Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone)
In conclusion, DOX exposure leads to renal toxicity by inducing renal degeneration, oxidative stress, and apoptosis. Administration of either resveratrol or Pirfenidone counteracted these changes and protected the kidney against DOX-induced renal damage.PMID:38412579 | DOI:10.1016/j.tice.2024.102330 (Source: Tissue and Cell)
Source: Tissue and Cell - February 27, 2024 Category: Cytology Authors: Samia Mahmoud Manawy Eman Mohamed Faruk Rabab Fawzy Hindawy Mahmoud M Hassan Diaa M G Farrag Mansour A E Bashar Hanan Fouad Rania Abubaker Bagabir Dina Allam Abdelmaksoud Hassan Ahmed Mohammed Zaazaa Mohamed Ghazy Attia Hablas K Mostafa Kamal Source Type: research
Peiminine triggers ferroptosis to inhibit breast cancer growth through triggering Nrf2 signaling
CONCLUSION: Taking these finding together, PMI could stimulate ferroptosis to inhibit BC tumor growth by activating Nrf2-HO-1 signaling pathway.PMID:38412577 | DOI:10.1016/j.tice.2024.102323 (Source: Tissue and Cell)
Source: Tissue and Cell - February 27, 2024 Category: Cytology Authors: Nian Yi Li Wang Zhongjun Jiang Ge Xu Lihong Li Ya Zhang Yinna Tan Source Type: research
A comprehensive exploration of diverse skin cell types in the limb of the desert tortoise (Testudo graeca) through light, transmission, scanning electron microscopy, and immunofluorescence techniques
Tissue Cell. 2024 Feb 23;87:102335. doi: 10.1016/j.tice.2024.102335. Online ahead of print.ABSTRACTThe Greek tortoise, inhabiting harsh desert environments, provides a compelling case for investigating skin adaptations to extreme conditions. We have utilized light microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and immunofluorescence analysis to describe the structure of the arid-adapted limb skin in the Greek tortoise. Our aim was to identify the cell types that reflect the skin adaptation of this tortoise to arid conditions. Utilizing seven antibodies, we localized and elucidated t...
Source: Tissue and Cell - February 27, 2024 Category: Cytology Authors: Ahmed M Rashwan Samir A A El-Gendy Samar M Ez Elarab Mohamed A M Alsafy Source Type: research
Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone)
In conclusion, DOX exposure leads to renal toxicity by inducing renal degeneration, oxidative stress, and apoptosis. Administration of either resveratrol or Pirfenidone counteracted these changes and protected the kidney against DOX-induced renal damage.PMID:38412579 | DOI:10.1016/j.tice.2024.102330 (Source: Tissue and Cell)
Source: Tissue and Cell - February 27, 2024 Category: Cytology Authors: Samia Mahmoud Manawy Eman Mohamed Faruk Rabab Fawzy Hindawy Mahmoud M Hassan Diaa M G Farrag Mansour A E Bashar Hanan Fouad Rania Abubaker Bagabir Dina Allam Abdelmaksoud Hassan Ahmed Mohammed Zaazaa Mohamed Ghazy Attia Hablas K Mostafa Kamal Source Type: research
RASFF1A inhibits the epithelial-mesenchymal transition of lens epithelial cells induced by TGF β through regulating HDAC6
Tissue Cell. 2024 Feb 7;87:102325. doi: 10.1016/j.tice.2024.102325. Online ahead of print.ABSTRACTTo explore the role of Ras-association domain family 1 A (RASSF1A) in TGFβ2-induced changes of lens epithelial cells (LECs) behavior. The human LEC line SRA01/04 cells were treated with TGFβ2 in the presence or absence of RASSF1A and histone deacetylase 6 (HDAC6). qRT-PCR and western blot were performed to analysis mRNA and proteins expression. Cell proliferation was evaluated using MTT assay and colony formation assay. Transwell and scratch-wound healing assays were conducted to detected cell migration ability. RASSF1A was ...
Source: Tissue and Cell - February 23, 2024 Category: Cytology Authors: Mingda Ma Yunkai Lv Kun Zhang Lina Zhou Source Type: research
RASFF1A inhibits the epithelial-mesenchymal transition of lens epithelial cells induced by TGF β through regulating HDAC6
Tissue Cell. 2024 Feb 7;87:102325. doi: 10.1016/j.tice.2024.102325. Online ahead of print.ABSTRACTTo explore the role of Ras-association domain family 1 A (RASSF1A) in TGFβ2-induced changes of lens epithelial cells (LECs) behavior. The human LEC line SRA01/04 cells were treated with TGFβ2 in the presence or absence of RASSF1A and histone deacetylase 6 (HDAC6). qRT-PCR and western blot were performed to analysis mRNA and proteins expression. Cell proliferation was evaluated using MTT assay and colony formation assay. Transwell and scratch-wound healing assays were conducted to detected cell migration ability. RASSF1A was ...
