The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

The Antiarrhythmic Action of the Na < sup > + < /sup > /Ca < sup > 2+ < /sup > Exchanger Inhibitor SEA0400 on Drug-Induced Long QT Syndrome Depends on the Severity of Proarrhythmic Conditions in Anesthetized Atrioventricular Block Rabbits
Biol Pharm Bull. 2023;46(8):1120-1127. doi: 10.1248/bpb.b23-00202.ABSTRACTTo clarify the pharmacological properties of the Na+/Ca2+ exchanger (NCX) inhibitor SEA0400 as an antiarrhythmic agent, we assessed its effects on rapid component of delayed rectifier K+ current (IKr) blocker-induced torsade de pointes (TdP) in isoflurane-anesthetized rabbits. Atrioventricular block was induced in rabbits using a catheter ablation technique, and the monophasic action potential (MAP) of the right ventricle was measured under electrical pacing at 60 beats/min. In non-treated control animals, intravenous administration of low-dose (0.3 ...
Source: Biological and Pharmaceutical Bulletin - August 2, 2023 Category: Drugs & Pharmacology Authors: Satoshi Kawakami Kazuhiro Takada Megumi Aimoto Yoshinobu Nagasawa Taichi Kusakabe Keisuke Kato Akira Takahara Source Type: research

What are Common Pitfalls in Measuring the QTc in Hospitalized Adult Patients?
Case Ms. S. is a 60-year-old woman admitted with gastroenteritis and hypovolemia in the setting of three days of nausea and diarrhea. She was also found to have atrial fibrillation with rapid ventricular response. Her tachycardia improved after intravenous fluids. The following morning, nausea prompted her nurse to request antiemetic medications. You inspect the admission electrocardiogram (ECG) (Figure 1). Are QT-prolonging antiemetics safe to administer? In this review, we provide background and practical guidance regarding QT interval (QTc) interpretation for the internist caring for hospitalized adults.  Accurate meas...
Source: The Hospitalist - August 1, 2023 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Key Clinical Questions Source Type: research

SCN5A-1795insD founder variant: a  unique Dutch experience spanning 7 decades
Neth Heart J. 2023 Jul 20. doi: 10.1007/s12471-023-01799-8. Online ahead of print.ABSTRACTThe SCN5A-1795insD founder variant is a unique SCN5A gene variant found in a large Dutch pedigree that first came to attention in the late 1950s. To date, this is still one of the largest and best described SCN5A founder families worldwide. It was the first time that a single pathogenic variant in SCN5A proved to be sufficient to cause a sodium channel overlap syndrome. Affected family members displayed features of Brugada syndrome, cardiac conduction disease and long QT syndrome type 3, thus encompassing features of both loss and gai...
Source: Netherlands Heart Journal - July 20, 2023 Category: Cardiology Authors: Virginnio M Proost Maarten P van den Berg Carol Ann Remme Arthur A M Wilde Source Type: research

SCN5A-1795insD founder variant: a  unique Dutch experience spanning 7 decades
Neth Heart J. 2023 Jul 20. doi: 10.1007/s12471-023-01799-8. Online ahead of print.ABSTRACTThe SCN5A-1795insD founder variant is a unique SCN5A gene variant found in a large Dutch pedigree that first came to attention in the late 1950s. To date, this is still one of the largest and best described SCN5A founder families worldwide. It was the first time that a single pathogenic variant in SCN5A proved to be sufficient to cause a sodium channel overlap syndrome. Affected family members displayed features of Brugada syndrome, cardiac conduction disease and long QT syndrome type 3, thus encompassing features of both loss and gai...
Source: Netherlands Heart Journal - July 20, 2023 Category: Cardiology Authors: Virginnio M Proost Maarten P van den Berg Carol Ann Remme Arthur A M Wilde Source Type: research

SCN5A-1795insD founder variant: a  unique Dutch experience spanning 7 decades
Neth Heart J. 2023 Jul 20. doi: 10.1007/s12471-023-01799-8. Online ahead of print.ABSTRACTThe SCN5A-1795insD founder variant is a unique SCN5A gene variant found in a large Dutch pedigree that first came to attention in the late 1950s. To date, this is still one of the largest and best described SCN5A founder families worldwide. It was the first time that a single pathogenic variant in SCN5A proved to be sufficient to cause a sodium channel overlap syndrome. Affected family members displayed features of Brugada syndrome, cardiac conduction disease and long QT syndrome type 3, thus encompassing features of both loss and gai...
Source: Netherlands Heart Journal - July 20, 2023 Category: Cardiology Authors: Virginnio M Proost Maarten P van den Berg Carol Ann Remme Arthur A M Wilde Source Type: research

Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research

Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research

Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research

Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research