Pain-related single nucleotide polymorphisms: association with lumbar spinal stenosis patient experience and non-surgical treatment outcomes
ConclusionsNPY rs16147 and COMT rs4680 are important potential biomarkers associated with pain and function. NPY genotype may be useful in predicting response to non-surgical treatments in older adults with LSS. (Source: European Spine Journal)
Source: European Spine Journal - April 6, 2024 Category: Orthopaedics Source Type: research
Feasibility, safety, and efficacy of a new percutaneous interspinous device: a retrospective multicenter study
ConclusionLobster PID is an effective and safe minimally invasive decompression method for central canal and neural foraminal stenosis when patients are correctly selected. (Source: Neuroradiology)
Source: Neuroradiology - April 3, 2024 Category: Radiology Source Type: research
Associations Between Comorbid Pain Sites and Pain Bothersomeness with Pain Impact in Adults with Symptomatic Lumbar Spinal Stenosis: Baseline Data Analysis of the Lumbar Stenosis Prognostic Subgroups for Personalizing Care and Treatment Study
We describe the associations of the number of comorbid pain sites and cumulative bothersomeness of those sites with pain impact. This cross-sectional study uses baseline data from a cohort of adults aged ≥50 seeking non-surgical care for LSS at two spine clinics. Comorbid pain locations are summed from a self-reported checklist of 9 locations (range 0-9), and bothersomeness at each site is rated between 0-2 (range 0-18, higher indicates greater bothersomeness). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Natasha L. Parman, Eric N. Meier, Janna L. Friedly, Pradeep Suri, Maggie E. Horn, Colleen A. Burke, Ayumi Saito, Patrick J. Heagerty, Jeffrey G. Jarvik, Adam P. Goode, Amy M. Cizik, Monica Smersh, Sandra K. Johnston, Rebecca Fillipo, Sean D. Rundell Source Type: research
Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis
AbstractNeurogenic intermittent claudication (NIC), a classic symptom of lumbar spinal stenosis (LSS), is associated with neuronal apoptosis. To explore the novel therapeutic target of NIC treatment, we constructed the rat model of NIC by cauda equina compression (CEC) method and collected dorsal root ganglion (DRG) tissues, a region responsible for sensory and motor function, for mRNA sequencing. Bioinformatic analysis of mRNA sequencing indicated that upregulated metallothionein 2A (MT2A), an apoptosis-regulating gene belonging to the metallothionein family, might participate in NIC progression. Activated p38 MAPK mediat...
Source: Human Cell - March 28, 2024 Category: Cytology Source Type: research
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection
CONCLUSION: The ESI was effective in patients with spinal stenosis in short-term follow-up. Dural pulsation of the spinal cord was a positive predictive factor for the ESI effect, but the grade of spinal stenosis severity had no effect on the effectiveness of ESI.PMID:38528984 | PMC:PMC10963105 | DOI:10.1155/2024/1824269 (Source: Pain Research and Management)
Source: Pain Research and Management - March 26, 2024 Category: Anesthesiology Authors: Chan Hong Park Sang Ho Lee Source Type: research
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection
CONCLUSION: The ESI was effective in patients with spinal stenosis in short-term follow-up. Dural pulsation of the spinal cord was a positive predictive factor for the ESI effect, but the grade of spinal stenosis severity had no effect on the effectiveness of ESI.PMID:38528984 | PMC:PMC10963105 | DOI:10.1155/2024/1824269 (Source: Pain Research and Management)
Source: Pain Research and Management - March 26, 2024 Category: Anesthesiology Authors: Chan Hong Park Sang Ho Lee Source Type: research
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection
CONCLUSION: The ESI was effective in patients with spinal stenosis in short-term follow-up. Dural pulsation of the spinal cord was a positive predictive factor for the ESI effect, but the grade of spinal stenosis severity had no effect on the effectiveness of ESI.PMID:38528984 | PMC:PMC10963105 | DOI:10.1155/2024/1824269 (Source: Pain Research and Management)
Source: Pain Research and Management - March 26, 2024 Category: Anesthesiology Authors: Chan Hong Park Sang Ho Lee Source Type: research
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection
