Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations
Abstract
Molecular mechanisms of lip squamous cell carcinoma (LSCC) and actinic cheilitis (AC) are unclear. We aimed at assessing loss of heterozygosity (LOH) and TP53 and BRAF V600E mutations in these lesions. Formalin-fixed paraffin-embedded (FFPE) samples of 17 LSCC and 16 AC were included, with additional 5 fresh LSCC genotyped for TP53 mutations. LOH was assessed by six polymorphic markers located at 9p22, 9q22, and 17p13 and correlated with cell proliferation (Ki-67) and P53 immunostaining. Direct sequencing of TP53 exons 2–11 (fresh samples), and exons 5–9 (FFPE samples) was carried out. BRAF V...
Source: Tumor Biology - June 18, 2015 Category: Cancer & Oncology Source Type: research
FLiGS Score: A New Method of Outcome Assessment for Lip Carcinoma–Treated Patients
Conclusions: FLiGS score is a simple way of assessing functional impairment related to lip cancer before and after surgery; it is sensitive, valid, reliable, and clinically relevant: it provides useful information to orient the physician in the postoperative management and in the rehabilitation program.
(C) 2015 American Society of Plastic Surgeons (Source: Plastic and Reconstructive Surgery – Global Open)
Source: Plastic and Reconstructive Surgery – Global Open - March 1, 2015 Category: Cosmetic Surgery Tags: 2014 SICPRE Proceedings: Meeting Proceedings Source Type: research
