Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology
Toxicol Pathol. 2023 Aug 26:1926233231191128. doi: 10.1177/01926233231191128. Online ahead of print.ABSTRACTAssessment of hypertensive tubulopathy for more than fifty animal models of hypertension in experimental pathology employs criteria that do not correspond to lesional descriptors for tubular lesions in clinical pathology. We provide a critical appraisal of experimental hypertension with the same approach used to estimate hypertensive renal tubulopathy in humans. Four models with different pathogenesis of hypertension were analyzed-chronic angiotensin (Ang) II-infused and renin-overexpressing (TTRhRen) mice, spontaneo...
Source: Toxicologic Pathology - August 26, 2023 Category: Pathology Authors: Alex A Gutsol Taben M Hale Jean-Francois Thibodeau Chet E Holterman Rania Nasrallah Jose W N Correa Rhian M Touyz Chris R J Kennedy Dylan Burger Richard L H ébert Kevin D Burns Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
Musings on Education for Toxicologic Pathology Proficiency in a Post-pandemic, Remotely Working World
Toxicol Pathol. 2023 Aug 14:1926233231190403. doi: 10.1177/01926233231190403. Online ahead of print.NO ABSTRACTPMID:37578161 | DOI:10.1177/01926233231190403 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Brad Bolon Source Type: research
Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics
Toxicol Pathol. 2023 Aug 14:1926233231190382. doi: 10.1177/01926233231190382. Online ahead of print.ABSTRACTThe evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development. Toxicologic pathologists play critical roles in identifying immune system changes that drive the immunosafety determination. Standard pathology evaluations of therapies and chemicals remain similar; however, biopharmaceutical therapies have moved from simply affecting the immune system to being specifically developed to modify the immune system, which can impact in...
Source: Toxicologic Pathology - August 14, 2023 Category: Pathology Authors: Tracey L Papenfuss Lauren Himmel C Frieke Kuper Sunish Mohanan Johannes Harleman Susan A Elmore Source Type: research
