Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
Translational Relevance of Rodent Models to Predict Human Liver Disease
Toxicol Pathol. 2024 Mar 18:1926233241230543. doi: 10.1177/01926233241230543. Online ahead of print.ABSTRACTAnimals models are essential to understand the complex pathobiology of human diseases. George Box's aphorism based on statistics "All models are wrong, but some are useful" certainly applies to animal models of disease. In this session, the translational relevance of various animal models applicable to human liver disease was explored starting with a historic overview of the rodent cancer bioassay with emphasis on hepatocarcinogenesis from early work at the National Cancer Institute, refinement by the National Toxico...
Source: Toxicologic Pathology - March 18, 2024 Category: Pathology Authors: Debabrata Mahapatra Robert Maronpot Source Type: research
