NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma through regulation of ERG-mediated FABP4
This study provided evidence that NKX2-1-AS1 regulated FABP4 transcription by binding to ERG to facilitate the proliferation and migration of LUAD cells and tube formation of HLECs, thus participating in lymphangiogenesis.PMID:38309204 | DOI:10.1016/j.tice.2024.102314 (Source: Tissue and Cell)
Source: Tissue and Cell - February 3, 2024 Category: Cytology Authors: Ting Tao Hui Chen Qimei Xu Zhen Li Xuelian Chen Xunjian Zhou Wu Luo Source Type: research

Effects and mechanisms of prussian blue nanozymes with multiple enzyme activities on nasopharyngeal carcinoma cells
This study lays a solid biomedical foundation for the development of safe and non-toxic nanozymes, as well as the expansion of their application in tumor treatment.PMID:38301585 | DOI:10.1016/j.tice.2024.102316 (Source: Tissue and Cell)
Source: Tissue and Cell - February 1, 2024 Category: Cytology Authors: Ya Pan Xiaofeng Wang Qi Tan Liping Wang Source Type: research

Quercetin mitigates doxorubicin-induced neurodegenerative changes in the cerebral cortex and hippocampus of rats; insights to DNA damage, inflammation, synaptic plasticity
CONCLUSIONS: It can be concluded that QE induces protective effects against Dox-induced neurotoxicity.PMID:38286061 | DOI:10.1016/j.tice.2024.102313 (Source: Tissue and Cell)
Source: Tissue and Cell - January 29, 2024 Category: Cytology Authors: Eman S El-Shetry Ibrahim Amin Ibrahim Asmaa Mahde Kamel Ola Ali Abdelwahab Source Type: research

Effects of probiotic supplementation on chronic inflammatory process modulation in colorectal carcinogenesis
Tissue Cell. 2024 Jan 12;87:102293. doi: 10.1016/j.tice.2023.102293. Online ahead of print.ABSTRACTThe current study investigated the potential effects of probiotic supplementation on colorectal carcinogenesis chemically induced with 1,2-dimethylhydrazine (DMH) and treated with 5-fluorouracil (5FU)-based chemotherapy in mice. Animals were randomly allocated in five different groups: Control: which not receive any treatment throughout the experimental course; Colitis model group (DMH): treated with DMH; DMH+ 5FU: animals received I.P. (intraperitoneal) dose of chemotherapy on a weekly basis; DMH+PROB: animals received daily...
Source: Tissue and Cell - January 20, 2024 Category: Cytology Authors: Sabrina Karen Reis Eduardo Augusto Rabelo Socca Bianca Ribeiro de Souza Sandra Cristina Genaro Nelson Dur án Wagner Jos é Fávaro Source Type: research

The knockdown of stathmin with si-RNA inhibits invasion of mesothelioma
CONCLUSIONS: Immunohistochemical analysis of STMN1 may contribute to the differential diagnosis of MSM, and STMN1 may also be considered as a potential therapeutic target in the early invasive stage of MSM therapy.PMID:38244401 | DOI:10.1016/j.tice.2024.102303 (Source: Tissue and Cell)
Source: Tissue and Cell - January 20, 2024 Category: Cytology Authors: Asude Aksoy Asuman Varoglu Ebru Etem Onalan Ahmet Tektemur Gokhan Artas Mustafa Koc Muharrem Cakmak Siyami Aydin Murat Kilic Mustafa Ulas Source Type: research

Comparative histological description of the intestine in platyfish (Xiphophorus maculatus) and swordtail fish (Xiphophorus helleri)
This study aimed to provide a comprehensive analysis of the histological structure of intestinal tissues of platyfish (Xiphophorus maculatus) and swordtail fish (Xiphophorus helleri). Specifically, the objectives were: (1) to compare the structural adaptations of their intestines related to their distinct feeding habits, diet, and digestive strategies; and (2) to explore their potential as animal models for intestinal disease research. Through detailed examination of tissue morphology, cell types, and structural features, this study found that both species lack a stomach, with the intestine directly connected to the esopha...
Source: Tissue and Cell - January 18, 2024 Category: Cytology Authors: Marta Gon çalves C élia Lopes Paula Silva Source Type: research

