Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies
This article outlines "points to consider" for sample collection, processing, evaluation, interpretation, and reporting of ganglion findings; these points are consistent with published best practices for peripheral nervous system evaluation in nonclinical toxicity studies. Ganglion findings often occur as a combination of neuronal injury (e.g., degeneration, necrosis, and/or loss) and/or glial effects (e.g., increased satellite glial cell cellularity) with leukocyte accumulation (e.g., mononuclear cell infiltration or inflammation). Nerve fiber degeneration and/or glial reactions may be seen in nerves, dorsal spinal nerve ...
Source: Toxicologic Pathology - July 25, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah Cramer LaTasha K Crawford Jeffery A Engelhardt Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies
This article outlines "points to consider" for sample collection, processing, evaluation, interpretation, and reporting of ganglion findings; these points are consistent with published best practices for peripheral nervous system evaluation in nonclinical toxicity studies. Ganglion findings often occur as a combination of neuronal injury (e.g., degeneration, necrosis, and/or loss) and/or glial effects (e.g., increased satellite glial cell cellularity) with leukocyte accumulation (e.g., mononuclear cell infiltration or inflammation). Nerve fiber degeneration and/or glial reactions may be seen in nerves, dorsal spinal nerve ...
Source: Toxicologic Pathology - July 25, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah Cramer LaTasha K Crawford Jeffery A Engelhardt Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies
This article outlines "points to consider" for sample collection, processing, evaluation, interpretation, and reporting of ganglion findings; these points are consistent with published best practices for peripheral nervous system evaluation in nonclinical toxicity studies. Ganglion findings often occur as a combination of neuronal injury (e.g., degeneration, necrosis, and/or loss) and/or glial effects (e.g., increased satellite glial cell cellularity) with leukocyte accumulation (e.g., mononuclear cell infiltration or inflammation). Nerve fiber degeneration and/or glial reactions may be seen in nerves, dorsal spinal nerve ...
Source: Toxicologic Pathology - July 25, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah Cramer LaTasha K Crawford Jeffery A Engelhardt Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Points to Consider: Sampling, Processing, Evaluation, Interpretation, and Reporting of Test Article-Related Ganglion Pathology for Nonclinical Toxicity Studies
This article outlines "points to consider" for sample collection, processing, evaluation, interpretation, and reporting of ganglion findings; these points are consistent with published best practices for peripheral nervous system evaluation in nonclinical toxicity studies. Ganglion findings often occur as a combination of neuronal injury (e.g., degeneration, necrosis, and/or loss) and/or glial effects (e.g., increased satellite glial cell cellularity) with leukocyte accumulation (e.g., mononuclear cell infiltration or inflammation). Nerve fiber degeneration and/or glial reactions may be seen in nerves, dorsal spinal nerve ...
Source: Toxicologic Pathology - July 25, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah Cramer LaTasha K Crawford Jeffery A Engelhardt Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
