Fetal Long QT Syndrome - Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy
Z Geburtshilfe Neonatol. 2024 Feb 22. doi: 10.1055/a-2231-9348. Online ahead of print.ABSTRACTCongenital LQTS is an often undetected inherited cardiac channel dysfunction and can be a reason for intrauterine fetal demise. It can present in utero as CTG and ultrasound abnormalities, i. e., bradycardia, ventricular tachycardia, or fetal hydrops. Diagnosis is made by CTG, echocardiography, or fMCG. Intrauterine therapy with a ß blocker and i. v. magnesium should be started. Our objective was to examine the current knowledge about diagnosis and treatment of LQTS and in particular to highlight the opportunity of vaginal birth ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - February 22, 2024 Category: Perinatology & Neonatology Authors: Linda Sarah Wegner Johannes Steinhard Thomas Frank Kai Thorsten Laser Karol Kubiak Source Type: research
Fetal Long QT Syndrome - Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy
Z Geburtshilfe Neonatol. 2024 Feb 22. doi: 10.1055/a-2231-9348. Online ahead of print.ABSTRACTCongenital LQTS is an often undetected inherited cardiac channel dysfunction and can be a reason for intrauterine fetal demise. It can present in utero as CTG and ultrasound abnormalities, i. e., bradycardia, ventricular tachycardia, or fetal hydrops. Diagnosis is made by CTG, echocardiography, or fMCG. Intrauterine therapy with a ß blocker and i. v. magnesium should be started. Our objective was to examine the current knowledge about diagnosis and treatment of LQTS and in particular to highlight the opportunity of vaginal birth ...
Source: Zeitschrift fur Geburtshilfe und Neonatologie - February 22, 2024 Category: Perinatology & Neonatology Authors: Linda Sarah Wegner Johannes Steinhard Thomas Frank Kai Thorsten Laser Karol Kubiak Source Type: research
Sensors, Vol. 24, Pages 1318: Wearable Technology for Monitoring Electrocardiograms (ECGs) in Adults: A Scoping Review
Anand
In the rapidly evolving landscape of continuous electrocardiogram (ECG) monitoring systems, there is a heightened demand for non-invasive sensors capable of measuring ECGs and detecting heart rate variability (HRV) in diverse populations, ranging from cardiovascular patients to sports enthusiasts. Challenges like device accuracy, patient privacy, signal noise, and long-term safety impede the use of wearable devices in clinical practice. This scoping review aims to assess the performance and safety of novel multi-channel, sensor-based biopotential wearable devices in adults. A comprehensive search strategy was ...
Source: Sensors - February 18, 2024 Category: Biotechnology Authors: Dahiya Kalra Lowe Anand Tags: Review Source Type: research
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
AbstractDespite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i.e., mainly amiodarone refractory ventricular arrh...
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants
Variants in the KCNQ1 gene, encoding the α-subunit of the slow component of delayed rectifier K+ channel, Kv7.1, cause long-QT syndrome type 1 (LQT1). The location of variants may be one of factors in determining prognosis. However, detailed genotype-phenotype relationships associated with C-terminus variants remain unelucidated. (Source: Heart Rhythm)
Source: Heart Rhythm - February 14, 2024 Category: Cardiology Authors: Asami Kashiwa, Hideki Itoh, Takeru Makiyama, Yuko Wada, Junichi Ozawa, Koichi Kato, Megumi Fukuyama, Tadashi Nakajima, Seiko Ohno, Minoru Horie Source Type: research
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias
AbstractDespite impressive developments in the field of ventricular arrhythmias, there is still a relevant number of patients with ventricular arrhythmias who require antiarrhythmic drug therapy and may, e.g., in otherwise drug and/or ablation refractory situations, benefit from agents known for decades, such as mexiletine. Through its capability of blocking fast sodium channels in cardiomyocytes, it has played a minor to moderate antiarrhythmic role throughout the recent decades. Nevertheless, certain patients with structural heart disease suffering from drug-refractory, i.e., mainly amiodarone refractory ventricular arrh...
