Mast Cells and Vascular Endothelial Growth Factor Contribute to Pelvic Tactile Allodynia in a Non-invasive Mouse Model of Endometriosis
Endometriosis (EM) impacts ~4 million women in the US. EM lesions are infiltrated with mast cells (MCs) and have elevated vascular endothelial growth factor (VEGF). To test the hypothesis that MC and VEGF drive endometriosis-associated pelvic pain, we assessed therapeutic agents on pelvic tactile allodynia in a mouse model of EM. C57BL/6J donor mice (6-weeks old) received a subcutaneous injection of estradiol benzoate (10 µg), and 4 days later, each uterine horn was excised and placed in Hank’s Balanced Salt Solution (HBSS) and minced. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Pranav Prasoon, Sarvesh Acharya, Bradley K. Taylor, Kenny M. Roman Source Type: research
The Bidirectional Impact of Arginine-Vasopressin Receptor 1a (Avpr1a/AVPR1A) and the Gut Microbiome on Visceral Hypersensitivity
Visceral hypersensitivity (VH) is commonly cited as a driver of chronic abdominal pain in disorders of gut-brain interactions (DGBI) where persistent and/or recurrent abdominal pain is a primary symptom regardless of any alterations in bowel habits. Development of VH is influenced by genetic, environmental, and gut microbial colonization factors, yet specific mechanisms that generate VH are incompletely understood. Correspondingly, current pain treatments for DGBI, including irritable bowel syndrome (IBS), primarily focus on symptom management and severity rather than targeting the pathophysiological mechanisms underlying ...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Leena Kader, Adam Willits, Julie A. Christianson, Kyle Baumbauer, Jun-Ho La, Bin Feng, Brittany Knight, Gulum Kosova, Jennifer Deberry, Matthew Coates, Erin E. Young Source Type: research
Voluntary Wheel Running Improves Hippocampal Integrity and Urogenital Hypersensitivity in Adult Mice Exposed to Neonatal Maternal Separation
This study aimed to determine whether exercise could attenuate acute water avoidance stress (WAS)-induced exacerbation of urogenital hypersensitivity and altered hippocampal neurochemical levels in NMS mice. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Tara E McQuillan, Rebecca M Foright, Jenna M Frick, Carly Gagnon, Brittni M Levasseur, Munish Chauhan, In Young Choi, Phil Lee, Julie A Christianson Source Type: research
Clinical and Somatosensory Profile of Patients with C1-2 Atlanto-Axial Pain
To comprehensively phenotype patients with acute and chronic pain from the atlanto-axial (C1-2) segment. Patients with acute ( (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Cathryn Payne, Natalie Yap, Abby Chiu, Julia Bergquist, Jin Wang, Asta Arendt-Tranholm, Marisol Mancilla Moreno, Christoph Hofstetter, Judith Turner, Ted Price, Michele Curatolo Tags: Acute to Chronic Pain Source Type: research
Effectiveness Of Inpatient Rehabilitation for Pediatric Patients with Complex Regional Pain Syndrome
The cornerstone of treatment for pediatric Complex Regional Pain Syndrome (CRPS) patients include rehabilitative treatment encompassing physical therapy (PT), medications, and pain psychology with a focus on Cognitive Behavioral Therapy (CBT). Treatment can occur in both the inpatient and outpatient setting. Currently there is no consensus as to whether outpatient therapy is superior to intensive inpatient therapy. A review of the literature found few high-quality studies suggesting the efficacy of inpatient rehabilitation for pediatric patients with CRPS. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Hiba Zafar, Jessica Justmann Source Type: research
Exploring Definitions of Acute Low Back Pain Severity as Predictors of Transition to Chronic Low Back Pain: A Community-Based Longitudinal Pilot Study
The characterization of acute low back pain (LBP) and its association with the transition from acute to chronic LBP is poorly defined. The purpose of this study is to explore acute LBP severity definitions and determine their performance as predictors of transition to chronic LBP in a community-based sample of adults. We enrolled 131 participants with acute ( (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Rebecca Fillipo, Colleen Burke, Andrzej Kosinski, Steven Z. George, Flavia Kapos, Adam Goode Source Type: research
Exploring Novel Therapeutic Targets in Inflammatory Pain: Insights from the CFA-Induced Paw Pain Model in Mice
In this study, mice were subjected to CFA-induced inflammation in the paw, mimicking aspects of rheumatoid arthritis, and subsequently assessed for behavioral (tactile and thermal allodynia) and biological (edema and inflammation assessment in paw samples) changes. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kendall Walker, Carla Cancio, Oc éane Pélouin, David Babin, Evelyne Sablé, Solène Pédron Source Type: research
Humanized Non-opioid Therapy for Pain Management: CCKB Receptor scFv
Small single-chain Fragment variable (scFv) antibodies were designed based on upregulation of cholecystokinin B receptor (Cckbr) mRNA in ganglia of chronic trigeminal orofacial pain models in mice compared to controls. CCKBR is also a target known to be upregulated in chronic pain, anxiety, and depression. scFvs are composed of VH and VL portions of IgGs joined with a flexible linker. They are 30% smaller than monoclonal antibodies allowing brain/nervous tissue penetration demonstrated by Western blot. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Karin N Westlund, Ian Adams, Nesia Zurek, Sascha RA Alles, June Bryan de la Pe ña Source Type: research
