Profiling lecanemab as a treatment option for Alzheimer's disease
Expert Rev Neurother. 2024 Apr 3:1-9. doi: 10.1080/14737175.2024.2333970. Online ahead of print.ABSTRACTINTRODUCTION: In July 2023, the U.S. Food and Drug Administration (FDA) granted full approval to lecanemab for the treatment of mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and mild AD dementia. Considering the limited treatment options for AD, the approval of lecanemab offers hope and opens the door for other disease-modifying therapies in the pipeline.AREAS COVERED: In this review, the authors summarize the FDA treatment guidelines, other anti-amyloid agents, and drug information relevant to prescrib...
Source: Expert Review of Neurotherapeutics - April 3, 2024 Category: Neurology Authors: Emily R Schiller Bret David Silverglate George T Grossberg Source Type: research
Profiling lecanemab as a treatment option for Alzheimer's disease
Expert Rev Neurother. 2024 May;24(5):433-441. doi: 10.1080/14737175.2024.2333970. Epub 2024 Apr 3.ABSTRACTINTRODUCTION: In July 2023, the U.S. Food and Drug Administration (FDA) granted full approval to lecanemab for the treatment of mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and mild AD dementia. Considering the limited treatment options for AD, the approval of lecanemab offers hope and opens the door for other disease-modifying therapies in the pipeline.AREAS COVERED: In this review, the authors summarize the FDA treatment guidelines, other anti-amyloid agents, and drug information relevant to prescr...
Source: Expert Review of Neurotherapeutics - April 3, 2024 Category: Neurology Authors: Emily R Schiller Bret David Silverglate George T Grossberg Source Type: research
Utah flouts FDA with law greenlighting placental stem cell therapies
The state of Utah is challenging the authority of the U.S. Food and Drug Administration (FDA) with a new, unusually bold law that allows patients to receive unapproved placental stem cell “therapies.” Observers predict that the law, which takes effect on 1 May, could significantly undermine FDA’s authority to regulate drugs and other treatments.
The
new statute
, passed almost unanimously by both houses of the Utah legislature in February and signed by Governor Spencer Cox (R) last month, declares that Utah health care providers “may perform a [placental] stem cell therapy that is not approved by [F...
Source: Science of Aging Knowledge Environment - April 1, 2024 Category: Geriatrics Source Type: research
Cultured meat in the European Union: Legislative context and food safety issues
Curr Res Food Sci. 2024 Mar 16;8:100722. doi: 10.1016/j.crfs.2024.100722. eCollection 2024.ABSTRACTThe current food system, which is responsible for about one third of all global gas emissions, is considered one of the main causes of resource depletion. For this reason, scientific research is investigating new alternatives capable of feeding an ever-growing population that is set to reach 9-11 billion by 2050. Among these, cell-based meat, also called cultured meat, is one possible solution. It is part of a larger branch of science called cellular agriculture, whose goal is to produce food from individual cells rather than...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: D Lanzoni R Rebucci G Formici F Cheli G Ragone A Baldi L Violini T S Sundaram C Giromini Source Type: research
The Exploration of social media guidelines to ensure Pain Management Nursing is consistent with industry standards
Peer-review journals hold their publishing activities to very high standards. Pain Management Nursing follows industry standards, including COPE Guidelines. However, social media presents a new avenue to promote a journal's content and publishing activities, and social media posting is not covered by current publishing guidelines. The practice of promoting content on social media prompted the PICO question, “Will a peer-reviewed journal that promotes content on social media, compared to traditional search engines and marketing only, maintain scientific integrity?”The purpose of this presentation is to investigate the b...
Source: Pain Management Nursing - April 1, 2024 Category: Nursing Authors: Cecile Evans Source Type: research
Establishing a Value Proposition for a Pain and Comfort Management Private Practice: The Business Canvas
Going into private practice is very different than coming to work every day, picking up your rounding sheet and hoping you complete a plan of care on at least 50% of those on the list to be seen. In private practice, there are so many moving parts. However cash is king, and customers rule the day. Your success depends not just on your expertise but on these two always being in abundant supply. Most would follow the steps of developing a business plan, securing a loan, finding a location, signing a lease, purchasing office furniture, doing marketing, and plan a grand opening. (Source: Pain Management Nursing)
Source: Pain Management Nursing - April 1, 2024 Category: Nursing Authors: Tara Nichols Source Type: research
Normative ratings for the Kitchen and Food Sounds (KFS) database
Behav Res Methods. 2024 Mar 28. doi: 10.3758/s13428-024-02402-7. Online ahead of print.ABSTRACTSounds are important sensory cues for food perception and acceptance. We developed and validated a large-scale database of kitchen and food sounds (180 stimuli) capturing different stages of preparing, cooking, serving, and/or consuming foods and beverages and sounds of packaging, kitchen utensils, and appliances. Each sound was evaluated across nine subjective evaluative dimensions (random order), including stimuli-related properties (e.g., valence, arousal) and food-related items (e.g., healthfulness, appetizingness) by a subsa...
