Isolated non-immune mediated second-degree atrioventricular block in fetus: natural history and predictive factors for spontaneous recovery
CONCLUSIONS: The outcome of fetal non-immune second-degree AVB was favorable. Earlier gestational age at diagnosis and higher atrial rate were related to spontaneous reversion for isolated non-immune-mediated second-degree AVB. However, prenatal gene test should be performed for those with persistent AVB to exclude the heritable disorders including LQTS. These findings may provide important references for clinical management and prenatal counseling. This article is protected by copyright. All rights reserved.PMID:38642334 | DOI:10.1002/uog.27662 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 20, 2024 Category: Radiology Authors: S Shao H Liao S Zhou Y Li H Yu X Dai Q Zhu Y Hua C Wang K Zhou Source Type: research
Isolated non-immune mediated second-degree atrioventricular block in fetus: natural history and predictive factors for spontaneous recovery
CONCLUSIONS: The outcome of fetal non-immune second-degree AVB was favorable. Earlier gestational age at diagnosis and higher atrial rate were related to spontaneous reversion for isolated non-immune-mediated second-degree AVB. However, prenatal gene test should be performed for those with persistent AVB to exclude the heritable disorders including LQTS. These findings may provide important references for clinical management and prenatal counseling. This article is protected by copyright. All rights reserved.PMID:38642334 | DOI:10.1002/uog.27662 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 20, 2024 Category: Radiology Authors: S Shao H Liao S Zhou Y Li H Yu X Dai Q Zhu Y Hua C Wang K Zhou Source Type: research
Invited commentary on: sudden cardiac death
Postmortem examination holds a pivotal role in our society. The implications of this procedure are vast, ranging from medicolegal consequences to characterisation of heritable genetic syndromes and closure for those proximal to the deceased. Despite its widespread intrinsic value, a surprising 1%–5% of postmortem examinations will lack revealing gross, histologic, or laboratory findings that inform the cause of death.1 2 The so-called ‘negative autopsy’ is a challenge for the medical system and relatives of the deceased alike. A specific list of differential diagnoses is considered in the setting of a neg...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Bois, M.D., M. C. Tags: Grand rounds commentary Source Type: research
Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
Cardiovasc Toxicol. 2024 Apr 17. doi: 10.1007/s12012-024-09853-6. Online ahead of print.ABSTRACTThe challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition, widespread clinical use, and potential abuse. In response, healthcare professionals have primarily concentrated on mitigating the hallucinogenic and respiratory depressant consequences of opioid overdose to minimize associated risks. However, it is crucial to acknowledge that most opioids possess the capacity to prolong the QT interval, particularly in cases of overdose, thereby pot...
Source: Cardiovascular Toxicology - April 17, 2024 Category: Cardiology Authors: Jiale Hu Yongfei Song Xiaoyan Huang Chongrong Li Xiaojun Jin Lichao Cen Chuanjin Zhang Beilei Ding Jiangfang Lian Source Type: research
Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
Cardiovasc Toxicol. 2024 Apr 17. doi: 10.1007/s12012-024-09853-6. Online ahead of print.ABSTRACTThe challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition, widespread clinical use, and potential abuse. In response, healthcare professionals have primarily concentrated on mitigating the hallucinogenic and respiratory depressant consequences of opioid overdose to minimize associated risks. However, it is crucial to acknowledge that most opioids possess the capacity to prolong the QT interval, particularly in cases of overdose, thereby pot...
Source: Cardiovascular Toxicology - April 17, 2024 Category: Cardiology Authors: Jiale Hu Yongfei Song Xiaoyan Huang Chongrong Li Xiaojun Jin Lichao Cen Chuanjin Zhang Beilei Ding Jiangfang Lian Source Type: research
A novel mutation in hERG gene associated with azithromycin-induced acquired long QT syndrome
CONCLUSIONS: These findings suggest that hERG gene mutations might be involved in the genetic susceptibility mechanism underlying acquired LQTS induced by azithromycin.PMID:38625436 | DOI:10.1007/s11033-024-09421-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 16, 2024 Category: Molecular Biology Authors: Yun-Jiu Cheng Yang Wu Hui-Qiang Wei Yi-Jian Liao Li-Ping Qu Yue-Han Pan Li-Juan Liu Wen-Tao Bi Source Type: research
The ion channel basis of pharmacological effects of amiodarone on myocardial electrophysiological properties, a comprehensive review
Biomed Pharmacother. 2024 Apr 1;174:116513. doi: 10.1016/j.biopha.2024.116513. Online ahead of print.ABSTRACTAmiodarone is a benzofuran-based class III antiarrhythmic agent frequently used for the treatment of atrial and ventricular arrhythmias. The primary target of class III antiarrhythmic drugs is the cardiac human ether-a-go-go-related gene (hERG) encoded channel, KCNH2, commonly known as HERG, that conducts the rapidly activating delayed rectifier potassium current (IKr). Like other class III antiarrhythmic drugs, amiodarone exerts its physiologic effects mainly through IKr blockade, delaying the repolarization phase ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 2, 2024 Category: Drugs & Pharmacology Authors: Illia Gelman Neelakshi Sharma Olivia Mckeeman Peter Lee Noah Campagna Nicole Tomei Adrian Baranchuk Shetuan Zhang Mohammad El-Diasty Source Type: research
Prioritize Variant Reclassification in Pediatric Long QT Syndrome —Time to Revisit
AbstractCongenital long QT syndrome (LQTS) is an inherited arrhythmia syndrome associated with sudden cardiac death. Accurate interpretation and classification of genetic variants in LQTS patients are crucial for effective management. All patients with LQTS with a positive genetic test over the past 18 years (2002–2020) in our single tertiary pediatric cardiac center were identified. Reevaluation of the reported variants in LQTS genes was conducted using the American College of Genetics and Genomics (ACMG) guideline after refinement by the US ClinGen SVI working group and guideline by Walsh et al. on genetic variant re...
Source: Pediatric Cardiology - April 2, 2024 Category: Cardiology Source Type: research
A Patient with Ebstein's Anomaly Receives a Transplanted Heart with Unexpected Long QT
We present a woman with a history of Ebstein ’s anomaly who was a recipient of a heart from an individual who was later determined to have the KCNQ1 gene associated with congenital long QT syndrome. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: E. Hassell, , M. Aktas, L. Chen, A. Godishala Source Type: research
A Case of Ventricular Fibrillation in Masked Long-QT Syndrome Coexisting with Coronary Vasospasm
Int Heart J. 2024;65(2):354-358. doi: 10.1536/ihj.23-397.ABSTRACTAlthough long-QT syndrome (LQTS) with a normal range QT interval at rest leads to fatal ventricular arrhythmias, it is difficult to diagnose. In this article, we present a rare case of a patient who suffered a cardiac arrest and was recently diagnosed with LQTS and coronary vasospasm. A 62-year-old man with no syncopal episodes had a cardiopulmonary arrest while running. During coronary angiography, vasospasm was induced and we prescribed coronary vasodilators, including calcium channel blockers. An exercise stress test was performed to evaluate the effect of...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Atsumasa Kurozumi Yoshinari Enomoto Hisao Hara Norihiro Kato Yukio Hiroi Source Type: research