Source: Tissue and Cell - February 23, 2024 Category: Cytology Authors: Mingda Ma Yunkai Lv Kun Zhang Lina Zhou Source Type: research
RASFF1A inhibits the epithelial-mesenchymal transition of lens epithelial cells induced by TGF β through regulating HDAC6
Tissue Cell. 2024 Feb 7;87:102325. doi: 10.1016/j.tice.2024.102325. Online ahead of print.ABSTRACTTo explore the role of Ras-association domain family 1 A (RASSF1A) in TGFβ2-induced changes of lens epithelial cells (LECs) behavior. The human LEC line SRA01/04 cells were treated with TGFβ2 in the presence or absence of RASSF1A and histone deacetylase 6 (HDAC6). qRT-PCR and western blot were performed to analysis mRNA and proteins expression. Cell proliferation was evaluated using MTT assay and colony formation assay. Transwell and scratch-wound healing assays were conducted to detected cell migration ability. RASSF1A was ...
Source: Tissue and Cell - February 23, 2024 Category: Cytology Authors: Mingda Ma Yunkai Lv Kun Zhang Lina Zhou Source Type: research
The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats
Tissue Cell. 2024 Feb 15;87:102328. doi: 10.1016/j.tice.2024.102328. Online ahead of print.ABSTRACTParkinson's disease (PD) is one of the most common neurodegenerative conditions. Alpha-synuclein deposition, Lewy bodies (LBs) formation, disruption of the autophagic machinery, apoptosis of substantia nigra dopaminergic neurons, oxidative stress, and neuroinflammation are all pathologic hallmarks of PD. The leaves of the stinging Nettle (Urtica dioica L.) have a long history as an herbal cure with antioxidant, anti-inflammatory, anti-cancer, immunomodulatory, and neuroprotective properties. The current study aims for the fir...
Source: Tissue and Cell - February 22, 2024 Category: Cytology Authors: Emad Albadawi Ahmed El-Tokhy Muayad Albadrani Mohammed Adel Randa El-Gamal Wael Zaarina Mosaab Salah El-Din El-Agawy Hassan Reda Hassan Elsayed Source Type: research
The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats
Tissue Cell. 2024 Feb 15;87:102328. doi: 10.1016/j.tice.2024.102328. Online ahead of print.ABSTRACTParkinson's disease (PD) is one of the most common neurodegenerative conditions. Alpha-synuclein deposition, Lewy bodies (LBs) formation, disruption of the autophagic machinery, apoptosis of substantia nigra dopaminergic neurons, oxidative stress, and neuroinflammation are all pathologic hallmarks of PD. The leaves of the stinging Nettle (Urtica dioica L.) have a long history as an herbal cure with antioxidant, anti-inflammatory, anti-cancer, immunomodulatory, and neuroprotective properties. The current study aims for the fir...
Source: Tissue and Cell - February 22, 2024 Category: Cytology Authors: Emad Albadawi Ahmed El-Tokhy Muayad Albadrani Mohammed Adel Randa El-Gamal Wael Zaarina Mosaab Salah El-Din El-Agawy Hassan Reda Hassan Elsayed Source Type: research
Differentiation of Wharton's Jelly-derived mesenchymal stem cells into insulin-producing beta cells with the enhanced functional level on electrospun PRP-PVP-PCL/PCL fiber scaffold
In this study, to differentiate Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) into insulin-producing cells (IPCs) with improved maturity, and function, platelet-rich plasma (PRP)-Polyvinylpyrrolidone (PVP)-Polycaprolactone (PCL)/PCL scaffold was designed. The two-dimensional (2D) control group included cell culture without differentiation medium, and the experimental groups included 2D, and three-dimensional (3D) groups with pancreatic beta cell differentiation medium. WJ-MSCs-derived IPCs on PRP-PVP-PCL/PCL scaffold took round cluster morphology, the typical pancreatic islets morphology. Real-time PCR, immunocy...
Source: Tissue and Cell - February 20, 2024 Category: Cytology Authors: Seyed Mohammad Javad Hashemi Seyed Ehsan Enderami Ali Barzegar Reyhaneh Nassiri Mansour Source Type: research
Differentiation of Wharton's Jelly-derived mesenchymal stem cells into insulin-producing beta cells with the enhanced functional level on electrospun PRP-PVP-PCL/PCL fiber scaffold
In this study, to differentiate Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) into insulin-producing cells (IPCs) with improved maturity, and function, platelet-rich plasma (PRP)-Polyvinylpyrrolidone (PVP)-Polycaprolactone (PCL)/PCL scaffold was designed. The two-dimensional (2D) control group included cell culture without differentiation medium, and the experimental groups included 2D, and three-dimensional (3D) groups with pancreatic beta cell differentiation medium. WJ-MSCs-derived IPCs on PRP-PVP-PCL/PCL scaffold took round cluster morphology, the typical pancreatic islets morphology. Real-time PCR, immunocy...