Effect of exogenous genistein on osteogenic differentiation of adipose-derived mesenchymal stem cells in laying hens
Tissue Cell. 2024 Jan 4;87:102299. doi: 10.1016/j.tice.2023.102299. Online ahead of print.ABSTRACTPrevious literature revealed that genistein might play a preventive role in osteoporosis. Therefore, we aimed to evaluate the effect of genistein on the osteogenic potency of laying hens' adipose-derived stem cells (LHASCs). The viability of LHASCs after isolation was investigated on tissue culture plastic (TCP) under exposure to genistein up to 50 μg/mL by MTT assay. Our preliminary result revealed that LHASCs cultured under genistein exposure up to 20 μg/mL are feasible. Then, we evaluated the osteogenic induction of LHASC...
Source: Tissue and Cell - January 16, 2024 Category: Cytology Authors: Farhang Ahmadian Mehrdad Irani Abdollah Mohammadi-Sangcheshmeh Source Type: research

Three-dimensional printing and decellularized-extracellular-matrix based methods for advances in artificial blood vessel fabrication: A review
Tissue Cell. 2024 Jan 5;87:102304. doi: 10.1016/j.tice.2024.102304. Online ahead of print.ABSTRACTBlood vessels are the tubes through which blood flows and are divided into three types: millimeter-scale arteries, veins, and capillaries as well as micrometer-scale capillaries. Arteries and veins are the conduits that carry blood, while capillaries are where blood exchanges substances with tissues. Blood vessels are mainly composed of collagen fibers, elastic fibers, glycosaminoglycans and other macromolecular substances. There are about 19 feet of blood vessels per square inch of skin in the human body, which shows how impo...
Source: Tissue and Cell - January 14, 2024 Category: Cytology Authors: Bing Li Yan Shu Hailin Ma Kun Cao Yuen Yee Cheng Zhilin Jia Xiao Ma Hongfei Wang Kedong Song Source Type: research

Three-dimensional bioengineered dermal derived matrix scaffold in combination with adipose-derived stem cells accelerate diabetic wound healing
Tissue Cell. 2024 Jan 5;87:102302. doi: 10.1016/j.tice.2024.102302. Online ahead of print.ABSTRACTDue to the multifactorial nature of diabetic wounds, the most effective treatments require combinatorial approach. Herein we investigated whether engraftment of a bioengineered three-dimensional dermal derived matrix scaffold (DDMS) in combination with adipose-derived stem cells (ADSs), could accelerate diabetic wound healing. Diabetic animals were randomly planned into the control group, DDMS group, ADS group, and DDMS+ADS group. On days 7, 14, and 21, tissue samples were obtained for stereological, molecular, and tensiometri...
Source: Tissue and Cell - January 14, 2024 Category: Cytology Authors: Fatemeh Bour Shayan Khalilollah Melody Omraninava Mohamad Sedigh Mirzaie Saeid Taghiloo Sophia Mehrparvar Davood Nasiry Amir Raoofi Source Type: research

Corrigendum to 'Morphological analysis of neck muscle nerves and neurons in cats' [Tissue and Cell 82 (2023) 1-11/102077]
Tissue Cell. 2024 Jan 13:102301. doi: 10.1016/j.tice.2024.102301. Online ahead of print.NO ABSTRACTPMID:38220546 | DOI:10.1016/j.tice.2024.102301 (Source: Tissue and Cell)
Source: Tissue and Cell - January 14, 2024 Category: Cytology Authors: Kazumasa Sasaki Sei-Ichi Sasaki Fumi Sato Source Type: research

