Postoperative complications after surgery for lumbar spinal stenosis, assessment using two different data sources
ConclusionPostoperative complications occurred in 22% of LSS patients. The frequency of different postoperative complications differed between the two data sources. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 23, 2024 Category: Neurosurgery Source Type: research
Lumbar Spinal Stenosis: Diagnosis and Management
Am Fam Physician. 2024 Apr;109(4):350-359.ABSTRACTLumbar spinal stenosis is a clinical syndrome that affects more than 200,000 people in the United States annually. It is a common cause of chronic insidious low back pain, especially in older patient populations (mean age = 64 years). Lumbar spinal stenosis is a degenerative condition of the spine leading to narrowing in the spaces around the neurovascular bundles and the classic symptom of low back pain that radiates to the buttocks and lower extremities bilaterally. It is typically a progressive waxing and waning process that may deteriorate over years. The pain is typica...
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Authors: Charles W Webb Kenneth Aguirre Peter H Seidenberg Source Type: research
Lumbar Spinal Stenosis: Diagnosis and Management
Am Fam Physician. 2024 Apr;109(4):350-359.ABSTRACTLumbar spinal stenosis is a clinical syndrome that affects more than 200,000 people in the United States annually. It is a common cause of chronic insidious low back pain, especially in older patient populations (mean age = 64 years). Lumbar spinal stenosis is a degenerative condition of the spine leading to narrowing in the spaces around the neurovascular bundles and the classic symptom of low back pain that radiates to the buttocks and lower extremities bilaterally. It is typically a progressive waxing and waning process that may deteriorate over years. The pain is typica...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Charles W Webb Kenneth Aguirre Peter H Seidenberg Source Type: research
One-hole split endoscope versus unilateral biportal endoscopy for lumbar spinal stenosis: a retrospective propensity score study
The one-hole split endoscopy (OSE) was first proposed and clinically applied in China in 2019. The aim of this study was to compare the clinical efficacy of one-hole split endoscopy (OSE) and unilateral biport... (Source: Journal of Orthopaedic Surgery and Research)
Source: Journal of Orthopaedic Surgery and Research - April 22, 2024 Category: Orthopaedics Authors: Tusheng Li, Qiang Jiang, Wei Zhong, Tengyue Zhu, Zhengcao Lu and Yu Ding Tags: Research article Source Type: research
Manual therapists ’ appraisal of optimal non-pharmacological conservative management of patients with lumbar spinal stenosis. An international Delphi study.
Lumbar Spinal Stenosis (LSS) is a slow progressive degenerative disorder associated with chronic pain and disability. Although consensus-based international guidelines for invasive treatment of patients with LSS exist, few consensus-based guidelines for optimal conservative management strategies have been published. (Source: Journal of Bodywork and Movement Therapies)
Source: Journal of Bodywork and Movement Therapies - April 19, 2024 Category: Physiotherapy Authors: Konstantinos Prentzas, Zacharias Dimitriadis, Ren ée De Ruijter, Sionnadh McLean Source Type: research
miR-29b-3p Affects the Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis and its Mechanism
Biochem Genet. 2024 Apr 16. doi: 10.1007/s10528-024-10811-8. Online ahead of print.ABSTRACTTo explore the effect of miR-29b-3p on fibrosis and hypertrophy of ligamentum flavum (LF) in lumbar spinal stenosis (LSS) and its underlying mechanism. Patients with LSS and lumbar disc herniation (LDH) (control) undergoing posterior lumbar laminectomy were included in this study. Human LF samples were obtained for LF cell isolation, RNA, and protein extraction. Histomorphological analysis of LF was performed using hematoxylin-eosin (HE) staining. After isolation, culture, and transfection of primary LF cells, different transfection ...
Source: Biochemical Genetics - April 16, 2024 Category: Genetics & Stem Cells Authors: Hongjie Zhang Zhixiong Hong Zehua Jiang Wei Hu Jiashao Hu Rusen Zhu Source Type: research
miR-29b-3p Affects the Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis and its Mechanism
Biochem Genet. 2024 Apr 16. doi: 10.1007/s10528-024-10811-8. Online ahead of print.ABSTRACTTo explore the effect of miR-29b-3p on fibrosis and hypertrophy of ligamentum flavum (LF) in lumbar spinal stenosis (LSS) and its underlying mechanism. Patients with LSS and lumbar disc herniation (LDH) (control) undergoing posterior lumbar laminectomy were included in this study. Human LF samples were obtained for LF cell isolation, RNA, and protein extraction. Histomorphological analysis of LF was performed using hematoxylin-eosin (HE) staining. After isolation, culture, and transfection of primary LF cells, different transfection ...
