Benefits of conditioned medium of nicotine-pulsed mesenchymal stem cells in experimental autoimmune hepatitis
Tissue Cell. 2024 Mar 13;88:102359. doi: 10.1016/j.tice.2024.102359. Online ahead of print.ABSTRACTPrevious data indicated that nicotine could modulate the immune regulatory potential of mesenchymal stem cells (MSCs). Currently, we intend to assess the effects of a conditioned medium of nicotine-pulsed mesenchymal stem cells in the experimental model of autoimmune hepatitis (AIH). Bone marrow-derived MSCs pulsed with 0,.1,.5, or 1 μM nicotine until the cells reached 90% confluency. Correspondent to in vitro results, the least effective concentration of nicotine that led to an anti-inflammatory environment by the MSC-condi...
Source: Tissue and Cell - March 23, 2024 Category: Cytology Authors: Leila Mahmoudzadeh Seyyed Meysam Abtahi Froushani Rahim Hobbenaghi Alireza Mahmoudian Vahid Mohammadi Source Type: research
Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath
Tissue Cell. 2024 Mar 2;88:102344. doi: 10.1016/j.tice.2024.102344. Online ahead of print.ABSTRACTTelomerase is present in cells with numerous or even un-limited replicative cycles, and some studies suggest it is a stemness marker. In order to determine whether this is the case for the human hair bulbs, an immunohistochemical and ultrastructural study has been carried out using antibodies against telomerase and PCNA (a cell proliferation marker). The observed labeling is similar for the two antibodies here utilized and is mainly nuclear. More frequent telomerase-positive cells are seen in the matrix epithelium of anagen ha...
Source: Tissue and Cell - March 21, 2024 Category: Cytology Authors: Lorenzo Alibardi Source Type: research
Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath
Tissue Cell. 2024 Mar 2;88:102344. doi: 10.1016/j.tice.2024.102344. Online ahead of print.ABSTRACTTelomerase is present in cells with numerous or even un-limited replicative cycles, and some studies suggest it is a stemness marker. In order to determine whether this is the case for the human hair bulbs, an immunohistochemical and ultrastructural study has been carried out using antibodies against telomerase and PCNA (a cell proliferation marker). The observed labeling is similar for the two antibodies here utilized and is mainly nuclear. More frequent telomerase-positive cells are seen in the matrix epithelium of anagen ha...
Source: Tissue and Cell - March 21, 2024 Category: Cytology Authors: Lorenzo Alibardi Source Type: research
The impact of diabetic glucose concentration on viability and cardiac differentiation of mesenchymal stem cells
CONCLUSION: Diabetic glucose concentration inhibits normal proliferation and cardiac differentiation of MSCs. This effect should be considered in stem cell therapy of cardiovascular patients who are concurrently affected by hyperglycemia, a common comorbidity in such individuals. Why carry out this study? What was learned from the study?PMID:38502970 | DOI:10.1016/j.tice.2024.102361 (Source: Tissue and Cell)
Source: Tissue and Cell - March 19, 2024 Category: Cytology Authors: Shadi Nosrati Maryam Gheisari Shahrokh Zare Mahintaj Dara Samaneh Zolghadri Iman Razeghian-Jahromi Source Type: research
The impact of diabetic glucose concentration on viability and cardiac differentiation of mesenchymal stem cells
CONCLUSION: Diabetic glucose concentration inhibits normal proliferation and cardiac differentiation of MSCs. This effect should be considered in stem cell therapy of cardiovascular patients who are concurrently affected by hyperglycemia, a common comorbidity in such individuals. Why carry out this study? What was learned from the study?PMID:38502970 | DOI:10.1016/j.tice.2024.102361 (Source: Tissue and Cell)
Source: Tissue and Cell - March 19, 2024 Category: Cytology Authors: Shadi Nosrati Maryam Gheisari Shahrokh Zare Mahintaj Dara Samaneh Zolghadri Iman Razeghian-Jahromi Source Type: research
The impact of diabetic glucose concentration on viability and cardiac differentiation of mesenchymal stem cells
CONCLUSION: Diabetic glucose concentration inhibits normal proliferation and cardiac differentiation of MSCs. This effect should be considered in stem cell therapy of cardiovascular patients who are concurrently affected by hyperglycemia, a common comorbidity in such individuals. Why carry out this study? What was learned from the study?PMID:38502970 | DOI:10.1016/j.tice.2024.102361 (Source: Tissue and Cell)
