Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
AbstractDespite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i.e., mainly amiodarone refractory ventricular arrh...
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research

Proceed with caution: Standard protocol exercise stress tests fail to replicate the diagnostic utility of supine ‐stand tests for long QT syndrome
ConclusionTESTs should be used with caution when trying to interpret supine-stand changes for diagnosis of LQTS. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - February 13, 2024 Category: Cardiology Authors: Alexa M. Pinsky, Veda K. Kulkarni, J. Martijn Bos, Raquel Neves, Thomas G. Allison, Michael J. Ackerman Tags: ORIGINAL ARTICLE Source Type: research

Continuous Variant Re-Classification: An Effective Tool in the Ongoing Quest to Escape Genetic Purgatory
Genotype, albeit to varying degrees, impacts the diagnosis, risk-stratification, and management of many genetic heart diseases (GHDs).1 Accordingly, since the start of the new millennium, genetic testing has evolved from a research-based investigational test to a class I recommended, standard of care clinical test for patients with inherited cardiac channelopathies and cardiomyopathies such as arrhythmogenic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, dilated cardiomyopathy, hypertrophic cardiomyopathy, and long QT syndrome (LQTS). (Source: Heart Rhythm)
Source: Heart Rhythm - January 31, 2024 Category: Cardiology Authors: Michael J. Ackerman, John R. Giudicessi Source Type: research

Continuous variant reclassification: An effective tool in the ongoing quest to escape genetic purgatory
Genotype, albeit to varying degrees, affects the diagnosis, risk stratification, and management of many genetic heart diseases (GHDs).1 Accordingly, since the start of the new millennium, genetic testing has evolved from a research-based investigational test to a class I recommended, standard-of-care clinical test for patients with inherited cardiac channelopathies and cardiomyopathies such as arrhythmogenic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, dilated cardiomyopathy, hypertrophic cardiomyopathy, and long QT syndrome (LQTS). (Source: Heart Rhythm)
Source: Heart Rhythm - January 31, 2024 Category: Cardiology Authors: Michael J. Ackerman, John R. Giudicessi Tags: Editorial Commentary Source Type: research

Top stories on congenital long QT syndrome
This is a one-eyed, understandably skewed selection of recent articles on long QT syndrome (LQTS) all sharing very practical clinical implications. (Source: Heart Rhythm)
Source: Heart Rhythm - January 29, 2024 Category: Cardiology Authors: Peter J. Schwartz, Federica Dagradi, Fulvio L.F. Giovenzana Tags: Top Stories Source Type: research

The Irate Stellate Ganglion: IL-6 in Neuroinflammation-induced Ventricular Arrhythmias
Sympathetic nervous system hyperactivity plays a major role in the pathogenesis of ventricular arrhythmias following myocardial infarction (MI).1,2 The stellate ganglia are an important nexus point for sympathetic innervation to the heart.3 Neuroinflammation has been implicated as a mechanism for sympathetic activation in cardiovascular disease. Inflammation within the stellate ganglia has been observed in patients with sudden cardiac death after MI,4,5 long QT syndrome and catecholaminergic polymorphic ventricular tachycardia,6 and electrical storm,7 suggesting a link between inflammation within these ganglia and ventricu...
Source: Heart Rhythm - January 27, 2024 Category: Cardiology Authors: Pradeep S. Rajendran, Peter Hanna Source Type: research

The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies
Cardiovasc Res. 2024 Jan 9:cvae009. doi: 10.1093/cvr/cvae009. Online ahead of print.ABSTRACTVentricular arrhythmias in cardiac channelopathies are linked to autonomic triggers, which are sub-optimally targeted in current management strategies. Improved molecular understanding of cardiac channelopathies and cellular autonomic signalling could refine autonomic therapies to target the specific signalling pathways relevant to the specific aetiologies as well as the central nervous system centres involved in the cardiac autonomic regulation. This review summarizes key anatomical and physiological aspects of the cardiac autonomi...
Source: Cell Research - January 10, 2024 Category: Cytology Authors: Johanna B Tonko Pier D Lambiase Source Type: research

Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research

Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research

Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research

Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research

Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research

A case of short QT ‐interval postventricular arrhythmia arrest from Torsade De Pointes, a new phenotype, or the result of tachycardia‐mediated imbalance
ConclusionsA transient, potentially artificial, short QT interval following Torsades de Pointes can occur in patients with LQTS. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - January 4, 2024 Category: Cardiology Authors: Ikechukwu Ifedili, Miguel Maturana, Sharif Kayali, Yehoshua Levine, Rajesh Kabra, Sunil K. Jha Tags: CASE REPORT Source Type: research

How Can We Evaluate Arrhythmic Risk in Children With Long QT Syndrome?
Circ J. 2023 Dec 29. doi: 10.1253/circj.CJ-23-0884. Online ahead of print.NO ABSTRACTPMID:38171808 | DOI:10.1253/circj.CJ-23-0884 (Source: Circulation Journal)
Source: Circulation Journal - January 3, 2024 Category: Cardiology Authors: Keiko Shimamoto Takeshi Aiba Source Type: research

How Can We Evaluate Arrhythmic Risk in Children With Long QT Syndrome?
Circ J. 2023 Dec 29. doi: 10.1253/circj.CJ-23-0884. Online ahead of print.NO ABSTRACTPMID:38171808 | DOI:10.1253/circj.CJ-23-0884 (Source: Circulation Journal)
Source: Circulation Journal - January 3, 2024 Category: Cardiology Authors: Keiko Shimamoto Takeshi Aiba Source Type: research