Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing
This article reviews ganglion anatomy, cytology, and pathology (emphasizing sensory ganglia) among common nonclinical species used in assessing product safety for such test articles (TAs). Principal histopathologic findings associated with sensory ganglion injury include neuron degeneration, necrosis, and/or loss; increased satellite glial cell and/or Schwann cell numbers; and leukocyte infiltration and/or inflammation. Secondary nerve fiber degeneration and/or glial reactions may occur in nerves, dorsal spinal nerve roots, spinal cord (dorsal and occasionally lateral funiculi), and sometimes the brainstem. Ganglion findin...
Source: Toxicologic Pathology - December 4, 2023 Category: Pathology Authors: Bindu M Bennet Ingrid D Pardo Basel T Assaf Elizabeth Buza Sarah D Cramer LaTasha K Crawford Jeffery A Engelhardt Elizabeth J Galbreath Branka Grubor James P Morrison Tanasa S Osborne Alok K Sharma Brad Bolon Source Type: research