Source: Tissue and Cell - February 20, 2024 Category: Cytology Authors: Seyed Mohammad Javad Hashemi Seyed Ehsan Enderami Ali Barzegar Reyhaneh Nassiri Mansour Source Type: research
Differentiation of Wharton's Jelly-derived mesenchymal stem cells into insulin-producing beta cells with the enhanced functional level on electrospun PRP-PVP-PCL/PCL fiber scaffold
In this study, to differentiate Wharton's Jelly-derived mesenchymal stem cells (WJ-MSCs) into insulin-producing cells (IPCs) with improved maturity, and function, platelet-rich plasma (PRP)-Polyvinylpyrrolidone (PVP)-Polycaprolactone (PCL)/PCL scaffold was designed. The two-dimensional (2D) control group included cell culture without differentiation medium, and the experimental groups included 2D, and three-dimensional (3D) groups with pancreatic beta cell differentiation medium. WJ-MSCs-derived IPCs on PRP-PVP-PCL/PCL scaffold took round cluster morphology, the typical pancreatic islets morphology. Real-time PCR, immunocy...
Source: Tissue and Cell - February 20, 2024 Category: Cytology Authors: Seyed Mohammad Javad Hashemi Seyed Ehsan Enderami Ali Barzegar Reyhaneh Nassiri Mansour Source Type: research
Neuroprotective mechanism of ribisin A on H < sub > 2 < /sub > O < sub > 2 < /sub > -induced PC12 cell injury model
Tissue Cell. 2024 Feb 3;87:102322. doi: 10.1016/j.tice.2024.102322. Online ahead of print.ABSTRACTRibisin A has been shown to have neurotrophic activity. The aim of this study was to evaluate the neuroprotective effect of ribisin A on injured PC12 cells and elucidate its mechanism. In this project, PC12 cells were induced by H2O2 to establish an injury model. After treatment with ribisin A, the neuroprotective mechanism of ribisin A was investigated by methyl tetrazolium (MTT) assay, Enzyme-linked immunosorbent assay (ELISA), flow cytometric analysis, fluorescent probe analysis, and western blot. We found that ribisin A de...
Source: Tissue and Cell - February 17, 2024 Category: Cytology Authors: Xin Zhang Mengyu Bao Jingyi Zhang Lihao Zhu Di Wang Xin Liu Lingchuan Xu Lijuan Luan Yuguo Liu Yuhong Liu Source Type: research
Hepatoprotective impact of Nigella sativa silver nanocomposite against genotoxicity, oxidative stress, and inflammation induced by thioacetamide
Tissue Cell. 2024 Feb 15;87:102332. doi: 10.1016/j.tice.2024.102332. Online ahead of print.ABSTRACTProtection from liver damage and the repercussion of that harm is thought to be crucial for reducing the number of deaths each year. This work was developed to evaluate the possible role of silver nanocomposite prepared using Nigella sativa (N. sativa) aqueous extract against the hepatic damage brought on by thioacetamide (TAA), with particular attention to how they affect the NF-κβ, TNF-α, IL-1β, and COX-2 signaling pathways. There were seven groups of male Wistar rats used as follows: control, saline, N. sativa aqueous ...
Source: Tissue and Cell - February 17, 2024 Category: Cytology Authors: Fatma M El-Demerdash Ansam B Al Mhanna Raghda A El-Sayed Tarek M Mohamed Maha M Salem Source Type: research
Possible involvement of HtrA1 serine protease in the onset of osteoporotic bone extracellular matrix changes
Tissue Cell. 2024 Feb 13;87:102329. doi: 10.1016/j.tice.2024.102329. Online ahead of print.ABSTRACTHigh-temperature requirement A1 (HtrA1), a multidomain serine protease acting on Extracellular matrix (ECM) rearrangement, is also secreted by osteoblasts and osteoclasts. Recent and conflicting literature highlights HtrA1's role as a controller of bone remodeling, proposing it as a possible target for pathologies with unbalanced bone resorption, like Osteoporosis (OP). To add knowledge on this molecule function in bone physiopathology, here we compared HtrA1 distribution in the ECM of healthy (H) and OP bone tissue, also exa...
Source: Tissue and Cell - February 17, 2024 Category: Cytology Authors: C Licini S Fantone D Lamanna G Tossetta D Marzioni M Mattioli Belmonte Source Type: research
