Rates of Hypoglycemia Predicted in Patients with Type 2 Diabetes on Insulin Glargine 300 U/ml Versus First- and Second-Generation Basal Insulin Analogs: The Real-World LIGHTNING Study
ConclusionsBased on real-world data, predicted rates of severe hypoglycemia with Gla-300 tended to be lower versus first-generation BI analogs and similar versus IDeg in a wide spectrum of patients with T2DM.FundingSanofi, Paris, France. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 14, 2019 Category: Endocrinology Source Type: research
Successful management of type IV hypersensitivity reactions to human insulin analogue with injecting mixtures of biphasic insulin aspart and dexamethasone
Publication date: Available online 28 January 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Wei-Lun Wen, Kun-Bow Tsai, Yi-Huei Lin, Shang-Jyh Hwang, Pi-Jung Hsiao, Shyi-Jang Shin, Wei-Wen HungAlthough hypersensitivity reaction to insulin was supposed to be less-frequent with current insulin analogue, case reports with different types of allergic reactions to insulin analogue were still reported. The most common form is type I hypersensitivity reaction with IgE-mediated. Besides, type III (IgG and IgM-mediated) and type IV (T-cell mediated delayed reaction) hypersensitivity reactions were also reported. ...
Source: Journal of the Formosan Medical Association - January 29, 2019 Category: General Medicine Source Type: research
Successful management of type IV hypersensitivity reactions to human insulin analogue with injecting mixtures of biphasic insulin aspart and dexamethasone.
Abstract
Although hypersensitivity reaction to insulin was supposed to be less-frequent with current insulin analogue, case reports with different types of allergic reactions to insulin analogue were still reported. The most common form is type I hypersensitivity reaction with IgE-mediated. Besides, type III (IgG and IgM-mediated) and type IV (T-cell mediated delayed reaction) hypersensitivity reactions were also reported. Here we presented a long-standing type 2 diabetes with insulin requirements with hypersensitivity reactions to insulin actrapid, insulin aspart, insulin glargine, insulin detemir, and bi...
Source: J Formos Med Assoc - January 28, 2019 Category: General Medicine Authors: Wen WL, Tsai KB, Lin YH, Hwang SJ, Hsiao PJ, Shin SJ, Hung WW Tags: J Formos Med Assoc Source Type: research
Lilly Insulin Glargine Versus Lantus ® in Insulin-Naïve and Insulin-Treated Adults with Type 2 Diabetes: A Randomized, Controlled Trial (ELEMENT 5)
ConclusionOverall, LY IGlar and IGlar combined with OAMs provided similar glucose control and safety findings in this T2D population, which included a greater proportion of Asian patients and had broader background basal insulin experience than a previously studied T2D population.Trial RegistrationClinicalTrials.gov identifier, NCT02302716.FundingEli Lilly and Company and Boehringer Ingelheim.Plain Language SummaryPlain language summary available for this article. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 2, 2019 Category: Endocrinology Source Type: research
A Significant Injury with Just a Speck of Pain
BY ARJUN BHARADWAJ & KHALID MALIK, MDA 58-year-old man who lived at a nursing facility came to the emergency department complaining of abdominal pain for three days. His pain was localized to the epigastrium and periumbilical regions. The nursing home staff indicated that he was hypotensive and possibly hypoxic.The patient said he never had similar pain before, which he said pain was mild and constant in severity and did not radiate to the chest, back, pelvis, or shoulders. He also reported nausea but no trauma, falls, vomiting, fever, chills, dizziness, chest pain, shortness of breath, trouble walking, or change in...
Source: The Case Files - October 16, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
A 26-week, randomized trial of insulin detemir versus NPH insulin in children and adolescents with type 2 diabetes (iDEAt2)
Conclusion: No safety issues were revealed with either basal insulin. Due to the low number of patients recruited, no efficacy conclusions could be drawn.ClinicalTrials.govidentifier: NCT02131272.What is known:• There is a growing worldwide epidemic of type 2 diabetes in children and adolescents.• There is a lack of research and limited treatment options currently available in this population.What is new:• No safety issues with insulin detemir or neutral protamine Hagedorn insulin in children and adolescents with type 2 diabetes were observed.• Improving clinical trial recruitment, along with providing early, effic...
