Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Next-Generation Sequencing-Based Identification of < em > Enterobacter hormaechei < /em > as Causative Agent of High Mortality Disease in NOD.Cg- < em > Prkdc < sup > scid < /sup > < /em > < em > Il2rg < sup > tm1Wjl < /sup > < /em > /SzJ (NSG) Mice
We describe a high mortality disease outbreak caused by an opportunistic bacterial infection in NSG mice. Affected animals exhibited perianal fecal staining, dehydration, and wasting. Histopathologic lesions included a primary necrotizing enterocolitis, with inflammatory and necrotizing lesions also occurring in the liver, kidneys, heart, and brain of some mice. All affected individuals tested negative for known opportunistic pathogens of immunodeficient mice. We initially identified a member of Enterobacter cloacae complex (ECC) in association with the outbreak by traditional diagnostics. ECC was cultured from extraintest...
Source: Toxicologic Pathology - March 13, 2024 Category: Pathology Authors: Catherine Si Kourtney Nickerson Taylor Simmons Parker Denton M Russell Nichols Robert C Dysko Mark Hoenerhoff Rinosh Mani Cheryl Woods Kenneth S Henderson Zachary T Freeman Source Type: research
Next-Generation Sequencing-Based Identification of < em > Enterobacter hormaechei < /em > as Causative Agent of High Mortality Disease in NOD.Cg- < em > Prkdc < sup > scid < /sup > < /em > < em > Il2rg < sup > tm1Wjl < /sup > < /em > /SzJ (NSG) Mice
We describe a high mortality disease outbreak caused by an opportunistic bacterial infection in NSG mice. Affected animals exhibited perianal fecal staining, dehydration, and wasting. Histopathologic lesions included a primary necrotizing enterocolitis, with inflammatory and necrotizing lesions also occurring in the liver, kidneys, heart, and brain of some mice. All affected individuals tested negative for known opportunistic pathogens of immunodeficient mice. We initially identified a member of Enterobacter cloacae complex (ECC) in association with the outbreak by traditional diagnostics. ECC was cultured from extraintest...
Source: Toxicologic Pathology - March 13, 2024 Category: Pathology Authors: Catherine Si Kourtney Nickerson Taylor Simmons Parker Denton M Russell Nichols Robert C Dysko Mark Hoenerhoff Rinosh Mani Cheryl Woods Kenneth S Henderson Zachary T Freeman Source Type: research
Next-Generation Sequencing-Based Identification of < em > Enterobacter hormaechei < /em > as Causative Agent of High Mortality Disease in NOD.Cg- < em > Prkdc < sup > scid < /sup > < /em > < em > Il2rg < sup > tm1Wjl < /sup > < /em > /SzJ (NSG) Mice
We describe a high mortality disease outbreak caused by an opportunistic bacterial infection in NSG mice. Affected animals exhibited perianal fecal staining, dehydration, and wasting. Histopathologic lesions included a primary necrotizing enterocolitis, with inflammatory and necrotizing lesions also occurring in the liver, kidneys, heart, and brain of some mice. All affected individuals tested negative for known opportunistic pathogens of immunodeficient mice. We initially identified a member of Enterobacter cloacae complex (ECC) in association with the outbreak by traditional diagnostics. ECC was cultured from extraintest...
Source: Toxicologic Pathology - March 13, 2024 Category: Pathology Authors: Catherine Si Kourtney Nickerson Taylor Simmons Parker Denton M Russell Nichols Robert C Dysko Mark Hoenerhoff Rinosh Mani Cheryl Woods Kenneth S Henderson Zachary T Freeman Source Type: research
Next-Generation Sequencing-Based Identification of < em > Enterobacter hormaechei < /em > as Causative Agent of High Mortality Disease in NOD.Cg- < em > Prkdc < sup > scid < /sup > < /em > < em > Il2rg < sup > tm1Wjl < /sup > < /em > /SzJ (NSG) Mice
We describe a high mortality disease outbreak caused by an opportunistic bacterial infection in NSG mice. Affected animals exhibited perianal fecal staining, dehydration, and wasting. Histopathologic lesions included a primary necrotizing enterocolitis, with inflammatory and necrotizing lesions also occurring in the liver, kidneys, heart, and brain of some mice. All affected individuals tested negative for known opportunistic pathogens of immunodeficient mice. We initially identified a member of Enterobacter cloacae complex (ECC) in association with the outbreak by traditional diagnostics. ECC was cultured from extraintest...
