GREM1 knockdown regulates the proliferation, apoptosis and EMT of benign prostatic hyperplasia by suppressing the STAT3/c-Myc signaling
CONCLUSION: To sum up, GREM1 silencing may alleviate the BPH progress by inhibiting the STAT3/c-Myc signaling.PMID:37931534 | DOI:10.1016/j.tice.2023.102231 (Source: Tissue and Cell)
Source: Tissue and Cell - November 6, 2023 Category: Cytology Authors: Xiaofei Sun Minjun Jiang Zhenfan Wang Chen Xu Zheng Ma Source Type: research
Ferulago angulata extract alleviates testicular toxicity in male mice exposed to diazinon and lead
In this study, we investigated the protective effects of Ferulago angulata extract (FAE) against the reproductive toxicants Diazinon (DZN) and Lead (Pb) in mice. These pollutants are known to induce oxidative stress (OS), while FAE acts as a natural antioxidant. Adult male NMRI mice were exposed to DZN, Pb, and DZN+Pb, with or without FAE treatment for six weeks. We evaluated OS markers, testicular histology, and expression of mRNA related to enzymatic antioxidants. Exposure to DZN and Pb led to increased levels of thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) in the testes, along with a decrease in ...
Source: Tissue and Cell - November 4, 2023 Category: Cytology Authors: Nushin Naderi Manouchehr Souri Mohammad Hossein Nasr-Esfahani Mehdi Hajian Mohammad Naser Nazem Source Type: research
Ferulago angulata extract alleviates testicular toxicity in male mice exposed to diazinon and lead
In this study, we investigated the protective effects of Ferulago angulata extract (FAE) against the reproductive toxicants Diazinon (DZN) and Lead (Pb) in mice. These pollutants are known to induce oxidative stress (OS), while FAE acts as a natural antioxidant. Adult male NMRI mice were exposed to DZN, Pb, and DZN+Pb, with or without FAE treatment for six weeks. We evaluated OS markers, testicular histology, and expression of mRNA related to enzymatic antioxidants. Exposure to DZN and Pb led to increased levels of thiobarbituric acid reactive substance (TBARS) and nitric oxide (NO) in the testes, along with a decrease in ...
Source: Tissue and Cell - November 4, 2023 Category: Cytology Authors: Nushin Naderi Manouchehr Souri Mohammad Hossein Nasr-Esfahani Mehdi Hajian Mohammad Naser Nazem Source Type: research
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Tissue Cell. 2023 Oct 24;85:102256. doi: 10.1016/j.tice.2023.102256. Online ahead of print.ABSTRACTReproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against CP-induced testicular toxicity in rats for the first time. Male Sprague-Dawley rats received a single dose of CP (5 mg/kg; intraperitoneal) and treated with GTA (1.5 and 3 mg/kg; intraperitoneal; 3 consecutive days). The levels of oxidative stress (OS), inflammation, endoplasmic reticulum stress (ERS) and apoptosi...
Source: Tissue and Cell - November 2, 2023 Category: Cytology Authors: Ahmet Mentese Selim Demir Sevdegul Aydin Mungan Nihal Turkmen Alemdar Elif Ayazoglu Demir Yuksel Aliyazicioglu Source Type: research
Decellularized tracheal scaffold as a promising 3D scaffold for tissue engineering applications
Tissue Cell. 2023 Oct 25;85:102258. doi: 10.1016/j.tice.2023.102258. Online ahead of print.ABSTRACTTissue engineering is a science that uses the combination of scaffolds, cells, and active biomolecules to make tissue in order to restore or maintain its function and improve the damaged tissue or even an organ in the laboratory. The purpose of this research was to study the characteristics and biocompatibility of decellularized sheep tracheal scaffolds and also to investigate the differentiation of Adipose-derived stem cells (AD-MSCs) into tracheal cells. After the decellularization of sheep tracheas through the detergent-en...
Source: Tissue and Cell - November 2, 2023 Category: Cytology Authors: Aida Nahumi Maryam Peymani Asadollah Asadi Arash Abdolmaleki Yassin Panahi Source Type: research
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Tissue Cell. 2023 Oct 24;85:102256. doi: 10.1016/j.tice.2023.102256. Online ahead of print.ABSTRACTReproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against CP-induced testicular toxicity in rats for the first time. Male Sprague-Dawley rats received a single dose of CP (5 mg/kg; intraperitoneal) and treated with GTA (1.5 and 3 mg/kg; intraperitoneal; 3 consecutive days). The levels of oxidative stress (OS), inflammation, endoplasmic reticulum stress (ERS) and apoptosi...
Source: Tissue and Cell - November 2, 2023 Category: Cytology Authors: Ahmet Mentese Selim Demir Sevdegul Aydin Mungan Nihal Turkmen Alemdar Elif Ayazoglu Demir Yuksel Aliyazicioglu Source Type: research
Decellularized tracheal scaffold as a promising 3D scaffold for tissue engineering applications
Tissue Cell. 2023 Oct 25;85:102258. doi: 10.1016/j.tice.2023.102258. Online ahead of print.ABSTRACTTissue engineering is a science that uses the combination of scaffolds, cells, and active biomolecules to make tissue in order to restore or maintain its function and improve the damaged tissue or even an organ in the laboratory. The purpose of this research was to study the characteristics and biocompatibility of decellularized sheep tracheal scaffolds and also to investigate the differentiation of Adipose-derived stem cells (AD-MSCs) into tracheal cells. After the decellularization of sheep tracheas through the detergent-en...