Source: Tissue and Cell - March 19, 2024 Category: Cytology Authors: Shadi Nosrati Maryam Gheisari Shahrokh Zare Mahintaj Dara Samaneh Zolghadri Iman Razeghian-Jahromi Source Type: research
Modulatory effects of Moringa oleifera leaf extract on sodium nitrate-induced experimental colitis via regulation of P53, Ki-67 and PCNA biomarkers
CONCLUSION: MO protected the colonic mucosa against SN-induced changes regulating apoptosis, and cell proliferation.PMID:38493756 | DOI:10.1016/j.tice.2024.102327 (Source: Tissue and Cell)
Source: Tissue and Cell - March 17, 2024 Category: Cytology Authors: Hend M Hassan Wael M Elsaed Dina Elzeiny Ola Ali Habotta Elshimaa S Eleraky Eman Mohamed El Nashar Mansour Abdullah Alghamdi Rashid A Aldahhan Mohammed Attieh Alzahrani Ali Mohni Saleh Alamari Eman Hamza Source Type: research
Investigation into effects of tocilizumab and epoetin beta in rats with experimental sciatic nerve injury model
CONCLUSIONS: TCZ and EPO decreased nerve injury effects by increasing motor and sensory conduction velocities of the sciatic nerve. Biochemically, TCZ and EPO significantly increased Superoxide Dismutase, Catalase, and Glutathione peroxidase 4 levels while decreasing Lipid Peroxidation levels (p=0.001). Histopathologically, neuronal degeneration following nerve injury was decreased in the groups receiving TCZ and EPO (p=0.001). EPO and TCZ attenuate the adverse effects of nerve injury. However, the TCZ+EPO treatment favoured biochemical activities over tissue and functional activities. This has been confirmed functionally,...
Source: Tissue and Cell - March 17, 2024 Category: Cytology Authors: Aysun G üler Kanter Harun Ülger Ahmet Sarper Bozkurt Mehmet Tarak çıoğlu İbrahim Hanefi Özercan Hasan Ulusal Source Type: research
Ultrastructural study of neuronal cells and localization of ghrelin-like peptide and its receptor in the ganglia of the golden apple snail (Pomacea canaliculata)
Tissue Cell. 2024 Mar 5;88:102348. doi: 10.1016/j.tice.2024.102348. Online ahead of print.ABSTRACTPomacea canaliculata is an invasive snail species causing major problems in agriculture. The snail biology was then investigated. The main objective of the present study was to investigate the nervous system of the snail. The nervous system comprises pairs of cerebral, buccal, pedal, pleural, parietal ganglia and an unpaired visceral ganglion. Most neurons were concentrated at the periphery of the ganglia. The neurons were classified into four types: NR1, NR2, NR3, and NR4. The percentages of the NR3 and NR4 in the pleural and...
Source: Tissue and Cell - March 17, 2024 Category: Cytology Authors: Piyada Ngernsoungnern Piyachat Rungsawang Athiphat Janthaweera Pornsawan Duangsuwan Naruwan Saowakon Pishyaporn Sritangos Apichart Ngernsoungnern Source Type: research
Modulatory effects of Moringa oleifera leaf extract on sodium nitrate-induced experimental colitis via regulation of P53, Ki-67 and PCNA biomarkers
CONCLUSION: MO protected the colonic mucosa against SN-induced changes regulating apoptosis, and cell proliferation.PMID:38493756 | DOI:10.1016/j.tice.2024.102327 (Source: Tissue and Cell)
Source: Tissue and Cell - March 17, 2024 Category: Cytology Authors: Hend M Hassan Wael M Elsaed Dina Elzeiny Ola Ali Habotta Elshimaa S Eleraky Eman Mohamed El Nashar Mansour Abdullah Alghamdi Rashid A Aldahhan Mohammed Attieh Alzahrani Ali Mohni Saleh Alamari Eman Hamza Source Type: research
Investigation into effects of tocilizumab and epoetin beta in rats with experimental sciatic nerve injury model
CONCLUSIONS: TCZ and EPO decreased nerve injury effects by increasing motor and sensory conduction velocities of the sciatic nerve. Biochemically, TCZ and EPO significantly increased Superoxide Dismutase, Catalase, and Glutathione peroxidase 4 levels while decreasing Lipid Peroxidation levels (p=0.001). Histopathologically, neuronal degeneration following nerve injury was decreased in the groups receiving TCZ and EPO (p=0.001). EPO and TCZ attenuate the adverse effects of nerve injury. However, the TCZ+EPO treatment favoured biochemical activities over tissue and functional activities. This has been confirmed functionally,...
