Corrigendum to Histology Atlas of the Developing Mouse Placenta
Toxicol Pathol. 2023 May 9:1926233231175051. doi: 10.1177/01926233231175051. Online ahead of print.NO ABSTRACTPMID:37160757 | DOI:10.1177/01926233231175051 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - May 10, 2023 Category: Pathology Source Type: research
Corrigendum to Histology Atlas of the Developing Mouse Placenta
Toxicol Pathol. 2023 May 9:1926233231175051. doi: 10.1177/01926233231175051. Online ahead of print.NO ABSTRACTPMID:37160757 | DOI:10.1177/01926233231175051 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - May 10, 2023 Category: Pathology Source Type: research
Corrigendum to Histology Atlas of the Developing Mouse Placenta
Toxicol Pathol. 2023 May 9:1926233231175051. doi: 10.1177/01926233231175051. Online ahead of print.NO ABSTRACTPMID:37160757 | DOI:10.1177/01926233231175051 (Source: Toxicologic Pathology)
Source: Toxicologic Pathology - May 10, 2023 Category: Pathology Source Type: research
Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model
Toxicol Pathol. 2023 May 9:1926233231171101. doi: 10.1177/01926233231171101. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood. We investigated whether NAFLD can influence acetaminophen (APAP [N-acetyl-p-aminophenol])-induced hepatotoxicity in a diet-induced obese (DIO) mouse model of NAFLD. The male C57BL/6NTac DIO mice, fed a high-fat diet for more than 12 weeks, developed obesity, hyperinsulinemia, impaired glucose tolerance, and hepatomegaly with hepatic steatosis, similar to human NAFLD....
Source: Toxicologic Pathology - May 9, 2023 Category: Pathology Authors: Takeshi Izawa Gregory S Travlos Ricardo A Cortes Natasha P Clayton Robert C Sills Arun R Pandiri Source Type: research
Assessing the Carcinogenicity of Vadadustat, an Oral Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, in Rodents
Toxicol Pathol. 2023 May 9:1926233231168836. doi: 10.1177/01926233231168836. Online ahead of print.ABSTRACTVadadustat is an investigational oral hypoxia-inducible factor (HIF) prolyl-4-hydroxylase inhibitor to treat anemia due to chronic kidney disease (CKD). Some studies suggest that HIF activation promotes tumorigenesis by activating angiogenesis downstream of vascular endothelial growth factor, while other studies suggest that elevated HIF activity may produce an antitumor phenotype. To evaluate the potential carcinogenicity of vadadustat in mice and rats, we dosed CByB6F1/Tg.rasH2 hemizygous (transgenic) mice orally by...
Source: Toxicologic Pathology - May 9, 2023 Category: Pathology Authors: Heather Kowalski Debie Hoivik Michael Rabinowitz Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
Investigation of the Proliferative Potential of FGF21 or FGF19 in Liver-Specific FGFR4-Deficient Mice
Toxicol Pathol. 2023 Apr 26:1926233231164097. doi: 10.1177/01926233231164097. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) and FGF15/FGF19 belong to the same subgroup of FGFs and are believed to have therapeutic potential in the treatment of type 2 diabetes and associated metabolic dysfunctionalities and pathological conditions. FGF19 has been proposed to induce hyperplasia and liver tumors in FVB mice (named after its susceptibility to Friend leukemia virus B), mediated by the FGF receptor 4 (FGFR4). The goal of this work was to investigate whether FGF21 might also have a potential proliferative effec...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Kerstin W äse Thomas Bartels Uwe Schwahn Mostafa Kabiri Source Type: research
Toxicologic Pathology Forum: Opinion on Performing Good Laboratory Practice Histopathology Evaluation for Nonclinical Toxicity Studies in a Remote Location
Toxicol Pathol. 2023 Apr 26:1926233231168133. doi: 10.1177/01926233231168133. Online ahead of print.ABSTRACTToxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonly in home-office settings. A study pathologist (SP) generating data on GLP-compliant nonclinical studies must be keenly aware of applicable national GLP regulations and comply with TF and protocol requirements. This Toxicological Pathology Forum Opinion Piece will summarize primary areas of emphasis for the SP generating GLP data using glass slides. Peer review and digi...
Source: Toxicologic Pathology - April 26, 2023 Category: Pathology Authors: Renee R Hukkanen Michelle Trapani Tana Derringer Victoria Laast Zbigniew W Wojcinski Rosa Anna Manno Matthias Rinke Eric van Esch Alys E Bradley Patrizia Cristofori Roger Alison Barb Munch Source Type: research