Source: Tissue and Cell - November 2, 2023 Category: Cytology Authors: Aida Nahumi Maryam Peymani Asadollah Asadi Arash Abdolmaleki Yassin Panahi Source Type: research
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
Tissue Cell. 2023 Oct 24;85:102256. doi: 10.1016/j.tice.2023.102256. Online ahead of print.ABSTRACTReproductive toxicity is a serious side effect of cisplatin (CP) chemotherapy. Gentisic acid (GTA) is a phenolic acid with strong antioxidant properties. Here, we aimed to determine therapeutic effect of GTA against CP-induced testicular toxicity in rats for the first time. Male Sprague-Dawley rats received a single dose of CP (5 mg/kg; intraperitoneal) and treated with GTA (1.5 and 3 mg/kg; intraperitoneal; 3 consecutive days). The levels of oxidative stress (OS), inflammation, endoplasmic reticulum stress (ERS) and apoptosi...
Source: Tissue and Cell - November 2, 2023 Category: Cytology Authors: Ahmet Mentese Selim Demir Sevdegul Aydin Mungan Nihal Turkmen Alemdar Elif Ayazoglu Demir Yuksel Aliyazicioglu Source Type: research
Decellularized tracheal scaffold as a promising 3D scaffold for tissue engineering applications
Tissue Cell. 2023 Oct 25;85:102258. doi: 10.1016/j.tice.2023.102258. Online ahead of print.ABSTRACTTissue engineering is a science that uses the combination of scaffolds, cells, and active biomolecules to make tissue in order to restore or maintain its function and improve the damaged tissue or even an organ in the laboratory. The purpose of this research was to study the characteristics and biocompatibility of decellularized sheep tracheal scaffolds and also to investigate the differentiation of Adipose-derived stem cells (AD-MSCs) into tracheal cells. After the decellularization of sheep tracheas through the detergent-en...
Source: Tissue and Cell - November 2, 2023 Category: Cytology Authors: Aida Nahumi Maryam Peymani Asadollah Asadi Arash Abdolmaleki Yassin Panahi Source Type: research
Placental mesenchymal stem cells-secreted proenkephalin suppresses the p38 MAPK signaling to block hyperproliferation of keloid fibroblasts
CONCLUSION: This work unravels that PMSCs-secreted PENK suppresses the p38 MAPK signaling to block hyperproliferation of KFs.PMID:37913601 | DOI:10.1016/j.tice.2023.102218 (Source: Tissue and Cell)
Source: Tissue and Cell - November 1, 2023 Category: Cytology Authors: Di Wu Xiao Liu Zhehu Jin Source Type: research
Salvianolic acid B exerts protective effects against A β-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 polarization
CONCLUSION: our study demonstrated, for the first time, that the anti-inflammatory effects of SalB were mediated by the regulation of NLRP3 activation and promotion of microglial M2 polarization, indicating the potential of SalB as a novel therapeutic candidate for AD.PMID:37913602 | DOI:10.1016/j.tice.2023.102260 (Source: Tissue and Cell)
Source: Tissue and Cell - November 1, 2023 Category: Cytology Authors: Yuan Zhao Xin Liu Xiang Liu Jian Zhang Yidan Zhang Ya Wen Guofeng Yang Source Type: research
Lysine demethylase 3A in hypoxic macrophages promotes ovarian cancer development through regulation of the vascular endothelial growth factor A/Akt signaling
CONCLUSION: The KDM3A content and M2 polarization were enhanced in hypoxic macrophages, and KDM3A in hypoxic macrophages promoted OC development through regulation of the VEGF/Akt signaling pathway.PMID:37890327 | DOI:10.1016/j.tice.2023.102253 (Source: Tissue and Cell)
Source: Tissue and Cell - October 27, 2023 Category: Cytology Authors: Yan Song Liming Li Yan Xi Source Type: research
Lysine demethylase 3A in hypoxic macrophages promotes ovarian cancer development through regulation of the vascular endothelial growth factor A/Akt signaling
CONCLUSION: The KDM3A content and M2 polarization were enhanced in hypoxic macrophages, and KDM3A in hypoxic macrophages promoted OC development through regulation of the VEGF/Akt signaling pathway.PMID:37890327 | DOI:10.1016/j.tice.2023.102253 (Source: Tissue and Cell)
Source: Tissue and Cell - October 27, 2023 Category: Cytology Authors: Yan Song Liming Li Yan Xi Source Type: research
Lysine demethylase 3A in hypoxic macrophages promotes ovarian cancer development through regulation of the vascular endothelial growth factor A/Akt signaling
CONCLUSION: The KDM3A content and M2 polarization were enhanced in hypoxic macrophages, and KDM3A in hypoxic macrophages promoted OC development through regulation of the VEGF/Akt signaling pathway.PMID:37890327 | DOI:10.1016/j.tice.2023.102253 (Source: Tissue and Cell)
Source: Tissue and Cell - October 27, 2023 Category: Cytology Authors: Yan Song Liming Li Yan Xi Source Type: research
Lysine demethylase 3A in hypoxic macrophages promotes ovarian cancer development through regulation of the vascular endothelial growth factor A/Akt signaling
CONCLUSION: The KDM3A content and M2 polarization were enhanced in hypoxic macrophages, and KDM3A in hypoxic macrophages promoted OC development through regulation of the VEGF/Akt signaling pathway.PMID:37890327 | DOI:10.1016/j.tice.2023.102253 (Source: Tissue and Cell)
Source: Tissue and Cell - October 27, 2023 Category: Cytology Authors: Yan Song Liming Li Yan Xi Source Type: research