Source: Toxicologic Pathology - March 13, 2024 Category: Pathology Authors: Catherine Si Kourtney Nickerson Taylor Simmons Parker Denton M Russell Nichols Robert C Dysko Mark Hoenerhoff Rinosh Mani Cheryl Woods Kenneth S Henderson Zachary T Freeman Source Type: research
Next-Generation Sequencing-Based Identification of < em > Enterobacter hormaechei < /em > as Causative Agent of High Mortality Disease in NOD.Cg- < em > Prkdc < sup > scid < /sup > < /em > < em > Il2rg < sup > tm1Wjl < /sup > < /em > /SzJ (NSG) Mice
We describe a high mortality disease outbreak caused by an opportunistic bacterial infection in NSG mice. Affected animals exhibited perianal fecal staining, dehydration, and wasting. Histopathologic lesions included a primary necrotizing enterocolitis, with inflammatory and necrotizing lesions also occurring in the liver, kidneys, heart, and brain of some mice. All affected individuals tested negative for known opportunistic pathogens of immunodeficient mice. We initially identified a member of Enterobacter cloacae complex (ECC) in association with the outbreak by traditional diagnostics. ECC was cultured from extraintest...
Source: Toxicologic Pathology - March 13, 2024 Category: Pathology Authors: Catherine Si Kourtney Nickerson Taylor Simmons Parker Denton M Russell Nichols Robert C Dysko Mark Hoenerhoff Rinosh Mani Cheryl Woods Kenneth S Henderson Zachary T Freeman Source Type: research
Deep Learning-Based Spermatogenic Staging in Tissue Sections of Cynomolgus Macaque Testes
Toxicol Pathol. 2024 Mar 11:1926233241234059. doi: 10.1177/01926233241234059. Online ahead of print.ABSTRACTThe indirect assessment of adverse effects on fertility in cynomolgus monkeys requires that tissue sections of the testis be microscopically evaluated with awareness of the stage of spermatogenesis that a particular cross-section of a seminiferous tubule is in. This difficult and subjective task could very much benefit from automation. Using digital whole slide images (WSIs) from tissue sections of testis, we have developed a deep learning model that can annotate the stage of each tubule with high sensitivity, precis...
Source: Toxicologic Pathology - March 11, 2024 Category: Pathology Authors: Lars Mecklenburg C Marc Luetjens Annette Romeike Rohit Garg Pranab Samanta Amogh Mohanty Tijo Thomas Gerhard Weinbauer Source Type: research
Deep Learning-Based Spermatogenic Staging in Tissue Sections of Cynomolgus Macaque Testes
Toxicol Pathol. 2024 Mar 11:1926233241234059. doi: 10.1177/01926233241234059. Online ahead of print.ABSTRACTThe indirect assessment of adverse effects on fertility in cynomolgus monkeys requires that tissue sections of the testis be microscopically evaluated with awareness of the stage of spermatogenesis that a particular cross-section of a seminiferous tubule is in. This difficult and subjective task could very much benefit from automation. Using digital whole slide images (WSIs) from tissue sections of testis, we have developed a deep learning model that can annotate the stage of each tubule with high sensitivity, precis...
Source: Toxicologic Pathology - March 11, 2024 Category: Pathology Authors: Lars Mecklenburg C Marc Luetjens Annette Romeike Rohit Garg Pranab Samanta Amogh Mohanty Tijo Thomas Gerhard Weinbauer Source Type: research
Expression of Concern
Toxicol Pathol. 2024 Mar 7:1926233241238763. doi: 10.1177/01926233241238763. Online ahead of print.NO ABSTRACTPMID:38450642 | DOI:10.1177/01926233241238763 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - March 7, 2024 Category: Pathology Source Type: research