CONCLUSION: The ESI was effective in patients with spinal stenosis in short-term follow-up. Dural pulsation of the spinal cord was a positive predictive factor for the ESI effect, but the grade of spinal stenosis severity had no effect on the effectiveness of ESI.PMID:38528984 | PMC:PMC10963105 | DOI:10.1155/2024/1824269 (Source: Pain Research and Management)
Source: Pain Research and Management - March 26, 2024 Category: Anesthesiology Authors: Chan Hong Park Sang Ho Lee Source Type: research
Recovery pattern after decompression of central lumbar spinal stenosis: a prospective observational cohort study
Detailed preoperative information is associated with superior outcomes. We aimed to describe the recovery pattern after decompression of central lumbar spinal stenosis (CLSS). (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - March 25, 2024 Category: Orthopaedics Authors: Niyaz Hareni, Soheil Ebrahimnia, Bj örn E. Rosengren and Magnus K. Karlsson Tags: Research article Source Type: research
Diagnostic and prognostic significance of miR-486-5p in patients who underwent minimally invasive surgery for lumbar spinal stenosis
ConclusionmiR-486-5p, increased in LSS patients, can function as an indicator to diagnose LSS and a predictive indicator for the clinical outcomes after MISS therapy in LSS patients. In addition, miR-486-5p may regulate LSS progression by modulating inflammatory responses. (Source: European Spine Journal)
Source: European Spine Journal - March 25, 2024 Category: Orthopaedics Source Type: research
Preoperative fatty infiltration of paraspinal muscles assessed by MRI is associated with less improvement of leg pain 2 years after surgery for lumbar spinal stenosis
ConclusionPreoperative FI of the paraspinal muscles on MRI showed statistically significant association with postoperative NRS leg pain but not with ODI or ZCQ. (Source: European Spine Journal)
Source: European Spine Journal - March 25, 2024 Category: Orthopaedics Source Type: research
Retrospective Study to Compare the Effectiveness of Minimally Invasive Microscopic Unilateral Laminotomy with Microscopic Bilateral Laminotomy for Bilateral Decompression in the Early Postoperative Period in 142 Patients with Single-Level Lumbar Spinal Stenosis
CONCLUSIONS ULBD may represent a less invasive, more effective, and safer surgical alternative than BLBD and classical laminectomy in patients with single-level LSS, but precautions are essential concerning wound infection.PMID:38491725 | DOI:10.12659/MSM.943815 (Source: Medical Science Monitor)
Source: Medical Science Monitor - March 16, 2024 Category: Research Authors: B ülent Gülensoy Serkan Şimşek Source Type: research
Left-Digit Bias in Surgical Decision-Making for Lumbar Spinal Stenosis
Left-digit bias is a behavioral heuristic or cognitive “shortcut” in which the leftmost digit of a number, such as patient age, disproportionately influences surgical decisions. (Source: The Spine Journal)
Source: The Spine Journal - March 16, 2024 Category: Orthopaedics Authors: Izzet Akosman, Karim Shafi, Tejas Subramanian, Gregory S. Kazarian, Austin C. Kaidi, Matthew Cunningham, Han Jo Kim, Francis Lovecchio Tags: Clinical Study Source Type: research
Walking performance in individuals with lumbar spinal stenosis- possible outcome measures and assessment of known-group validity
One of the primary goals of treatments received by individuals with lumbar spinal stenosis with neurogenic claudication is to improve walking ability. Thus, a thorough and valid assessment of walking ability in patients with lumbar spinal stenosis is needed. Duration of continuous walking and steps per day could be relevant when evaluating walking ability in daily living. (Source: The Spine Journal)
Source: The Spine Journal - March 16, 2024 Category: Orthopaedics Authors: Malin Eleonora av K ák Gustafsson, Berit Schiøttz-Christensen, Therese Lockenwitz Petersen, Randi Jepsen, Niels Wedderkopp, Jan Christian Brønd, Søren Francis Dyhrberg O'Neill Tags: Clinical Study Source Type: research
Comparison of Percutaneous Transforaminal Endoscopic Decompression and Full Endoscopic Lamina Fenestration Decompression in the Treatment of Degenerative Lumbar Spinal Stenosis with Unilateral Radicular Pain: A Retrospective Study
CONCLUSIONS: Both procedures are safe and effective in the treatment of DLSS with unilateral lower extremity radicular pain, and we should be specific about the choice of spinal stenosis treatment.PMID:38469611 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - March 12, 2024 Category: Surgery Authors: Liang Xiong Fengping Liu Hongwei Zhao Mingyi Luo Bin Lu Yuxiang Deng Zhenyu Zhou Source Type: research
