Immunohistochemical expression of DNA methyltransferases 1, 3a, and 3b in actinic cheilitis and lip squamous cell carcinomas
ConclusionsThe results suggested that DNMT 3a could play a key role in the methylation process of initial steps of UV carcinogenesis present in AC while DNMT 3b could be responsible for de novo methylation in already established lip cancer. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - April 30, 2016 Category: Pathology Authors: Filipe I. Daniel, Soraia R. Alves, Daniella S. C. Vieira, Michelle T. Biz, Inah W. B. S. Daniel, Filipe Modolo Tags: Original Article Source Type: research

Variation in Cancer Incidence among Patients with ESRD during Kidney Function and Nonfunction Intervals
Among patients with ESRD, cancer risk is affected by kidney dysfunction and by immunosuppression after transplant. Assessing patterns across periods of dialysis and kidney transplantation may inform cancer etiology. We evaluated 202,195 kidney transplant candidates and recipients from a linkage between the Scientific Registry of Transplant Recipients and cancer registries, and compared incidence in kidney function intervals (time with a transplant) with incidence in nonfunction intervals (waitlist or time after transplant failure), adjusting for demographic factors. Incidence of infection-related and immune-related cancer ...
Source: Journal of the American Society of Nephrology : JASN - April 28, 2016 Category: Urology & Nephrology Authors: Yanik, E. L., Clarke, C. A., Snyder, J. J., Pfeiffer, R. M., Engels, E. A. Tags: Clinical Epidemiology Source Type: research

The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients: a systematic review
Head and neck cancer (HNC) is common in several countries around the world, with an estimated number of 300,400 new cases and 145,400 deaths from oral cavity and lip cancer occurred in 2012 [1]. Oral cavity cancers, as well as larynx and pharynx cancer, represent about 10% of all malignancies in men and 4% in women [2]. Some studies [3,4] show that, unfortunately, many HNC patients are diagnosed when the disease is already at an advanced stage (Stage III/IV) and patients suffer conditions of nutritional vulnerability, with a high risk of malnutrition [5–7]. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - March 14, 2016 Category: Cancer & Oncology Authors: Valentina Bressan, Simone Stevanin, Monica Bianchi, Giuseppe Aleo, Annamaria Bagnasco, Loredana Sasso Source Type: research

Retrospective Outcome Analysis of 39 Patients Who Underwent Lip Surgery for Cutaneous Carcinoma
Conclusion Differences between the surgical margins and the final histologic margins were the main finding of this retrospective study. These differences were attributed to surgical practices and modification during the histological process. Nevertheless, we did not observe a higher rate of recurrence or death in our study than in literature. (Source: Journal of Maxillofacial and Oral Surgery)
Source: Journal of Maxillofacial and Oral Surgery - February 4, 2016 Category: ENT & OMF Source Type: research

Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p > 0.05). Immunoexpression of p53 was higher in SCC than in A...
Source: Archives of Dermatological Research - February 3, 2016 Category: Dermatology Source Type: research

High azathioprine dose and lip cancer risk in liver, heart, and lung transplant recipients: A population-based cohort study
Iatrogenic immunosuppression is a risk factor for lip cancer but the determinants are unknown. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 30, 2016 Category: Dermatology Authors: Renhua Na, Maarit A. Laaksonen, Andrew E. Grulich, Nicola S. Meagher, Geoffrey W. McCaughan, Anne M. Keogh, Claire M. Vajdic Tags: Original article Source Type: research

Lip cancer: a clinicopathological study and treatment outcomes in a 25-year experience
This study aims to investigate the clinicopathological variables profile of a large sample of lip squamous cell carcinoma (LSCC) patients treated in a head and neck cancer reference center for the last 25 years, and to analyze the influence of these variables on the treatment outcomes. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - January 29, 2016 Category: ENT & OMF Authors: Éder Ricardo Biasoli, Vitor Bonetti Valente, Bruna Mantovan, Francisco Urbano Collado, Sebastião Conrado Neto, Maria Lúcia Marçal Mazza Sundefeld, Glauco Issamu Miyahara, Daniel Galera Bernabé Source Type: research

