Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
