Comparison of Insulin Glargine and Detemir Effects on Hormones of Appetite and Metabolic ...
The aim of this study was to compare the insulin glargine and detemir effects on hormons affecting appetite and metabolic control of patients with type 1 diabetes. This single-blind randomized clinical trial was conducted on patients aged 2 to 18 years with type 1 diabetes who were referred to the endocrinology department of Ali-Asghar Children Hospital in Tehran, from April to September 2019. Patients were randomly allocated to receive insulin Glargine or insulin Detemir. Before starting treatment, blood samples were obtained for routine biochemical tests and factors affecting appetite, including Leptin, Ghrelin, Aguti-Re...
Source: Iranian Journal of Pharmaceutical Research - August 31, 2021 Category: Drugs & Pharmacology Source Type: research
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir
In conclusion, pig breed and injection region affected the PK of liraglutide, insulin aspart and insulin detemir and reliable predictions of human PK were demonstrated when applying single-species allometric scaling with the pig as a pre-clinical animal model.PMID:34428585 | DOI:10.1016/j.trsl.2021.08.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 24, 2021 Category: Laboratory Medicine Authors: Karen-Margrethe Pedersen Anna Katrina J ógvansdóttir Gradel Trine Pagh Ludvigsen Berit Østergaard Christoffersen Caroline Amalie Fuglsang-Damgaard Kristian Moss Bendtsen Suzi H øgh Madsen Valentina Manf é Hanne Hoffman Fr ølund Refsgaard Source Type: research
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir
In conclusion, pig breed and injection region affected the PK of liraglutide, insulin aspart and insulin detemir and reliable predictions of human PK were demonstrated when applying single-species allometric scaling with the pig as a pre-clinical animal model.PMID:34428585 | DOI:10.1016/j.trsl.2021.08.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 24, 2021 Category: Laboratory Medicine Authors: Karen-Margrethe Pedersen Anna Katrina J ógvansdóttir Gradel Trine Pagh Ludvigsen Berit Østergaard Christoffersen Caroline Amalie Fuglsang-Damgaard Kristian Moss Bendtsen Suzi H øgh Madsen Valentina Manf é Hanne Hoffman Fr ølund Refsgaard Source Type: research
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir
In conclusion, pig breed and injection region affected the PK of liraglutide, insulin aspart and insulin detemir and reliable predictions of human PK were demonstrated when applying single-species allometric scaling with the pig as a pre-clinical animal model.PMID:34428585 | DOI:10.1016/j.trsl.2021.08.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - August 24, 2021 Category: Laboratory Medicine Authors: Karen-Margrethe Pedersen Anna Katrina J ógvansdóttir Gradel Trine Pagh Ludvigsen Berit Østergaard Christoffersen Caroline Amalie Fuglsang-Damgaard Kristian Moss Bendtsen Suzi H øgh Madsen Valentina Manf é Hanne Hoffman Fr ølund Refsgaard Source Type: research
Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir
Prediction of human pharmacokinetics (PK) from data obtained in animal studies is essential in drug development. Here, we present a thorough examination of how to achieve good pharmacokinetic data from the pig model for translational purposes by using single-species allometric scaling for selected therapeutic proteins: liraglutide, insulin aspart and insulin detemir. The predictions were based on non-compartmental analysis of intravenous and subcutaneous PK data obtained from two injection regions (neck, thigh) in two pig breeds, domestic pig and G öttingen Minipig, that were compared with PK parameters reported in humans...
Source: Translational Research - August 20, 2021 Category: Research Authors: Karen-Margrethe Pedersen, Anna Katrina J ógvansdóttir Gradel, Trine Pagh Ludvigsen, Berit Østergaard Christoffersen, Caroline Amalie Fuglsang-Damgaard, Kristian Moss Bendtsen, Suzi Høgh Madsen, Valentina Manfé, Hanne Hoffman Frølund Refsgaard Source Type: research
Practical guidance on the initiation, titration, and switching of basal insulins: a narrative review for primary care
Ann Med. 2021 Dec;53(1):998-1009. doi: 10.1080/07853890.2021.1925148.ABSTRACTMany patients with type 2 diabetes will ultimately require the inclusion of basal insulin in their treatment regimen. Since most people with type 2 diabetes are managed in the community, it is important that primary care providers understand and correctly manage the initiation and titration of basal insulins, and help patients to self-manage insulin injections. Newer, long-acting basal insulins provide greater stability and flexibility than older preparations and improved delivery systems. Basal insulin is usually initiated at a conservative dose ...
