Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies
Toxicol Pathol. 2023 Sep 13:1926233231193395. doi: 10.1177/01926233231193395. Online ahead of print.ABSTRACTDuring toxicology studies, fasting animals prior to clinical pathology blood collection is believed to reduce variability in some clinical chemistry analytes. However, fasting adds stress to animals that are already stressed from the administration of potentially toxic doses of the test article. The purpose of this study was to assess the impacts of different fasting durations on cynomolgus monkeys' welfare during toxicology studies. To this end, we assessed the cynomolgus monkeys traditional and ancillary clinical p...
Source: Toxicologic Pathology - September 13, 2023 Category: Pathology Authors: Adeyemi O Adedeji Tony Pourmohamad Niraj Tripathi Shelly Zhong Kenna R Degner Fiona Zhong Dewakar Sangaraju Kevin Williams Noel Dybdal Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
