclusivities, expanding cosmetics regulation, and fortifying infant formula oversight. (...
Source: Mayo Clinic Proceedings - April 24, 2024 Category: Internal Medicine Authors: Aditya Narayan, I. Glenn Cohen, Eli Y. Adashi Tags: Perspectives and controversies Source Type: research
[[Translated article]]Allergic Contact Dermatitis to Topical Ophthalmic Drugs: Review of Frequently Used Allergens in Spain
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00356-9. doi: 10.1016/j.ad.2024.04.015. Online ahead of print.ABSTRACTAllergic contact dermatitis induced by the use of ophthalmic topical drugs is one of the most common causes of eyelid dermatitis. The introduction of new formulations, both of active ingredients and excipients, and the lack of marketing in some of them, makes patch testing in patients whose source of contact are topical ophthalmic drugs truly challenging. Across this manuscript, most, if not all, topical ophthalmic drugs used in our national health system have been collected, including information on the al...
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: M D Pegalajar-Garc ía B A Coronel-Gonz ález F J Navarro-Trivi ño Source Type: research
[[Translated article]]Allergic Contact Dermatitis to Topical Ophthalmic Drugs: Review of Frequently Used Allergens in Spain
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00356-9. doi: 10.1016/j.ad.2024.04.015. Online ahead of print.ABSTRACTAllergic contact dermatitis induced by the use of ophthalmic topical drugs is one of the most common causes of eyelid dermatitis. The introduction of new formulations, both of active ingredients and excipients, and the lack of marketing in some of them, makes patch testing in patients whose source of contact are topical ophthalmic drugs truly challenging. Across this manuscript, most, if not all, topical ophthalmic drugs used in our national health system have been collected, including information on the al...
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: M D Pegalajar-Garc ía B A Coronel-Gonz ález F J Navarro-Trivi ño Source Type: research
Healthcare processes for parent participation in neonatal intensive care units: A self-determination theory perspective
. (Source: Health Marketing Quarterly)
Source: Health Marketing Quarterly - April 22, 2024 Category: International Medicine & Public Health Authors: Steven W. RayburnSidney AndersonYamile C. Jacksona Marketing, Texas State University, San Marcos, TX, USAb CEO, Nurtured by Design, Sugar Land, TX, USA Source Type: research
Themes in e-liquid concept names as a marketing tactic: evidence from Premarket Tobacco Product Applications in the USA
Concept naming of flavours is popular among e-liquid manufacturers.1–3 Rather than explicitly stating a taste or smell, these names convey aesthetics or sensations (eg, unicorn, frostbite, roadhouse), as well as positive health and lifestyle experiences (eg, relaxed, blissful).4 Concept names are frequently accompanied by colourful packaging and bottle designs that reinforce their connotations.1 2 While concept naming is not novel, its impact on youth appeal, as distinct from the flavours themselves, is understudied.5 Concept naming warrants additional attention following US regulatory developments limiting character...
Source: Tobacco Control - April 19, 2024 Category: Respiratory Medicine Authors: Laestadius, L., Vassey, J., Kim, M., Ozga, J., Li, D., Stanton, C., Wipfli, H., Unger, J. B. Tags: Open access Industry watch Source Type: research
'Tobacco-free claims in tobacco product marketing in the United States
Tobacco control research, policy and advocacy are replete with ‘tobacco-free’ terminology. For instance, there are tobacco-free initiatives targeting removal of tobacco use, imagery and branding from major entertainment media.1 2 There are also policies promoting tobacco-free college campuses,3 parks,4 pharmacies5 and workplaces6 which help protect the environment from tobacco product litter, reduce exposure to secondhand smoke and denormalise tobacco use. The goals of these and other efforts are to create a tobacco-free generation7 and even a tobacco-free world.8 In recent years, tobacco manufacturers have beg...
Source: Tobacco Control - April 19, 2024 Category: Respiratory Medicine Authors: Seidenberg, A., Kaufman, A. Tags: Special communication Source Type: research
Promoting new users ’ online health consultation services usage behavior strategically
. (Source: Health Marketing Quarterly)
Source: Health Marketing Quarterly - April 18, 2024 Category: International Medicine & Public Health Authors: Annie ChenWei-Min ChuNorman Penga Roehampton Business School, Roehampton University, London, United Kingdomb Division Chief of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwanc National Yang Ming Chiao Tung University, Hsinchu, Taiwan Source Type: research
Decolonizing Impact Through the Culture-Centered Approach to Health Communication: Mobilizing Communities to Transform the Structural Determinants of Health
. (Source: Health Communication)
Source: Health Communication - April 18, 2024 Category: Health Management Authors: Mohan J. DuttaSatveer Kaur-GillSelina Metuamatea Center for Culture-Centered Approach to Research and Evaluation (CARE), School of Communication, Journalism and Marketing, Massey Universityb Department of Communication Studies, University of Nebraska-Linc Source Type: research
Current uncertainties and challenges of publicly available pharmaceutical environmental risk assessment data
Eur J Pharm Sci. 2024 Apr 16;197:106769. doi: 10.1016/j.ejps.2024.106769. Online ahead of print.ABSTRACTPharmaceutical residues are widely detected in aquatic environment worldwide mainly arising from human excretions in sewage systems. Presently, publicly available, high quality environmental risk assessment (ERA) data for pharmaceuticals are limited. However, databases like the Swedish Fass offer valuable resources aiding healthcare professionals and environmental scientists in identifying substances of significant concern. In this review, we provide a concise overview of the regulatory ERA process for medicinal products...
