Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports
ConclusionsWe observed two cases of recurrent severe hypocalcemia in patients with advanced breast cancer and bone metastases after modifications to their therapy regimens. These cases differed from the typical hypocalcemia induced by bone-modifying agents. It is possible that antitumor drugs affect calcium and bone metabolism associated with bone metastases. While these cases are rare, it is crucial for oncologists to be aware of hypocalcemia not only at the initiation of bone-modifying agents but also throughout the entire antitumor therapy, as hypocalcemia can lead to fatal outcomes. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 25, 2024 Category: General Medicine Source Type: research
Comparison of Clinicopathological Features of Pleomorphic and Invasive Lobular Breast Carcinomas
CONCLUSION: We discovered that pleomorphic type was associated with higher grades, estrogen receptor negativity, and Ki-67 expression. The incidence of metachronous breast cancer was high in the pleomorphic group, which may be a noteworthy finding to be considered in follow-ups. In addition, the high rates of multicentricity and multifocality of tumors in the pleomorphic group may be associated with increased surgical margin positivity and a higher likelihood of mastectomy. In a nutshell, our findings may guide patients and surgeons regarding the type of intervention and reconstruction options to be adopted in prospective ...
Source: The American Surgeon - March 21, 2024 Category: Surgery Authors: Mehmet F Sa ğdıç Onur C G üler Orkun Suba şı Özhan Albayrak Cihangir Özaslan Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Surgical outcomes of total duct excision in the diagnosis and management of nipple discharge
CONCLUSIONS: TDE can be considered for the diagnostics and management of nipple discharge. Blood-stained nipple discharge increases the risk of DCIS or malignancy, but the majority of the time TDE reveals benign breast pathology.PMID:38497796 | DOI:10.1308/rcsann.2022.0093 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 18, 2024 Category: Surgery Authors: K Ward G Selvarajah H Al-Omishy M Sait H N Khan K McEvoy S Robertson Source Type: research
Pleomorphic/solid lobular carcinoma of male breast with PALB2 germline mutation: case report and literature review
Pathologica. 2024 Feb;116(1):62-68. doi: 10.32074/1591-951X-936.ABSTRACTMale breast cancer (MBC) accounts for approximately 1% of all breast cancers and among these infiltrating lobular carcinomas (ILC) represents only 1-2% of all MBC cases. Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of ILC with only eight cases reported until now in males. Up to 10% of MBC cases have a germline pathogenic variant in a predisposing gene such as BRCA1 and BRCA2 genes. Mutations in PALB2 (partner and localizer of BRCA2) have been reported in men with breast cancer, with a frequency that ranges from 0.8 to 6.4%, bu...
Source: Pathologica - March 14, 2024 Category: Pathology Authors: Evelina Rogges Tiberio Corati Michelina Amato Domenico Campagna Juliette Farro Simona De Toffol Lucio Fortunato Leopoldo Costarelli Source Type: research