Source: European Journal of Pediatrics - October 1, 2018 Category: Pediatrics Source Type: research
Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection Versus Insulin Alone in Type 2 Diabetes.
Conclusions: These observations argue against large effects of GLP-1 agonists on myocardial fuel metabolism as mediators of beneficial treatment effects on myocardial function and ischemia protection.
PMID: 30020461 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 17, 2018 Category: Endocrinology Authors: Mather KJ, Considine RV, Hamilton L, Patel NA, Mathias C, Territo W, Goodwill A, Tune JD, Green MA, Hutchins GD Tags: J Clin Endocrinol Metab Source Type: research
A 26-week, randomized trial of insulin detemir versus NPH insulin in children and adolescents with type 2 diabetes (iDEAt2)
Conclusion: No safety issues were revealed with either basal insulin. Due to the low number of patients recruited, no efficacy conclusions could be drawn.ClinicalTrials.govidentifier: NCT02131272.What is known:• There is a growing worldwide epidemic of type 2 diabetes in children and adolescents.• There is a lack of research and limited treatment options currently available in this population.What is new:• No safety issues with insulin detemir or neutral protamine Hagedorn insulin in children and adolescents with type 2 diabetes were observed.• Improving clinical trial recruitment, along with providing early, effic...
Source: European Journal of Pediatrics - July 16, 2018 Category: Pediatrics Source Type: research
Costs associated with long-acting insulin analogues in patients with diabetes.
CONCLUSIONS: Despite higher drug costs, the real-world overall medical costs of LAIAs are not significantly different from those of NPH in patients with diabetes. The findings may be helpful for formulary decision making for patients with diabetes in a cost-constrained environment.
PMID: 30020738 [PubMed - in process] (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - July 1, 2018 Category: Health Management Authors: Alemayehu B, Speiser J, Bloudek L, Sarnes E Tags: Am J Manag Care Source Type: research
Evaluating the cost-effectiveness of insulin detemir versus neutral protamine Hagedorn insulin in patients with type 1 or type 2 diabetes in the UK using a short-term modeling approach
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - May 16, 2018 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Identification of N-Terminally Truncated Derivatives of Insulin Analogs Formed in Pharmaceutical Formulations
ConclusionsThe following derivatives formed by truncation of the B chain in insulin analogs were identified in pharmaceutical formulations: desPheB1-N-formyl-ValB2 derivative, desPheB1 derivative, pyroGluB4 derivative. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - May 16, 2018 Category: Drugs & Pharmacology Source Type: research
Glycemic Control in Adult Type 1 Diabetes Patients with Insulin Glargine, Insulin Detemir, or Continuous Subcutaneous Insulin Infusion in Daily Practice
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology and Therapeutics)
Source: Diabetes Technology and Therapeutics - May 9, 2018 Category: Endocrinology Authors: P äivi Rautiainen Hilkka Tirkkonen Tiina Laatikainen Source Type: research
Glycemic Control in Adult Type 1 Diabetes Patients with Insulin Glargine, Insulin Detemir, or Continuous Subcutaneous Insulin Infusion in Daily Practice
Diabetes Technology&Therapeutics, Ahead of Print. (Source: Diabetes Technology)
Source: Diabetes Technology - May 9, 2018 Category: Endocrinology Authors: P äivi Rautiainen Hilkka Tirkkonen Tiina Laatikainen Source Type: research
GSE37785 Differential metabolic effects of insulin detemir versus NPH in patients with type 2 diabetes
Contributors : Ben Sheldon ; Margot Umpleby ; Emmanuelle Meugnier ; Sandra Pesenti ; Hubert VidalSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe investigate whether lower weight gain with insulin detemir is due to a decrease in energy intake or an increase in energy output and whether any change in energy balance is accompanied by changes in hormones, lipid metabolism and muscle gene expression. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 20, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Parenteral nutrition and insulin per protocol improve diabetes management after total pancreatectomy.
CONCLUSIONS: After total pancreatectomy, PN with insulin treatment per protocol improves glycaemic control compared with glucose infusion and reduces the number of non-infectious post-operative complications without increasing hypoglycaemia.
FUNDING: none.
TRIAL REGISTRATION: not relevant.
PMID: 29619926 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research