Neglected giant spinocellular carcinoma of the lower lip.
We present a rare variant of giant form of SCC on the lower lip in a 70-year-old patient, which had been neglected for many years, due to social disadvantages and absence of any resources for adequate medical help, until the tumor caused total inability of administration of food and drink. The recent diagnostic and therapeutic options are considered. Despite well-known etiologic factors regarding squamous cell carcinoma and the newest prognostic factors on tumor differentiation, such as β-catenin abnormal expression, the negative influence of the demographic characteristics of the patient were also in focus. Certain outca...
Source: Journal of Biological Regulators and Homeostatic Agents - January 16, 2016 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Reconstruction after resection of a lower lip squamous cell carcinoma with a submental island flap.
We describe our technique for reconstructing the lower lip with a submental island flap. PMID: 26670761 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - December 1, 2015 Category: ENT & OMF Authors: Kim JP, Park HW, Park JJ, Woo SH Tags: Ear Nose Throat J Source Type: research

Conclusion Head and neck tumors are a rare group of clinically and biologically diverse neoplastic diseases. Among the residents of the Chelyabinsk region, men are 2–3 times more susceptible to cancer of the oral cavity and pharynx than women. High mortality rate is due to late referral of patients to specialized clinics; most head and neck cancer patients are diagnosed at advanced stages. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

Dosimetric analysis and clinical outcomes in CT-based mould brachytherapy in early oral cancers in patients unfit for surgery.
CONCLUSIONS: Mould therapy is an effective treatment method for selected early and superficial squamous cell carcinomas of the oral cavity, although indications are limited. PMID: 26034496 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - November 18, 2015 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

CD1a+ and CD83+ Langerhans cells are reduced in lower lip squamous cell carcinoma
ConclusionThese results suggest that depletion of epithelial LCs, but not IDCs in the connective tissue, would represent an important step for lip cancer development. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - November 1, 2015 Category: Pathology Authors: Juliane Oliveira Gomes, Marianne Vasconcelos Carvalho, Felipe Paiva Fonseca, Rogério Oliveira Gondak, Márcio Ajudarte Lopes, Pablo Agustin Vargas Tags: Original Article Source Type: research

Inferiorly based nasolabial flap for reconstruction of the moderate to large defects of lips following cancer resection
Conclusion Simplicity of dissection, robust blood supply, best color match, short procedure time, and minimal donor site morbidity reinforce this flap as a useful adjunct in lip reconstruction. Level of Evidence: IV, therapeutic study. (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - October 26, 2015 Category: Cosmetic Surgery Source Type: research

The pattern of lip cancer occurrence over the 1990–2011 period in public hospitals in Madrid, Spain
ConclusionsThe pattern of lip cancer reported to Public Hospitals of Madrid is changing: declining rates are noted since 2001–02. However, it is necessary to monitor these data to confirm the observed trends in future years. (Source: Journal of Oral Pathology and Medicine)
Source: Journal of Oral Pathology and Medicine - August 1, 2015 Category: Pathology Authors: Adelaida Domínguez‐Gordillo, Germán Esparza‐Gómez, Belén García‐Jiménez, Rocío Cerero‐Lapiedra, Inmaculada Casado‐Gómez, Patricia Romero‐Lastra, Saman Warnakulasuriya Tags: Original Article Source Type: research

Leczenie raka wargi w materiale Kliniki Otolaryngologii i Onkologii Laryngologicznej Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu
Publication date: March–April 2014 Source:Otolaryngologia Polska, Volume 68, Issue 2 Author(s): Henryk Kaźmierczak , Zuzanna Pujanek , Wojciech Kaźmierczak , Jerzy Kochan The subject of this study is methods and results of treatment of 21 cases of lip cancer between 2007 and 2012, which included 15 men and 6 women, aged 48–63. In 18 cases it was squamous cell carcinoma, in other 3 basocellulare carcinoma. Of the hospitalized patients the following clinical stages were found: T1 – five, T2 – five, T3 – seven, T4 – four. We operated with several techniques, we performed: V-incision and surgery according...
Source: Otolaryngologia Polska - June 26, 2015 Category: ENT & OMF Source Type: research