Source: European Journal of Pharmaceutical Sciences - April 17, 2024 Category: Drugs & Pharmacology Authors: H Ahkola L Äystö T Sikanen S Riikonen T Pihlaja S Kauppi Source Type: research
Unhealthy Food and Beverage Marketing to Children in the Digital Age: Global Research and Policy Challenges and Priorities
Annu Rev Nutr. 2024 Apr 17. doi: 10.1146/annurev-nutr-062322-014102. Online ahead of print.ABSTRACTFood and nonalcoholic beverage marketing is implicated in poor diet and obesity in children. The rapid growth and proliferation of digital marketing has resulted in dramatic changes to advertising practices and children's exposure. The constantly evolving and data-driven nature of digital food marketing presents substantial challenges for researchers seeking to quantify the impact on children and for policymakers tasked with designing and implementing restrictive policies. We outline the latest evidence on children's experien...
Source: Annual Review of Nutrition - April 17, 2024 Category: Nutrition Authors: Emma Boyland Kathryn Backholer Monique Potvin Kent Marie A Bragg Fiona Sing Tilakavati Karupaiah Bridget Kelly Source Type: research
Current uncertainties and challenges of publicly available pharmaceutical environmental risk assessment data
Eur J Pharm Sci. 2024 Apr 15:106769. doi: 10.1016/j.ejps.2024.106769. Online ahead of print.ABSTRACTPharmaceutical residues are widely detected in aquatic environment worldwide mainly arising from human excretions in sewage systems. Presently, publicly available, high quality environmental risk assessment (ERA) data for pharmaceuticals are limited. However, databases like the Swedish Fass offer valuable resources aiding healthcare professionals and environmental scientists in identifying substances of significant concern. In this review, we provide a concise overview of the regulatory ERA process for medicinal products int...
Source: European Journal of Pharmaceutical Sciences - April 17, 2024 Category: Drugs & Pharmacology Authors: H Ahkola L Äystö T Sikanen S Riikonen T Pihlaja S Kauppi Source Type: research
Unhealthy Food and Beverage Marketing to Children in the Digital Age: Global Research and Policy Challenges and Priorities
Annu Rev Nutr. 2024 Apr 17. doi: 10.1146/annurev-nutr-062322-014102. Online ahead of print.ABSTRACTFood and nonalcoholic beverage marketing is implicated in poor diet and obesity in children. The rapid growth and proliferation of digital marketing has resulted in dramatic changes to advertising practices and children's exposure. The constantly evolving and data-driven nature of digital food marketing presents substantial challenges for researchers seeking to quantify the impact on children and for policymakers tasked with designing and implementing restrictive policies. We outline the latest evidence on children's experien...
Source: Annual Review of Nutrition - April 17, 2024 Category: Nutrition Authors: Emma Boyland Kathryn Backholer Monique Potvin Kent Marie A Bragg Fiona Sing Tilakavati Karupaiah Bridget Kelly Source Type: research
Increased risk of hypocalcemia with decreased kidney function in patients prescribed bisphosphonates based on real-world data from the MID-NET ® in Japan: a new-user cohort study
In the post-marketing stage, cases of hypocalcemia associated with bisphosphonate preparations (BPs) have been reported in patients with decreased kidney function, despite warning against use of BPs in such pa... (Source: BMC Nephrology)
Source: BMC Nephrology - April 15, 2024 Category: Urology & Nephrology Authors: Tomoaki Hasegawa, Maki Komamine, Chieko Ishiguro, Haruka Motomura, Kazuhiro Kajiyama, Takahiro Nonaka, Yuki Nakazato, Ryota Kimura, Harumi Maniwa, Toyotaka Iguchi, Naoya Horiuchi and Yoshiaki Uyama Tags: Research Source Type: research
Adjusting starting points for initial price offers: the example of ibrutinib
This article focuses on the data obtained for ibrutinib, an oral medication for treating hematologic malignancies, which is one of the only drugs reviewed by the committee that also has been selected for Medicare price negotiation. We examine data that can be obtained only from the drug manufacturer that the IRA has explicitly identified as being used to determine the price and suggest potential negotiation strategies for CMS in response.PMID:38603534 | DOI:10.37765/ajmc.2024.89531 (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - April 11, 2024 Category: Health Management Authors: Jason B Gibbons Charles L Bennett Kenneth R Carson Gerard F Anderson Source Type: research
