Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity is through inhibition of cardiac ion channels, leading to prolongation of the QT interval and sometimes fatal arrythmias. Recently, oxylipin signaling compounds have been shown to bind to and alter ion channel function, and disruption in their cardiac levels may contribute to QT prolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity is through inhibition of cardiac ion channels, leading to prolongation of the QT interval and sometimes fatal arrythmias. Recently, oxylipin signaling compounds have been shown to bind to and alter ion channel function, and disruption in their cardiac levels may contribute to QT prolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity is through inhibition of cardiac ion channels, leading to prolongation of the QT interval and sometimes fatal arrythmias. Recently, oxylipin signaling compounds have been shown to bind to and alter ion channel function, and disruption in their cardiac levels may contribute to QT prolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Advancing sustainable water treatment strategies: harnessing magnetite-based photocatalysts and techno-economic analysis for enhanced wastewater management in the context of SDGs
Environ Sci Pollut Res Int. 2024 Mar 12. doi: 10.1007/s11356-024-32680-9. Online ahead of print.ABSTRACTHerein, we explore the holistic integration of magnetite-based photocatalysts and techno-economic analysis (TEA) as a sustainable approach in wastewater treatment aligned with the Sustainable Development Goals (SDGs). While considerable attention has been devoted to photocatalytic dye degradation, the nexus between these processes and techno-economic considerations remains relatively unexplored. The review comprehensively examines the fundamental characteristics of magnetite-based photocatalysts, encompassing synthesis m...
Source: Environmental Science and Pollution Research International - March 13, 2024 Category: Environmental Health Authors: Khumbolake Faith Ngulube Amal Abdelhaleem Ahmed I Osman Lai Peng Mahmoud Nasr Source Type: research
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity is through inhibition of cardiac ion channels, leading to prolongation of the QT interval and sometimes fatal arrythmias. Recently, oxylipin signaling compounds have been shown to bind to and alter ion channel function, and disruption in their cardiac levels may contribute to QT prolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Investigating the association between CYP2J2 inhibitors and QT prolongation: a literature review
Drug Metab Rev. 2024 Mar 20:1-19. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due to cardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity is through inhibition of cardiac ion channels, leading to prolongation of the QT interval and sometimes fatal arrythmias. Recently, oxylipin signaling compounds have been shown to bind to and alter ion channel function, and disruption in their cardiac levels may contribute to QT prolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
