Insulin detemir vs Neutral Protamine Hagedorn in pregnancy
We read an article by Bartal et al1 with interest, which compared insulin detemir with Neutral Protamine Hagedorn (NPH) during pregnancy for maternal and neonatal outcomes in women with preexisting type 2 diabetes mellitus (T2DM) or overt diabetes mellitus. The authors concluded that detemir resulted in lower rates of adverse ev ents. However, before we believe in that statement, specific unanswered questions need to be addressed. First, the authors mentioned that baseline characteristics were similar between the groups. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 17, 2021 Category: OBGYN Authors: Shalini V. Singh, Nutan, K Aparna Sharma, Yashdeep Gupta Tags: Letter to the Editors Source Type: research
Insulin Detemir vs NPH in Pregnancy
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 17, 2021 Category: OBGYN Authors: Shalini V. Singh, Nutan, K Aparna Sharma, Yashdeep Gupta Tags: Letter to the Editors Source Type: research
Insulin Detemir vs NPH in Pregnancy, a response
(Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 17, 2021 Category: OBGYN Authors: Michal Fishel Bartal, Suneet P. Chauhan, Baha M. Sibai Source Type: research
Insulin Detemir vs Neutral Protamine Hagedorn in Pregnancy: a reply
We thank Dr Singh and colleagues for their insightful comments regarding “Detemir vs Neutral Protamine Hagedorn insulin for diabetes mellitus in pregnancy: a comparative effectiveness, randomized controlled trial.” (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - December 17, 2021 Category: OBGYN Authors: Michal Fishel Bartal, Suneet P. Chauhan, Baha M. Sibai Tags: Letter to the Editors Source Type: research
Comparison of Insulin Glargine and Detemir Effects on Hormones of Appetite and Metabolic Control in Patients with Type 1 Diabetes: A Randomized Clinical Trial
The aim of this study was to compare the insulin glargine and detemir effects on hormons affecting appetite and metabolic control of patients with type 1 diabetes. This single-blind randomized clinical trial was conducted on patients aged 2 to 18 years with type 1 diabetes who were referred to the endocrinology department of Ali-Asghar Children Hospital in Tehran, from April to September 2019. Patients were randomly allocated to receive insulin Glargine or insulin Detemir. Before starting treatment, blood samples were obtained for routine biochemical tests and factors affecting appetite, including Leptin, Ghrelin, Aguti-Re...
Source: Iranian Journal of Pharmaceutical Research - November 16, 2021 Category: Drugs & Pharmacology Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Individual Case Safety Reports Analysis for Patients with Diabetes Mellitus on Insulin in Africa and the Middle East
CONCLUSION: ICSRs features were region-specific and dependent on patient age, gender, report sources, reporter types, suspect products, and AE preferred terms.PMID:34749625 | DOI:10.2174/1574886316666211108103301 (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2021 Category: Drugs & Pharmacology Authors: Charity R N Mlotshwa Johanita R Burger Martine Vorster Dorcas M Rakumakoe Marike Cockeran Source Type: research
Intranasal insulin for treatment of delirium in older hospitalised patients: study protocol for a randomised controlled trial
Introduction
Delirium is one of the most common conditions diagnosed in hospitalised older people and is associated with numerous adverse outcomes, yet there are no proven pharmacological treatments. Recent research has identified cerebral glucose hypometabolism as a pathophysiological mechanism offering a therapeutic target in delirium. Insulin, delivered via the intranasal route, acts directly on the central nervous system and has been shown to enhance cerebral metabolism and improve cognition in patients with mild cognitive impairment and dementia. This trial will determine whether intranasal insulin can reduce the dura...
Source: BMJ Open - October 19, 2021 Category: General Medicine Authors: Nitchingham, A., Milne, A., Toson, B., Tuch, B., Agar, M., Close, J., Caplan, G. Tags: Open access, Geriatric medicine Source Type: research
Synthetic long-acting insulin analogs for the management of type 1 diabetes: an update
Expert Opin Pharmacother. 2021 Sep 1:1-9. doi: 10.1080/14656566.2021.1970136. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes is characterized by insulin deficiency and requires near-physiological insulin replacement. In most patients, this is accomplished by basal bolus therapy consisting of a long-acting basal insulin administered once or twice daily and short-acting insulin with main meals. Several long-acting insulin analogs have been developed to optimize basal insulin therapy.AREAS COVERED: This paper reviews the design of - and data from - randomized controlled trials (RCTs) to assess glucose lowering ef...
Source: Expert Opinion on Pharmacotherapy - September 1, 2021 Category: Drugs & Pharmacology Authors: Ulrik Pedersen-Bjergaard Therese W Fabricius Birger Thorsteinsson Source Type: research
