Copyright
Elsevier (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - July 4, 2019 Category: Veterinary Research Source Type: research

Contributors
THOMAS J. DIVERS, DVM (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - July 4, 2019 Category: Veterinary Research Source Type: research

Contents
Robert J. MacKay (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - July 4, 2019 Category: Veterinary Research Source Type: research

Forthcoming Issues
Diseases of Donkeys and Mules (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - July 4, 2019 Category: Veterinary Research Source Type: research

And Now for Something Completely Different: Some Controversies in Equine Medicine, Surgery, and Reproduction
It has been an honor and privilege to be able to recruit distinguished authors from among multiple disciplines to contribute to this issue and to superintend their manuscripts through to publication. The process has been an unusual challenge as this issue is not primarily a series of state-of-the-art reviews, as is the usual custom. Rather, with the help and advice of consulting editor, Tom Divers, I have for each article selected an element of a topic that is controversial, not universally agreed upon, or otherwise unclear. (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - July 4, 2019 Category: Veterinary Research Authors: Robert J. MacKay Tags: Preface Source Type: research

Update on Surgical Treatment of Wobblers
Cervical vertebral compressive myelopathy (CVCM) represents the most significant disease of the spinal cord in horses for which surgical treatment is described. Current surgical methods used include ventral interbody fusion with kerf cut cylinders and dorsal laminectomy. Polyaxial pedicle screw and rod constructs and ventral locking compression plating have been introduced in the treatment of equine CVCM and present promising alternative approaches to achieve ventral interbody fusion. Advancements in diagnostic imaging and endoscopy of the cervical vertebral canal may improve reliable preoperative identification of the exa...
Source: Veterinary Clinics of North America: Equine Practice - May 26, 2019 Category: Veterinary Research Authors: Lynn Pezzanite, Jeremiah Easley Source Type: research

Are There Shared Mechanisms in the Pathophysiology of Different Clinical Forms of Laminitis and What Are the Implications for Prevention and Treatment?
Laminitis is a consequence of primary disease processes elsewhere in the body. The key pathophysiologic events are insulin dysregulation in endocrinopathic laminitis, ischemia in supporting limb laminitis, and inflammation in sepsis-related laminitis. These apparently disparate mechanisms converge to cause lamellar attachment failure through epithelial cell adhesion loss and stretch, possibly mediated by common growth factor signaling pathways. Tissue damage through mechanical distraction, inflammation, pain, and a proliferative epithelial healing response are features of acute laminitis regardless of the cause. Preventive...
Source: Veterinary Clinics of North America: Equine Practice - May 20, 2019 Category: Veterinary Research Authors: Andrew W. van Eps, Teresa A. Burns Source Type: research

The Equine Sarcoid
This article discusses the main treatments for sarcoid and the specific difficulties of these. It explains to some extent why the frustrations of a condition for which there is no single treatment option have led to the burgeoning of an industry of irrational treatments. The factors that need to be considered before selecting an option for treatment are wider than is the case in most other disease entities as a result of the complexity of the condition, its variable phenotypes, and the individual perceptions and experiences of both veterinarians and owners. (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - May 12, 2019 Category: Veterinary Research Authors: Derek C. Knottenbelt Source Type: research

Equine Neonatal Encephalopathy
Neonatal encephalopathy (NE) and neonatal maladjustment syndrome (NMS) are terms used for newborn foals that develop noninfectious neurologic signs in the immediate postpartum period. Cerebral ischemia, hypoxia, and inflammation leading to neuronal and glial dysfunction and excitotoxicity are considered key mechanisms behind NE/NMS. Attention has been placed on endocrine and paracrine factors that alter brain cell function. Abnormal steroid concentrations (progestogens, neurosteroids) have been measured in critically ill and NE foals. In addition to supportive treatment, antimicrobials should be considered. Controversies r...
Source: Veterinary Clinics of North America: Equine Practice - May 10, 2019 Category: Veterinary Research Authors: Ramiro E. Toribio Source Type: research

