Safety and efficacy of insulin detemir versus neutral protamine Hagedorn in the treatment of diabetes during pregnancy: systematic review and meta-analysis of randomized controlled trials
To compare the safety and efficacy of insulin detemir versus neutral protamine Hagedorn (NPH) in pregnant women with diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2022 Category: Endocrinology Authors: Kleoniki I. Athanasiadou, Stavroula A. Paschou, Theodosios Stamatopoulos, Evgenia Papakonstantinou, Anna-Bettina Haidich, Dimitrios G. Goulis Source Type: research
Safety and efficacy of insulin detemir versus NPH in the treatment of diabetes during pregnancy: Systematic review and meta-analysis of randomized controlled trials
To compare the safety and efficacy of insulin detemir versus neutral protamine Hagedorn (NPH) in pregnant women with diabetes. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - July 21, 2022 Category: Endocrinology Authors: Kleoniki I. Athanasiadou, Stavroula A. Paschou, Theodosios Stamatopoulos, Evgenia Papakonstantinou, Anna-Bettina Haidich, Dimitrios G. Goulis Source Type: research
Twenty Years of Insulin Gla-100: A Systematic Evaluation of Its Efficacy and Safety in Type 2 Diabetes Mellitus
ConclusionsThe evidence presented in this review suggests that Gla-100 is an effective option for both insulin initiation and intensification strategies used in the management of T2DM. (Source: Diabetes Therapy)
Source: Diabetes Therapy - June 30, 2022 Category: Endocrinology Source Type: research
Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis
CONCLUSIONS: It was found that there is no clinically considerable difference between the impacts of insulin detemir and insulin glargine in diabetic patients. The only statistically significant differences were less weight gain in type 2 diabetes and fewer episodes of severe hypoglycemia in type 1 diabetes with insulin detemir.PMID:35579011 | DOI:10.1080/17512433.2022.2078700 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - May 17, 2022 Category: Drugs & Pharmacology Authors: Soheila Rezaei Ali Taheri Saeed Taheri Sara Kasizadeh Behzad Fatemi Mende M Sorato Source Type: research
Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis
CONCLUSIONS: It was found that there is no clinically considerable difference between the impacts of insulin detemir and insulin glargine in diabetic patients. The only statistically significant differences were less weight gain in type 2 diabetes and fewer episodes of severe hypoglycemia in type 1 diabetes with insulin detemir.PMID:35579011 | DOI:10.1080/17512433.2022.2078700 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 17, 2022 Category: Drugs & Pharmacology Authors: Soheila Rezaei Ali Taheri Saeed Taheri Sara Kasizadeh Behzad Fatemi Mende M Sorato Source Type: research
Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis
CONCLUSIONS: It was found that there is no clinically considerable difference between the impacts of insulin detemir and insulin glargine in diabetic patients. The only statistically significant differences were less weight gain in type 2 diabetes and fewer episodes of severe hypoglycemia in type 1 diabetes with insulin detemir.PMID:35579011 | DOI:10.1080/17512433.2022.2078700 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - May 17, 2022 Category: Drugs & Pharmacology Authors: Soheila Rezaei Ali Taheri Saeed Taheri Sara Kasizadeh Behzad Fatemi Mende M Sorato Source Type: research
Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis
CONCLUSIONS: It was found that there is no clinically considerable difference between the impacts of insulin detemir and insulin glargine in diabetic patients. The only statistically significant differences were less weight gain in type 2 diabetes and fewer episodes of severe hypoglycemia in type 1 diabetes with insulin detemir.PMID:35579011 | DOI:10.1080/17512433.2022.2078700 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 17, 2022 Category: Drugs & Pharmacology Authors: Soheila Rezaei Ali Taheri Saeed Taheri Sara Kasizadeh Behzad Fatemi Mende M Sorato Source Type: research
Efficacy and safety of insulin detemir versus glargine in patients with diabetes: a systematic review and meta-analysis
CONCLUSIONS: It was found that there is no clinically considerable difference between the impacts of insulin detemir and insulin glargine in diabetic patients. The only statistically significant differences were less weight gain in type 2 diabetes and fewer episodes of severe hypoglycemia in type 1 diabetes with insulin detemir.PMID:35579011 | DOI:10.1080/17512433.2022.2078700 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - May 17, 2022 Category: Drugs & Pharmacology Authors: Soheila Rezaei Ali Taheri Saeed Taheri Sara Kasizadeh Behzad Fatemi Mende M Sorato Source Type: research
Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia
Biophys Chem. 2022 Mar 28;285:106809. doi: 10.1016/j.bpc.2022.106809. Online ahead of print.ABSTRACTInsulin detemir (IDt) is long-acting insulin whose protraction mechanism is based on a covalently attached fatty acid to an insulin molecule. Utilizing the high affinity of fatty acids towards human serum albumin (HA), the modified detemir molecule binds with good affinity to HA, which functions as a reservoir that leads to a slow and prolonged release of insulin. However, questions were raised over potential interactions between other drugs and IDt through competitive binding on the binding site(s) of HA. In a previous stud...
