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Adapting and Advancing the Criteria for Scientific Evidence, Marketing, and Advice in the Changing World
Clin Ther. 2024 Mar 18:S0149-2918(24)00043-2. doi: 10.1016/j.clinthera.2024.02.005. Online ahead of print.NO ABSTRACTPMID:38503630 | DOI:10.1016/j.clinthera.2024.02.005 (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - March 19, 2024 Category: Drugs & Pharmacology Authors: Jill L Maron Source Type: research

How might FDA fix this e-cigarette PMTA mess? Commentary on Glantz and Lempert and Meshnick et al
In their articles critiquing the US Food and Drugs Administration’s (FDA) first marketing order to allow the legal marketing of any e-cigarette, for Vuse Solo tobacco-flavoured e-cigarettes, Glantz and Lempert and Meshnick et al discuss a range of serious procedural, technical and substantive problems with FDA’s publicly released explanation of how its evaluation of the Vuse application supports that order as appropriate for the protection of the public health.1 2 Those problems are too numerous to list here, but Glantz and Lempert and Meshnick et al reasonably conclude that FDA should withdraw its order allowi...
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Lindblom, E. N. Tags: Open access Commentary Source Type: research

Vuse Solo e-cigarettes do not provide net benefits to public health: a scientific analysis of FDAs marketing authorisation
In October 2021, the US Food and Drug Administration (FDA) authorised marketing of RJ Reynolds Vapor Company’s (RJR) Vuse Solo e-cigarette through FDA’s Premarket Tobacco Product Application (PMTA) pathway. FDA concluded that RJR demonstrated Vuse products met the statutory standard of providing a net benefit to public health. A review of FDA’s scientific justification reveals deficiencies: (1) not adequately considering Vuse’s popularity with youth and evidence that e-cigarettes expanded the nicotine market and stimulate cigarette smoking; (2) trading youth addiction for unproven adult benefit with...
Source: Tobacco Control - March 19, 2024 Category: Respiratory Medicine Authors: Glantz, S., Lempert, L. K. Tags: Special communication Source Type: research

Beyond Tourism: The Importance of Baby Boomer Generation Volunteers
AbstractPopulation aging is regarded as a dominant global demographic trend. One of the least researched population cohort groups in the past are older tourists, who are regarded as a lucrative target market by many volunteer tourism organizations. This systematic literature review provides an analysis of the existing literature and concludes that even though numerous studies have shown the benefits of volunteering for older adults ’ health and well-being, there have been relatively few academic studies that have examined older adult’s (including the baby boomer generation) experiences as volunteer tourists and their e...
Source: Journal of Population Ageing - March 19, 2024 Category: International Medicine & Public Health Source Type: research

Gambling Operators ’ Use of Advertising Strategies on Social Media and Their Effects: A Systematic Review
AbstractPurpose of ReviewSocial media offer gambling operators an attractive channel for connecting with gamblers and promoting their products. The aim of the present study is to review the recent literature to summarise the latest findings on marketing strategies of gambling operators, and their effects, with particular focus on social media.Recent FindingsA systematic review on gambling advertising in social media has been conducted, taking into account English-language journal articles from 2021 onwards, which include primary data collection. Searching three data bases, a total number of 12 studies from peer-reviewed jo...
Source: Current Addiction Reports - March 15, 2024 Category: Addiction Source Type: research

IJERPH, Vol. 21, Pages 352: The Commercial Determinants of Violence: Identifying Opportunities for Violence Prevention through a Public Health-Based Framework Analysis
Kat Ford Violence has immediate and long-term repercussions for the health of individuals and communities. Recent increases in the understanding of public health approaches to violence prevention have focused on the policies and practices of government, health, and other public sector agencies. However, the roles of commercial bodies in fostering and preventing violence remain largely unaddressed. The wealth and influence of some companies now exceeds that of many countries. Consequently, it is timely to explore the roles of commercial processes in violence. Using a conceptual framework for the commercial determinants...
Source: International Journal of Environmental Research and Public Health - March 15, 2024 Category: Environmental Health Authors: Mark A. Bellis Sally McManus Karen Hughes Olumide Adisa Kat Ford Tags: Essay Source Type: research

Analyzing the determinants of beef cattle commercialization and Its market inefficiency: A case study of Pabna district, Bangladesh
by Farjana Eyasmin, Bikash Chandra Ghosh The world has entered a new era of globalization and industrialization, which pose several challenges to ensuring food security. Beef cattle production is one of the fastest-growing subsectors that has the capacity to meet protein demand. Due to growing demand of meat and protein and a market-orie nted production system, small-scale beef cattle production contribute most to marginal farmers as a means of rising income in many developing nations like Bangladesh. Though production and commercialization are not easier for households’ due to various factors and a lack of market effic...
Source: PLoS One - March 15, 2024 Category: Biomedical Science Authors: Farjana Eyasmin Source Type: research

Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity is through inhibition of cardiac ion channels, leading to prolongation of the QT interval and sometimes fatal arrythmias. Recently, oxylipin signaling compounds have been shown to bind to and alter ion channel function, and disruption in their cardiac levels may contribute to QT prolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research

Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research