Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants

Variants in the KCNQ1 gene, encoding the α-subunit of the slow component of delayed rectifier K+ channel, Kv7.1, cause long-QT syndrome type 1 (LQT1). The location of variants may be one of factors in determining prognosis. However, detailed genotype-phenotype relationships associated with C-terminus variants remain unelucidated.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research