Analgesic Effect of delta-9-Tetrahydrocannabinol Alone and of a 1:1 delta-9-Tetrahydrocannabinol: Cannabidiol Formulation in Chronic Neuropathic Pain: Two Pilot Studies
These ongoing preliminary studies explore the efficacy of delta-9-tetrahydro-cannabinol (THC) alone and in a 1:1 combination with cannabidiol (CBD) in subjects with neuropathic pain (NP) in a dose-controlled process using oral formulations. Eligible subjects are 18 to 75 years of age with a diagnosis of NP existing for two or more months, not currently using marijuana or any related substances, and available to be seen weekly. On a daily basis they complete a 0 –10 pain diary three times, and record how much of their pain medications are taken. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: F Goldstein, K Galluzzi, B Bach, M Brown, J Smith, J Lubeck, M Lent Source Type: research
Applying Evidence-Based Quality Improvement Methods to Adapt an Intervention for Implementation Within Diverse Healthcare Systems: Findings from the CORPs Pragmatic Effectiveness Trial
Veterans living in rural areas with chronic pain often utilize multiple systems of care, including the VA and community care. The Tele-Collaborative Outreach to Rural Patients with Chronic Pain (CORPs) is a pragmatic effectiveness trial testing the utility of collaborative care for rural veterans with high impact chronic pain. This presentation highlights results of formative implementation efforts made to adapt CORPs to diverse VA healthcare systems covering rural catchments from eight different states. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Natassja Pal, Sarah S. Ono, Benjamin J. Morasco, Benjamin J. Morasco, Una E. Makris, Amanda S. Mixon, Erin E. Krebs, Melinda M. Davis, Steven K. Dobscha, Travis I. Lovejoy Source Type: research
Electromyography-Biofeedback for Episodic Migraines: A Qualitative Cohort Study
Surface electromyography-biofeedback (sEMG-BF) may reduce the burden of episodic migraines by improving physical functioning, sleep, pain catastrophizing, anxiety, and depression. This qualitative study investigated the impact of weekly EMG-BF sessions on adults with episodic migraines. 88 individuals with Episodic migraines participated in telephone interviews after completing an 6-week virtual sEMG-BF intervention. Trained interviewers conducted the 10-to-15-minute semi-structured interviews to understand participants' experience with the intervention. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Marie Curiel, Jason Sadora, Mackenzie Maynard, Myrella Paschali, Timothy Wilkins, Robert Edwards, Asimina Lazaridou Source Type: research
Fostering Diversity, Equity, and Inclusion: A Patient-Centric Framework and Multifaceted Strategy in a Nationwide Online Behavioral Pain Treatment Study
1 in 3 Americans suffer from ongoing pain (Yong, 2022), and ethnic and racial minorities are disproportionately affected. Studies have historically failed to capture a diverse sample representative of the US population, causing less generalizable outcomes and exacerbating healthcare disparities. The PROGRESS study, or Pain Relief with Online Groups that Empower Skills-based Symptom Reduction (Darnall, 2023) testing 1-session Empowered Relief vs. 8-session CBT, enhances DEI by recruiting from 6 national sites (N=1,650 patients) using targeted enrichment strategies and implementing multi-leveled advisory boards engaged at ev...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Brittany Dorsonne, Arayam Y Hailu, Matthias Cheung, Emma Adair, Jessica Clifton, Elizabeth Heggan, Gabrielle Riazi, Wendy Andrews, Calia Morais, Regina Greer-Smith, Ting Pun, Neely Williams, Heather P. King, Maisa Ziadni, Sean Mackey, Beth Darnall Source Type: research
Impact of Childhood Trauma History on Treatment Responses to Psychosocial Interventions for Chronic Low Back Pain: A Randomized Controlled Trial
This study aimed to understand how childhood trauma impacts behavioral pain treatment response. Participants (N=218; Female 50%; Mage= 49.78; SDage= 14.06) were randomly assigned to three groups: an 8-week Cognitive Behavioral Therapy (CBT; N=75), a single-session of Empowered Relief (ER; N=76), and a two-hour session of Health Education (HE; N=67). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Samsuk Kim, Dokyung Sophia You, Sean C. Mackey, Beth D. Darnall Source Type: research
Implementation of Pain Management Algorithm in Hospitalized Solid Tumor Patients
Inadequately treated pain impacts hospitalized solid tumor patients in a large teaching hospital. The unit has not met the department ’s pain management goals, and patient satisfaction surveys show an opportunity for improvement. The aim of this project was to implement the National Comprehensive Cancer Network’s (NCCN) pain management algorithm to promote evidence-based pain management and improve patient-stated pain scores. This project targeted patients on one solid tumor service who were not being treated by palliative care, were not in the intensive care unit, and did not receive continuous analgesic infusions. (S...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Aliki Argiropoulos, Mikaela Olsen, Maria Robinson, Kristin Seidl Source Type: research
