Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity
Toxicol Pathol. 2023 Nov 20:1926233231212255. doi: 10.1177/01926233231212255. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acute liver failure. One mechanism of DILI is altered bile acid homeostasis and involves several hepatic bile acid transporters. Functional impairment of some hepatic bile acid transporters by drugs, disease, or genetic mutations may lead to toxic accumulation of bile acids within hepatocytes and increase DILI susceptibility. This review focuses on the role of hepatic bile ...
Source: Toxicologic Pathology - November 20, 2023 Category: Pathology Authors: Chitra Saran Kim L R Brouwer Source Type: research