Source: Clinical Research in Cardiology - February 14, 2024 Category: Cardiology Source Type: research
Proceed with caution: Standard protocol exercise stress tests fail to replicate the diagnostic utility of supine ‐stand tests for long QT syndrome
ConclusionTESTs should be used with caution when trying to interpret supine-stand changes for diagnosis of LQTS. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - February 13, 2024 Category: Cardiology Authors: Alexa M. Pinsky,
Veda K. Kulkarni,
J. Martijn Bos,
Raquel Neves,
Thomas G. Allison,
Michael J. Ackerman Tags: ORIGINAL ARTICLE Source Type: research
Continuous Variant Re-Classification: An Effective Tool in the Ongoing Quest to Escape Genetic Purgatory
Genotype, albeit to varying degrees, impacts the diagnosis, risk-stratification, and management of many genetic heart diseases (GHDs).1 Accordingly, since the start of the new millennium, genetic testing has evolved from a research-based investigational test to a class I recommended, standard of care clinical test for patients with inherited cardiac channelopathies and cardiomyopathies such as arrhythmogenic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, dilated cardiomyopathy, hypertrophic cardiomyopathy, and long QT syndrome (LQTS). (Source: Heart Rhythm)
Source: Heart Rhythm - January 31, 2024 Category: Cardiology Authors: Michael J. Ackerman, John R. Giudicessi Source Type: research
Continuous variant reclassification: An effective tool in the ongoing quest to escape genetic purgatory
Genotype, albeit to varying degrees, affects the diagnosis, risk stratification, and management of many genetic heart diseases (GHDs).1 Accordingly, since the start of the new millennium, genetic testing has evolved from a research-based investigational test to a class I recommended, standard-of-care clinical test for patients with inherited cardiac channelopathies and cardiomyopathies such as arrhythmogenic cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, dilated cardiomyopathy, hypertrophic cardiomyopathy, and long QT syndrome (LQTS). (Source: Heart Rhythm)
Source: Heart Rhythm - January 31, 2024 Category: Cardiology Authors: Michael J. Ackerman, John R. Giudicessi Tags: Editorial Commentary Source Type: research
Top stories on congenital long QT syndrome
This is a one-eyed, understandably skewed selection of recent articles on long QT syndrome (LQTS) all sharing very practical clinical implications. (Source: Heart Rhythm)
Source: Heart Rhythm - January 29, 2024 Category: Cardiology Authors: Peter J. Schwartz, Federica Dagradi, Fulvio L.F. Giovenzana Tags: Top Stories Source Type: research
The Irate Stellate Ganglion: IL-6 in Neuroinflammation-induced Ventricular Arrhythmias
Sympathetic nervous system hyperactivity plays a major role in the pathogenesis of ventricular arrhythmias following myocardial infarction (MI).1,2 The stellate ganglia are an important nexus point for sympathetic innervation to the heart.3 Neuroinflammation has been implicated as a mechanism for sympathetic activation in cardiovascular disease. Inflammation within the stellate ganglia has been observed in patients with sudden cardiac death after MI,4,5 long QT syndrome and catecholaminergic polymorphic ventricular tachycardia,6 and electrical storm,7 suggesting a link between inflammation within these ganglia and ventricu...
Source: Heart Rhythm - January 27, 2024 Category: Cardiology Authors: Pradeep S. Rajendran, Peter Hanna Source Type: research
The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies
Cardiovasc Res. 2024 Jan 9:cvae009. doi: 10.1093/cvr/cvae009. Online ahead of print.ABSTRACTVentricular arrhythmias in cardiac channelopathies are linked to autonomic triggers, which are sub-optimally targeted in current management strategies. Improved molecular understanding of cardiac channelopathies and cellular autonomic signalling could refine autonomic therapies to target the specific signalling pathways relevant to the specific aetiologies as well as the central nervous system centres involved in the cardiac autonomic regulation. This review summarizes key anatomical and physiological aspects of the cardiac autonomi...
Source: Cell Research - January 10, 2024 Category: Cytology Authors: Johanna B Tonko Pier D Lambiase Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials
CONCLUSIONS: This meta-analysis found that propofol had a minimal effect on QTc prolongation, followed by sevoflurane and desflurane in adults with normal QTc interval and without cardiovascular diseases. Propofol is the best anesthetic for adult patients with long QT syndrome or cardiac diseases, but still needs more robust evidence.PMID:38178332 | DOI:10.59958/hsf.6969 (Source: The Heart Surgery Forum)
Source: The Heart Surgery Forum - January 5, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Yongheng Cai Zongping Yi Hanwen Ou Yong Dou He Huang Bing Chen Source Type: research