Source: Biochemical Genetics - April 16, 2024 Category: Genetics & Stem Cells Authors: Hongjie Zhang Zhixiong Hong Zehua Jiang Wei Hu Jiashao Hu Rusen Zhu Source Type: research
Dural Sac Cross-sectional area change from preoperatively and up to 2 years after decompressive surgery for central lumbar spinal stenosis: investigation of operated levels, data from the NORDSTEN study
ConclusionThe spinal canal area after lumbar decompressive surgery for lumbar spinal stenosis increased from baseline to 3 months after surgery and remained thereafter unchanged 2 years postoperatively. (Source: European Spine Journal)
Source: European Spine Journal - April 8, 2024 Category: Orthopaedics Source Type: research
Recovery of the Japanese orthopedic association back pain evaluation questionnaire score and walking ability following lumbar spinal stenosis surgery
ConclusionOur results demonstrated the early postoperative recovery course of JOABPEQ and 6MWD. In the fusion group, significant changes in lumbar spine dysfunction started at 6 months postoperatively. These findings could help medical staff explain postoperative recovery to patients after lumbar spinal stenosis surgery and in their decision making regarding surgery. (Source: European Spine Journal)
Source: European Spine Journal - April 7, 2024 Category: Orthopaedics Source Type: research
Pain-related single nucleotide polymorphisms: association with lumbar spinal stenosis patient experience and non-surgical treatment outcomes
ConclusionsNPY rs16147 and COMT rs4680 are important potential biomarkers associated with pain and function. NPY genotype may be useful in predicting response to non-surgical treatments in older adults with LSS. (Source: European Spine Journal)
Source: European Spine Journal - April 6, 2024 Category: Orthopaedics Source Type: research
Feasibility, safety, and efficacy of a new percutaneous interspinous device: a retrospective multicenter study
ConclusionLobster PID is an effective and safe minimally invasive decompression method for central canal and neural foraminal stenosis when patients are correctly selected. (Source: Neuroradiology)
Source: Neuroradiology - April 3, 2024 Category: Radiology Source Type: research
Associations Between Comorbid Pain Sites and Pain Bothersomeness with Pain Impact in Adults with Symptomatic Lumbar Spinal Stenosis: Baseline Data Analysis of the Lumbar Stenosis Prognostic Subgroups for Personalizing Care and Treatment Study
We describe the associations of the number of comorbid pain sites and cumulative bothersomeness of those sites with pain impact. This cross-sectional study uses baseline data from a cohort of adults aged ≥50 seeking non-surgical care for LSS at two spine clinics. Comorbid pain locations are summed from a self-reported checklist of 9 locations (range 0-9), and bothersomeness at each site is rated between 0-2 (range 0-18, higher indicates greater bothersomeness). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Natasha L. Parman, Eric N. Meier, Janna L. Friedly, Pradeep Suri, Maggie E. Horn, Colleen A. Burke, Ayumi Saito, Patrick J. Heagerty, Jeffrey G. Jarvik, Adam P. Goode, Amy M. Cizik, Monica Smersh, Sandra K. Johnston, Rebecca Fillipo, Sean D. Rundell Source Type: research
Compensatory upregulation of MT2A alleviates neurogenic intermittent claudication through inhibiting activated p38 MAPK-mediated neuronal apoptosis
AbstractNeurogenic intermittent claudication (NIC), a classic symptom of lumbar spinal stenosis (LSS), is associated with neuronal apoptosis. To explore the novel therapeutic target of NIC treatment, we constructed the rat model of NIC by cauda equina compression (CEC) method and collected dorsal root ganglion (DRG) tissues, a region responsible for sensory and motor function, for mRNA sequencing. Bioinformatic analysis of mRNA sequencing indicated that upregulated metallothionein 2A (MT2A), an apoptosis-regulating gene belonging to the metallothionein family, might participate in NIC progression. Activated p38 MAPK mediat...
Source: Human Cell - March 28, 2024 Category: Cytology Source Type: research
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection
CONCLUSION: The ESI was effective in patients with spinal stenosis in short-term follow-up. Dural pulsation of the spinal cord was a positive predictive factor for the ESI effect, but the grade of spinal stenosis severity had no effect on the effectiveness of ESI.PMID:38528984 | PMC:PMC10963105 | DOI:10.1155/2024/1824269 (Source: Pain Research and Management)
Source: Pain Research and Management - March 26, 2024 Category: Anesthesiology Authors: Chan Hong Park Sang Ho Lee Source Type: research
Relationships between the Spinal Dural Pulsations and the Short-Term Efficacy of Lumbar Epidural Steroid Injection
CONCLUSION: The ESI was effective in patients with spinal stenosis in short-term follow-up. Dural pulsation of the spinal cord was a positive predictive factor for the ESI effect, but the grade of spinal stenosis severity had no effect on the effectiveness of ESI.PMID:38528984 | PMC:PMC10963105 | DOI:10.1155/2024/1824269 (Source: Pain Research and Management)
Source: Pain Research and Management - March 26, 2024 Category: Anesthesiology Authors: Chan Hong Park Sang Ho Lee Source Type: research