Investigating The Role of The Parabrachial Nucleus to Central Amygdala Pathway in The Transition from Acute to Chronic Pain in a Mouse Model of Neuropathic Pain
The parabrachial nucleus (PbN) transmits nociceptive information from the spinal cord to the brain. The central amygdala (CeA) modulates emotions and pain and is a target of the PBN. Potentiation of synaptic transmission in the PbN-to-CeA pathway after injury has been shown in different rodent pain models. Further studies demonstrated that this pathway participates in escape, aversion, and injury-induced hypersensitivity. However, previous studies only evaluated early time-points following injury. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Torri D. Wilson, Sudhuman Singh, Jeitzel M. Torres-Rodriguez, Yarimar Carrasquillo Source Type: research
Low Pain Self-Efficacy as a Psychological Factor Associated with High Impact Chronic Pain
Self-efficacy, or one ’s ability to overcome challenges and achieve goals, is a critical psychological resilience factor that aids understanding motivation, behavioral change, and health status of people living with various challenging health conditions, such as chronic pain. The current cross-sectional study examined the relationship between pain self-efficacy and high impact chronic pain (HICP). We recruited 262 patients with mixed etiology of chronic pain (65% Female, 79% White, mean age = 58 years with SD = 16) to complete the Chronic Pain Self-Efficacy Scale (CPSS) and Graded Chronic Pain Scale-Revised (GCPS -R). (S...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Emma Raney, Kenneth Weber, Sean C. Mackey, Dokyoung S. You Source Type: research
Mast-Cell-Derived Proteases Mediate Resolution of Inflammatory Pain in Mice
Immune cells play a critical role regulating the transition from acute to chronic pain, however, while the initiation of inflammatory pain is relatively understood (Ji, 2016), the mechanism behind the resolution is unclear. Mast cells reside in the skin and because of their proximity to sensory nervous, a tight interplay with nociceptors has long been proposed (Hendriksen, 2017; Morellini, 2018; Mittal, 2019). These interactions may be beneficial or detrimental, suggesting their participation in pain modulation. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sabrina de Souza, Kufreobong E. Inyang, Hannah Hua, Jaewon Sim, Sophie Laumet, Joseph Folger, Adam Moeser, Geoffroy Laumet Source Type: research
Psychological Predictors of Pain Three Months After Severe Musculoskeletal Injury
Chronic pain and disability are likely outcomes after severe musculoskeletal injuries. Psychological factors measured during recovery have been shown to be associated with recovery. The purpose of this study was to evaluate if a robust set of psychological factors, measured during hospitalization and immediate recovery, predict pain intensity, pain interference and physical functioning three months after hospitalization. Participants (N=131) were prospectively recruited during hospitalization with orthopaedic trauma (i.e., fracture) and data was collected at hospitalization and three months later. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Eric Kruger, Matthew Wharton, Chris Shultz, Will Curtis, Danielle Cummings Source Type: research
Spinal Cord Expression and Function of Complement C5aR1 Receptor in Neuropathic Pain
Chronic pain affects approximately 100 million Americans and only a minority of patients experience satisfactory relief of their pain with currently available pharmaceutics. One type of chronic pain is caused by direct injury to the nerve called neuropathic pain, which affects ~10% of the overall population. Despite the prevalence, the underlying mechanisms of neuropathic pain are not well-defined, and better understanding of the mechanisms that promote central sensitization after injury could lead to better treatment of this condition. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kiley Christopher, Alex Keyes, Kavita Solanki, Yaroslav Andrianov, L. Shutov, C Warwick, Trent Woodruff, P. Belan, N. Voitenko, Yuriy Usachev Source Type: research
The Impact of Sociodemographic Factors on Pain Resilience among Adults with Chronic Low Back Pain
Much chronic pain research is focused on psychosocial risk factors, but examination of the potential protective role of positive and adaptive factors, like pain resiliency, is critical. The purpose of this study was to investigate the impact of sociodemographic factors (i.e., racialized group) on pain resilience in adults with chronic low back pain (cLBP). Adults (n=192; 114 Black, 78 White, 109 female, 83 male, 45.5 ± 14.5 years of age) with cLBP completed questionnaires on pain resilience and overall pain and disability. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Asia M. Wiggins, Terence M. Penn, Demario S. Overstreet, Larissa J. Strath, Joanna M. Hobson, Shivraj S. Grewal, Jonas G. Dembowski, Andrew M. Sims, Tammie L. Quinn, Robert E. Sorge, Burel R. Goodin Source Type: research
The Link Between Trauma and Chronic Pain: Exploring the Role of Pain Flashbacks in Chronic Pain Following Interpersonal Trauma
This study proposes and investigates a new mechanism pertaining to the role of intrusive pain flashbacks for explaining the association between CA, C/PTSD, and chronic pain following interpersonal trauma. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Noga Tsur Source Type: research