Source: Annals of Medicine - June 24, 2021 Category: Internal Medicine Authors: Roopa Mehta Ronald Goldenberg Daniel Katselnik Louis Kuritzky Source Type: research
Detemir versus Neutral Protamine Hagedorn Insulin for Diabetes Mellitus in Pregnancy: A Comparative-Effectiveness, Randomized Controlled Trial
Insulin detemir, being used increasingly during pregnancy, may have pharmacological benefits compared to neutral protamine Hagedorn (NPH). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 14, 2021 Category: OBGYN Authors: Michal Fishel Bartal, Clara Ward, Sean C. Blackwell, Joycelyn A. Ashby Cornthwaite, Caroline Zhang, Jerrie S. Refuerzo, Claudia Pedroza, Kyung Hyun LEE, Suneet P. Chauhan, Baha M. SIBAI Tags: Original Research: Obstetrics Source Type: research
Detemir vs neutral protamine Hagedorn insulin for diabetes mellitus in pregnancy: a comparative effectiveness, randomized controlled trial
Insulin detemir, being used increasingly during pregnancy, may have pharmacologic benefits compared with neutral protamine Hagedorn. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - April 14, 2021 Category: OBGYN Authors: Michal Fishel Bartal, Clara Ward, Sean C. Blackwell, Joycelyn A. Ashby Cornthwaite, Caroline Zhang, Jerrie S. Refuerzo, Claudia Pedroza, Kyung Hyun Lee, Suneet P. Chauhan, Baha M. Sibai Tags: SMFM Papers Source Type: research
All-Cause and Cardiovascular Mortality Among Insulin-Na ïve People With Type 2 Diabetes Treated With Insulin Detemir or Glargine: A Cohort Study in the UK
ConclusionIn this real-world observational study, there was an association between all-cause mortality and basal insulin choice in insulin-na ïve people with T2D; the mortality risk was lower with detemir versus glargine after adjustment for potential confounders. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 15, 2021 Category: Endocrinology Source Type: research
(Ultra-)long-acting insulin analogues for people with type 1 diabetes mellitus
CONCLUSIONS: Comparing insulin detemir with NPH insulin for T1DM showed lower risk of severe hypoglycaemia in favour of insulin detemir (moderate-certainty evidence). However, the 95% prediction interval indicated inconsistency in this finding. Both insulin detemir and insulin glargine compared with NPH insulin did not show benefits or harms for severe nocturnal hypoglycaemia. For all other main outcomes with overall low risk of bias and comparing insulin analogues with each other, there was no true beneficial or harmful effect for any intervention. Data on patient-important outcomes such as QoL, macrovascular and microvas...
Source: Cochrane Database of Systematic Reviews - March 4, 2021 Category: General Medicine Authors: Bianca Hemmingsen Maria-Inti Metzendorf Bernd Richter Source Type: research
Disproportionality analysis of spontaneously reported hypoglycemia events due to insulin use: A comparison between insulin detemir and insulin degludec using the Korea Adverse Event Reporting System.
CONCLUSION: When we compared the proportionality of hypoglycemic events among the total number of reported AEs for each of the two basal insulins through disproportionality analysis using the spontaneous ADR reporting system, IDeg showed a relatively lower rate of reported hypoglycemic events than IDet.
PMID: 33191903 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
(Ultra-)long-acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus.
CONCLUSIONS: While the effects on HbA1c were comparable, treatment with insulin glargine and insulin detemir resulted in fewer participants experiencing hypoglycaemia when compared with NPH insulin. Treatment with insulin detemir also reduced the incidence of serious hypoglycaemia. However, serious hypoglycaemic events were rare and the absolute risk reducing effect was low. Approximately one in 100 people treated with insulin detemir instead of NPH insulin benefited. In the studies, low blood glucose and HbA1c targets, corresponding to near normal or even non-diabetic blood glucose levels, were set. Therefore, results fro...
Source: Cochrane Database of Systematic Reviews - November 9, 2020 Category: General Medicine Authors: Semlitsch T, Engler J, Siebenhofer A, Jeitler K, Berghold A, Horvath K Tags: Cochrane Database Syst Rev Source Type: research
Similar cardiovascular outcomes between insulin detemir and insulin glargine in type 2 diabetic patients with extremely atherosclerotic cardiovascular disease risks
Endocrine Practice,Volume 26, Issue 8, Page 818-829, August 2020. (Source: Endocrine Practice)
Source: Endocrine Practice - September 2, 2020 Category: Endocrinology Authors: Tien-Hsing Chen Chih-Ching Wang Chi-Hung Liu Ching-Chung Hsiao Szu-Tah Chen Feng-Hsuan Liu Ming-Yun Ho Yan-Rong Li Source Type: research
