Assessment of quinidine-induced TdP risks using a whole-body physiologically based pharmacokinetic model linked to cardiac ionic current inhibition
In conclusion, the developed PBPK-PD model may be applied to predict the quinidine pharmacokinetics and quinidine-induced TdP risks in healthy subjects, but also simulate quinidine-induced TdP risks under disease conditions such as hypokalemia and alkalosis.PMID:38117225 | DOI:10.1002/cpt.3156 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - December 20, 2023 Category: Drugs & Pharmacology Authors: Zexin Zhang Han Zhou Yiting Yang Li Liu Xiaodong Liu Source Type: research

Long QT syndrome after using EGFR-TKIs in older patients with advanced non-small cell lung cancer
CONCLUSIONS: Given the elevated risk of LQTS associated with osimertinib user, close monitoring for cardiac rhythm irregularities of high-risk patients following initiation of EGFR-TKI is recommended.PMID:38088244 | DOI:10.1080/14740338.2023.2294924 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - December 13, 2023 Category: Drugs & Pharmacology Authors: Joo-Young Byun Sola Han Aiham Qdaisat Chanhyun Park Source Type: research

Right ventricular systolic function as a predictor of appropriate ICD therapy
ConclusionA low RVFAC might be associated with increased appropriate ICD therapy.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - December 13, 2023 Category: Cardiology Source Type: research

Functional and clinical characterization of a novel homozygous KCNH2 missense variant in the pore region of Kv11.1 leading to a viable but severe long-QT syndrome
CONCLUSIONS: We characterized the novel p.Gly603Ser KCNH2 missense LOF variant in the pore region of Kv11.1/hERG leading to a severe but viable LQTS in the homozygous state and an attenuated Type 2 LQTS in heterozygous carriers. To our knowledge we provide the first description of a homozygous variant in the pore-forming region of Kv11.1 with a functional impact but a delayed clinical expression.PMID:38086455 | DOI:10.1016/j.gene.2023.148076 (Source: Gene)
Source: Gene - December 12, 2023 Category: Genetics & Stem Cells Authors: A Delini ère L Jaupart A Janin G Millat T Boulin O Andrini P Chevalier Source Type: research

Functional and clinical characterization of a novel homozygous KCNH2 missense variant in the pore region of Kv11.1 leading to a viable but severe long-QT syndrome
CONCLUSIONS: We characterized the novel p.Gly603Ser KCNH2 missense LOF variant in the pore region of Kv11.1/hERG leading to a severe but viable LQTS in the homozygous state and an attenuated Type 2 LQTS in heterozygous carriers. To our knowledge we provide the first description of a homozygous variant in the pore-forming region of Kv11.1 with a functional impact but a delayed clinical expression.PMID:38086455 | DOI:10.1016/j.gene.2023.148076 (Source: Gene)
Source: Gene - December 12, 2023 Category: Genetics & Stem Cells Authors: A Delini ère L Jaupart A Janin G Millat T Boulin O Andrini P Chevalier Source Type: research

QT interval prolongation in Takotsubo syndrome: a frightening feature with no major prognostic impact
Monaldi Arch Chest Dis. 2023 Dec 6. doi: 10.4081/monaldi.2023.2834. Online ahead of print.ABSTRACTDespite the frequent and often severe repolarization abnormalities seen in Takotsubo syndrome (TTS), the underlying mechanism of life-threatening arrhythmias is incompletely understood, and the risk remains uncertain. TTS is considered a potential cause of acquired long QT syndrome; however, there is no robust evidence that QT prolongation has a major prognostic impact on these patients' outcomes. Our aim was to assess the prevalence and clinical implications of acquired long QT during TTS events and compare in-hospital and lo...
Source: Monaldi Archives for Chest Disease - December 7, 2023 Category: Respiratory Medicine Authors: Ana Isabel Pinho C átia Oliveira Lu ís Daniel Santos Catarina Marques Andr é Cabrita Paula Dias Gon çalo Pestana Carla Sousa Rui Andr é Rodrigues Source Type: research