Source: Behavior Research Methods - March 29, 2024 Category: Psychiatry & Psychology Authors: Mar ília Prada David Guedes Margarida Vaz Garrido Magda Saraiva Source Type: research
Normative ratings for the Kitchen and Food Sounds (KFS) database
Behav Res Methods. 2024 Mar 28. doi: 10.3758/s13428-024-02402-7. Online ahead of print.ABSTRACTSounds are important sensory cues for food perception and acceptance. We developed and validated a large-scale database of kitchen and food sounds (180 stimuli) capturing different stages of preparing, cooking, serving, and/or consuming foods and beverages and sounds of packaging, kitchen utensils, and appliances. Each sound was evaluated across nine subjective evaluative dimensions (random order), including stimuli-related properties (e.g., valence, arousal) and food-related items (e.g., healthfulness, appetizingness) by a subsa...
Source: Behavior Research Methods - March 29, 2024 Category: Psychiatry & Psychology Authors: Mar ília Prada David Guedes Margarida Vaz Garrido Magda Saraiva Source Type: research
Normative ratings for the Kitchen and Food Sounds (KFS) database
Behav Res Methods. 2024 Mar 28. doi: 10.3758/s13428-024-02402-7. Online ahead of print.ABSTRACTSounds are important sensory cues for food perception and acceptance. We developed and validated a large-scale database of kitchen and food sounds (180 stimuli) capturing different stages of preparing, cooking, serving, and/or consuming foods and beverages and sounds of packaging, kitchen utensils, and appliances. Each sound was evaluated across nine subjective evaluative dimensions (random order), including stimuli-related properties (e.g., valence, arousal) and food-related items (e.g., healthfulness, appetizingness) by a subsa...
Source: Behavior Research Methods - March 29, 2024 Category: Psychiatry & Psychology Authors: Mar ília Prada David Guedes Margarida Vaz Garrido Magda Saraiva Source Type: research
Research Strategy for Short-Peptide Fusion Inhibitors Based on 6-HB Core Structure against HIV-1: A Review
Curr Pharm Biotechnol. 2024 Mar 28. doi: 10.2174/0113892010297943240325040448. Online ahead of print.ABSTRACTAcquired Immune Deficiency Syndrome (AIDS) is a devastating infectious disease caused by the Human Immunodeficiency Virus type 1 (HIV-1). Enfuvirtide(T20) is the first HIV-1 fusion inhibitor for marketing, which plays an important role in AIDS treatment. However, in the clinical application process, T20 has several drawbacks, such as a high level of development of drug resistance, a short half-life in vivo, and rapid renal clearance, which severely limits the clinical application. Therefore, the development of novel...
Source: Current Pharmaceutical Biotechnology - March 29, 2024 Category: Biotechnology Authors: Guodong Liang Yan Huang Yanbai Tang Lu Ga Caixia Huo Yuheng Ma Yan Zhao Heiya Na Zhao Meng Source Type: research
Research Strategy for Short-Peptide Fusion Inhibitors Based on 6-HB Core Structure against HIV-1: A Review
Curr Pharm Biotechnol. 2024 Mar 28. doi: 10.2174/0113892010297943240325040448. Online ahead of print.ABSTRACTAcquired Immune Deficiency Syndrome (AIDS) is a devastating infectious disease caused by the Human Immunodeficiency Virus type 1 (HIV-1). Enfuvirtide(T20) is the first HIV-1 fusion inhibitor for marketing, which plays an important role in AIDS treatment. However, in the clinical application process, T20 has several drawbacks, such as a high level of development of drug resistance, a short half-life in vivo, and rapid renal clearance, which severely limits the clinical application. Therefore, the development of novel...
Source: Current Pharmaceutical Biotechnology - March 29, 2024 Category: Biotechnology Authors: Guodong Liang Yan Huang Yanbai Tang Lu Ga Caixia Huo Yuheng Ma Yan Zhao Heiya Na Zhao Meng Source Type: research
Research Strategy for Short-Peptide Fusion Inhibitors Based on 6-HB Core Structure against HIV-1: A Review
Curr Pharm Biotechnol. 2024 Mar 28. doi: 10.2174/0113892010297943240325040448. Online ahead of print.ABSTRACTAcquired Immune Deficiency Syndrome (AIDS) is a devastating infectious disease caused by the Human Immunodeficiency Virus type 1 (HIV-1). Enfuvirtide(T20) is the first HIV-1 fusion inhibitor for marketing, which plays an important role in AIDS treatment. However, in the clinical application process, T20 has several drawbacks, such as a high level of development of drug resistance, a short half-life in vivo, and rapid renal clearance, which severely limits the clinical application. Therefore, the development of novel...
Source: Current Pharmaceutical Biotechnology - March 29, 2024 Category: Biotechnology Authors: Guodong Liang Yan Huang Yanbai Tang Lu Ga Caixia Huo Yuheng Ma Yan Zhao Heiya Na Zhao Meng Source Type: research
Normative ratings for the Kitchen and Food Sounds (KFS) database
Behav Res Methods. 2024 Mar 28. doi: 10.3758/s13428-024-02402-7. Online ahead of print.ABSTRACTSounds are important sensory cues for food perception and acceptance. We developed and validated a large-scale database of kitchen and food sounds (180 stimuli) capturing different stages of preparing, cooking, serving, and/or consuming foods and beverages and sounds of packaging, kitchen utensils, and appliances. Each sound was evaluated across nine subjective evaluative dimensions (random order), including stimuli-related properties (e.g., valence, arousal) and food-related items (e.g., healthfulness, appetizingness) by a subsa...
Source: Behavior Research Methods - March 29, 2024 Category: Psychiatry & Psychology Authors: Mar ília Prada David Guedes Margarida Vaz Garrido Magda Saraiva Source Type: research
