Podoplanin, ezrin, and Rho-A proteins may have joint participation in tumor invasion of lip cancer

ConclusionsTherefore, our results confirm a correlation among podoplanin, ezrin, and Rho-A expressions in squamous cell carcinoma of the lip suggesting a cooperative participation of these proteins in cell movement and invasion.Clinical relevanceFurthermore, strong cytoplasmic podoplanin expression could be helpful to identify patients with squamous cell carcinoma of the lip and lower risk of loco-regional recurrences.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research