What Do We Know About Hepatitis Viruses in Horses?
Theiler disease (serum hepatitis or idiopathic acute hepatic necrosis) has long been suspected to have a viral etiology. Four viruses have been described in association with hepatitis in horses. Further investigation suggests equine pegivirus and Theiler disease –associated virus (a second pegivirus) are neither hepatotropic nor pathogenic. Nonprimate hepacivirus (NPHV) causes subclinical disease in experimental models and has been associated with hepatitis in some clinical cases. Equine parvovirus-hepatitis (EqPV-H) experimentally causes subclinical-to-c linical liver disease and is found in the vast majority of Theiler...
Source: Veterinary Clinics of North America: Equine Practice - May 9, 2019 Category: Veterinary Research Authors: Joy E. Tomlinson, Gerlinde R. Van de Walle, Thomas J. Divers Source Type: research

Exercise-induced Pulmonary Hemorrhage
Exercise-induced pulmonary hemorrhage (EIPH) occurs commonly in horses undergoing strenuous exercise. Reported risk factors include racing in cold temperatures and wearing of bar shoes. In horses with documented moderate to severe EIPH, increasing the interval between races and adopting a negative race pace strategy may reduce the severity of EIPH in subsequent races. EIPH seems to have an impact on performance only when moderate to severe. This occurs in a small number of starters, approximately 6%. EIPH often is erratic in severity from race to race, although across a population it is weakly progressive over increasing r...
Source: Veterinary Clinics of North America: Equine Practice - May 9, 2019 Category: Veterinary Research Authors: Eleanor J. Crispe, Guy D. Lester Source Type: research

Is There Still a Place for Lidocaine in the (Postoperative) Management of Colics?
Intravenous lidocaine is widely used to prevent or treat postoperative ileus in horses. Clinical studies that support this approach are flawed and contradicted by others. Also, physical obstruction could be more important in causing postoperative reflux than postoperative ileus in the horse. The antiinflammatory properties of lidocaine and the role of inflammation from intestinal handling in the genesis of postoperative reflux are questionable. Because of cost and questionable efficacy of lidocaine, a well-designed clinical trial is required to support its continued use. However, lidocaine could be given to provide or enha...
Source: Veterinary Clinics of North America: Equine Practice - May 6, 2019 Category: Veterinary Research Authors: David E. Freeman Source Type: research

Diagnostic Testing for Equine Endocrine Diseases
Despite there being only 2 common endocrine diseases in horses, pituitary pars intermedia dysfunction (PPID) and equine metabolic syndrome (EMS), diagnosis is still confusing. Failing to consider horse factors and treating based on laboratory results only have caused many animals to receive lifelong drug treatment unnecessarily. Increased plasma ACTH, baseline or TRH stimulated, supports a diagnosis of PPID; however, breed, age, thriftiness, illness, coat color, geography, diet, and season also affect ACTH concentration. Insulin dysregulation, the hallmark of EMS, can result from insulin resistance or excessive postprandia...
Source: Veterinary Clinics of North America: Equine Practice - May 6, 2019 Category: Veterinary Research Authors: Dianne McFarlane Source Type: research

Is Electrical Nerve Stimulation the Answer for Management of Equine Headshaking?
Horses with trigeminal mediated headshaking (TMHS) have a decreased activation threshold of the trigeminal nerve and clinical signs are suspected to be a manifestation of trigeminal neuralgia. Electrical nerve stimulation (ENS) is used for management of neuralgia in humans and appears to work via gate control theory. Use of an equine specific percutaneous ENS program in over 130 TMHS horses has resulted in approximately 50% success return to previous work. Electroacupuncture may also be useful in the management TMHS. Optimization of ENS procedures for TMHS is likely to require a greater understanding of the etiopathogenesi...
Source: Veterinary Clinics of North America: Equine Practice - April 28, 2019 Category: Veterinary Research Authors: Kirstie Pickles Source Type: research

Clinical Cardiology
VETERINARY CLINICS OF NORTH AMERICA: EQUINE PRACTICE (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - March 21, 2019 Category: Veterinary Research Authors: Colin C. Schwarzwald, Katharyn J. Mitchell Source Type: research