Source: Tissue and Cell - March 17, 2024 Category: Cytology Authors: Aysun G üler Kanter Harun Ülger Ahmet Sarper Bozkurt Mehmet Tarak çıoğlu İbrahim Hanefi Özercan Hasan Ulusal Source Type: research
Ultrastructural study of neuronal cells and localization of ghrelin-like peptide and its receptor in the ganglia of the golden apple snail (Pomacea canaliculata)
Tissue Cell. 2024 Mar 5;88:102348. doi: 10.1016/j.tice.2024.102348. Online ahead of print.ABSTRACTPomacea canaliculata is an invasive snail species causing major problems in agriculture. The snail biology was then investigated. The main objective of the present study was to investigate the nervous system of the snail. The nervous system comprises pairs of cerebral, buccal, pedal, pleural, parietal ganglia and an unpaired visceral ganglion. Most neurons were concentrated at the periphery of the ganglia. The neurons were classified into four types: NR1, NR2, NR3, and NR4. The percentages of the NR3 and NR4 in the pleural and...
Source: Tissue and Cell - March 17, 2024 Category: Cytology Authors: Piyada Ngernsoungnern Piyachat Rungsawang Athiphat Janthaweera Pornsawan Duangsuwan Naruwan Saowakon Pishyaporn Sritangos Apichart Ngernsoungnern Source Type: research
Sumatriptan mitigates bleomycin-induced lung fibrosis in male rats: Involvement of inflammation, oxidative stress and α-SMA
CONCLUSION: According to the data achieved from this study, Sumatriptan appears to have therapeutic benefits in IPF, possibly via reducing α-SMA as well as inflammation and the toxicity caused by oxidative stress.PMID:38492426 | DOI:10.1016/j.tice.2024.102349 (Source: Tissue and Cell)
Source: Tissue and Cell - March 16, 2024 Category: Cytology Authors: Ayda Bahramifar Razieh Mohammad Jafari Mohammad Sheibani Mohammad Amin Manavi Amir Rashidian Seyed Mohammad Tavangar Mostafa Akbariani Amirabbas Mohammadi Hamaneh Ramin Goudarzi Amir Shadboorestan Ahmad Reza Dehpour Source Type: research
Sumatriptan mitigates bleomycin-induced lung fibrosis in male rats: Involvement of inflammation, oxidative stress and α-SMA
CONCLUSION: According to the data achieved from this study, Sumatriptan appears to have therapeutic benefits in IPF, possibly via reducing α-SMA as well as inflammation and the toxicity caused by oxidative stress.PMID:38492426 | DOI:10.1016/j.tice.2024.102349 (Source: Tissue and Cell)
Source: Tissue and Cell - March 16, 2024 Category: Cytology Authors: Ayda Bahramifar Razieh Mohammad Jafari Mohammad Sheibani Mohammad Amin Manavi Amir Rashidian Seyed Mohammad Tavangar Mostafa Akbariani Amirabbas Mohammadi Hamaneh Ramin Goudarzi Amir Shadboorestan Ahmad Reza Dehpour Source Type: research
Effect of intermittent fasting on adriamycin-induced nephropathy: Possible underlying mechanisms
CONCLUSION: AQP2, Sirt1, Nrf2/HO-1 signaling may be upregulated and activated by IF, which alleviates ADR nephropathy. Enhancing endogenous antioxidants, reducing apoptosis and tubulointerstitial damage, and maintaining the glomerular membrane's integrity are other goals.PMID:38489913 | DOI:10.1016/j.tice.2024.102360 (Source: Tissue and Cell)
Source: Tissue and Cell - March 15, 2024 Category: Cytology Authors: Fathy H Elsaid Abdelaziz M Hussein Elsayed A Eid Omar A Ammar Ali Ali Khalil Source Type: research