Source: Biophysical Chemistry - April 3, 2022 Category: Chemistry Authors: Imad I Hamdan Dua'a G H Farah Enam A Khalil Randa S H Mansour Heba Abdel-Halim Source Type: research
Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia
Biophys Chem. 2022 Mar 28;285:106809. doi: 10.1016/j.bpc.2022.106809. Online ahead of print.ABSTRACTInsulin detemir (IDt) is long-acting insulin whose protraction mechanism is based on a covalently attached fatty acid to an insulin molecule. Utilizing the high affinity of fatty acids towards human serum albumin (HA), the modified detemir molecule binds with good affinity to HA, which functions as a reservoir that leads to a slow and prolonged release of insulin. However, questions were raised over potential interactions between other drugs and IDt through competitive binding on the binding site(s) of HA. In a previous stud...
Source: Biophysical Chemistry - April 3, 2022 Category: Chemistry Authors: Imad I Hamdan Dua'a G H Farah Enam A Khalil Randa S H Mansour Heba Abdel-Halim Source Type: research
Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia
Biophys Chem. 2022 Mar 28;285:106809. doi: 10.1016/j.bpc.2022.106809. Online ahead of print.ABSTRACTInsulin detemir (IDt) is long-acting insulin whose protraction mechanism is based on a covalently attached fatty acid to an insulin molecule. Utilizing the high affinity of fatty acids towards human serum albumin (HA), the modified detemir molecule binds with good affinity to HA, which functions as a reservoir that leads to a slow and prolonged release of insulin. However, questions were raised over potential interactions between other drugs and IDt through competitive binding on the binding site(s) of HA. In a previous stud...
Source: Biophysical Chemistry - April 3, 2022 Category: Chemistry Authors: Imad I Hamdan Dua'a G H Farah Enam A Khalil Randa S H Mansour Heba Abdel-Halim Source Type: research
Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia
Biophys Chem. 2022 Mar 28;285:106809. doi: 10.1016/j.bpc.2022.106809. Online ahead of print.ABSTRACTInsulin detemir (IDt) is long-acting insulin whose protraction mechanism is based on a covalently attached fatty acid to an insulin molecule. Utilizing the high affinity of fatty acids towards human serum albumin (HA), the modified detemir molecule binds with good affinity to HA, which functions as a reservoir that leads to a slow and prolonged release of insulin. However, questions were raised over potential interactions between other drugs and IDt through competitive binding on the binding site(s) of HA. In a previous stud...
Source: Biophysical Chemistry - April 3, 2022 Category: Chemistry Authors: Imad I Hamdan Dua'a G H Farah Enam A Khalil Randa S H Mansour Heba Abdel-Halim Source Type: research
Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia
Biophys Chem. 2022 Mar 28;285:106809. doi: 10.1016/j.bpc.2022.106809. Online ahead of print.ABSTRACTInsulin detemir (IDt) is long-acting insulin whose protraction mechanism is based on a covalently attached fatty acid to an insulin molecule. Utilizing the high affinity of fatty acids towards human serum albumin (HA), the modified detemir molecule binds with good affinity to HA, which functions as a reservoir that leads to a slow and prolonged release of insulin. However, questions were raised over potential interactions between other drugs and IDt through competitive binding on the binding site(s) of HA. In a previous stud...
Source: Biophysical Chemistry - April 3, 2022 Category: Chemistry Authors: Imad I Hamdan Dua'a G H Farah Enam A Khalil Randa S H Mansour Heba Abdel-Halim Source Type: research
