Optimization of pig models for translation of subcutaneous pharmacokinetics of therapeutic proteins: Liraglutide, insulin aspart and insulin detemir
In conclusion, pig breed and injection region affected the PK of liraglutide, insulin aspart and insulin detemir and reliable predictions of human PK were demonstrated when applying single-species allometric scaling with the pig as a pre-clinical animal model.PMID:34428585 | DOI:10.1016/j.trsl.2021.08.005
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Karen-Margrethe Pedersen Anna Katrina J ógvansdóttir Gradel Trine Pagh Ludvigsen Berit Østergaard Christoffersen Caroline Amalie Fuglsang-Damgaard Kristian Moss Bendtsen Suzi H øgh Madsen Valentina Manf é Hanne Hoffman Fr ølund Refsgaard Source Type: research