Alpinetin alleviates LPS-induced lung epithelial cell injury by inhibiting p38 and ERK1/2 signaling via aquaporin-1
In this study, acute lung injury (ALI) model was constructed by inducing MLE-12 cells with lipopolysaccharide (LPS). Cell activity together with apoptosis was judged employing cell counting kit-8 (CCK-8), flow cytometry along with western blot. Oxidative stress levels were measured by dichloro-dihydro-fluorescein diacetate (DCFH-DA) staining and corresponding kits. In addition, enzyme-linked immunosorbent assay (ELISA) was to examine the levels of inflammatory factors. The protein expressions of aquaporin-1 (AQP1), p38 and extracellular signal-regulated kinase (ERK) 1/2 pathway were estimated utilizing western blot. The da...
Source: Tissue and Cell - January 13, 2024 Category: Cytology Authors: Junjie Zhang Bin Ma Source Type: research

Scutellarin alleviates tensile stress-induced proliferation and migration of venous smooth muscle cells via mediating the p38 MAPK pathway
CONCLUSION: Scutellarin alleviates tension stress-induced proliferation and migration of VSMCs via suppressing p38 MAPK pathway. Scutellarin may be used as an adjunctive strategy for future GABG treatment in CHD patients.PMID:38211409 | DOI:10.1016/j.tice.2024.102300 (Source: Tissue and Cell)
Source: Tissue and Cell - January 11, 2024 Category: Cytology Authors: Hu Zhang Ling Lin Ailing Yang Yasha Liang Bo Huang Source Type: research

Comparison of differential protein expression of the marginal transitional zone in neonatal and weanling-aged foals
Tissue Cell. 2023 Dec 30;87:102295. doi: 10.1016/j.tice.2023.102295. Online ahead of print.ABSTRACTThe marginal transitional zone (MTZ) is peripherally located within the diarthrodial joint, and represents the junction of synovium, fibrous joint capsule, articular cartilage, periosteum, and bone. The purpose of this study is to characterize age-related differences in protein expression of matrix and molecular regulators in the marginal transitional zone of neonatal and weanling foals. Several families of proteins with known roles in cartilage and bone development are investigated, including matrix molecules, members of the...
Source: Tissue and Cell - January 10, 2024 Category: Cytology Authors: Stacy A Semevolos Elizabeth A Marchant Source Type: research

Sevoflurane postconditioning alleviates hypoxic-ischemic brain damage in rats by inhibiting the endoplasmic reticulum stress PERK/ATF4/CHOP pathway
In conclusion, SPC alleviates neuronal apoptosis in the hippocampus CA1 area of HIBD rats by inhibiting the endoplasmic reticulum stress pathway PERK/ATF4/CHOP, thereby mitigating HIBD in rats.PMID:38194851 | DOI:10.1016/j.tice.2023.102289 (Source: Tissue and Cell)
Source: Tissue and Cell - January 9, 2024 Category: Cytology Authors: Qionghua Hu Lingqin Qiu Li Ge Yi Wei Source Type: research

Long-term protective effects of lamotrigine in a rat ovarian ischemia-reperfusion model
In this study, we aimed to investigate the long-term anatomical, histological and biochemical protective effects of lamotrigine in ovariums in the ischemia - reperfusion (I-R) model created experimentally in rats. A total of 40 female Sprague-Dawley rats, 14 weeks old, weighing 220-270 g were used in the study. The subjects were randomly distributed to form 4 groups named SHAM group, I - R group, I - R + Lamotrigine (LTG) group and R + LTG group. Under general anesthesia, the ovaries of the rats were reached and ischemia was created for 3 h with vascular clamps. 20 mg / kg LTG was administered intraperitoneally (ip.) to gr...
Source: Tissue and Cell - January 9, 2024 Category: Cytology Authors: Riza Aktepe Yilmaz Ucuncu Levent Tumkaya Tolga Mercantepe Atilla Topcu Huseyin Avni Uydu Mehtap Atak Source Type: research