Investigation of Inflammation in Fibromyalgia After a Lipopolysaccharide-Induced Immune Response
Fibromyalgia (FM) is a debilitating chronic pain disorder characterized by widespread musculoskeletal pain. The exact cause of FM is unknown, but current research suggests that an overactive immune response may be involved. The purpose of this study was to examine pathophysiological responses to a low-level immune insult, using in-vivo administration of lipopolysaccharide (LPS). Thirteen women with FM and 13 age-matched healthy controls (HC) completed the study. Blood samples were collected before participants received 0.3ng/kg or 0.4ng/kg endotoxin and 3 hours after. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Matthew McDaniel, Indonesia A. Jordan, Sophia Fox, Jarred Younger Source Type: research
Ketamine-Induced Anaphylactic Shock During Prophylactic Mastectomy
We present the case of a 35-year-old woman undergoing bilateral prophylactic mastectomy that developed intraoperative anaphylaxis to first exposure of ketamine. A literature search using PubMed and key words “ketamine”, “anaphylaxis”, and “anaphylactic shock” was conducted along with a description of the clinical case. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Catherine Chia, Kristine Calhoun, Michele Curatolo, Preetma Kooner Source Type: research
Long-Term Safety and Efficacy of Esreboxetine for the Treatment of Fibromyalgia
Several unmet needs exist for fibromyalgia treatment including long-term efficacy. Esreboxetine is an extended-release, potent and highly-selective norepinephrine reuptake inhibitor under investigation for fibromyalgia. Esreboxetine has demonstrated efficacy and safety in placebo-controlled fibromyalgia trials ranging in duration from 8-14 weeks (Arnold, 2010; Arnold, 2012). This open-label study evaluated long-term treatment of flexibly dosed esreboxetine (4-10 mg) in adult patients with fibromyalgia. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Lesley M. Arnold, Philip J. Mease, Zachariah Thomas, Allen Moton, Herriot Tabuteau Source Type: research
Mean of Daily Versus Single Week Recall-Based Pain Quality Assessments in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN) Trials: Implications for Assay Sensitivity
Patients with neuropathic pain present with different pain qualities. Each is usually assessed using single ratings in randomized clinical trials (RCTs). To our knowledge, no studies have investigated whether means of daily pain quality assessments would provide better assay sensitivity (i.e., more sensitive to treatment effects) than single week recall-based assessments. This secondary analysis used data from participants who reported ³4 out of 10 severity for hot/burning pain, sharp/shooting pain, and/or cramping at baseline in a RCT of transcutaneous electrical nerve stimulation for CIPN (N=88). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Madelaine S. Rangel, Soroush Besharat, Michael B. Sohn, Brian Burnette, Lori Francar, Carla Jorgensen, Karen Mustian, Gary Morrow, Michael P. Mc Dermott, Mark Jensen, Jennifer S. Gewandter Source Type: research
Personalized Trial Outcomes for Painful Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Strategy to Increase Assay Sensitivity
Very few treatments have demonstrated efficacy for CIPN in clinical trials. Patients with painful CIPN present with varying painful sensory qualities. We hypothesize that personalized endpoints that incorporate each participants ’ most severe or bothersome painful qualities would provide a more assay sensitive endpoint than an endpoint that includes multiple pain qualities, regardless of whether all participants endorse them. This secondary analysis included data from participants who reported ³4 out of 10 severity for h ot/burning pain, sharp/shooting pain, and/or cramping (N= 80) at baseline in a RCT of transcutaneous...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Karim Saab, Umang Gada, Eva Culakova, Carla Jorgensen, Dhaval Shah, James D. Bearden III, Karen Mustian, Gary Morrow, Jennifer S. Gewandter Source Type: research
Safety and Tolerability of Esreboxetine in Fibromyalgia: Results from an Open-label, Flexible-dose, Phase 3 Extension Study
Currently, there are only three FDA-approved medications for the treatment of fibromyalgia. Real-world studies demonstrate that these medications are frequently discontinued within 6 to 12 months of initiation, often due to tolerability concerns. This leaves patients with limited treatment options for this debilitating condition. Esreboxetine is a novel, extended-release, potent and highly-selective norepinephrine reuptake inhibitor under investigation for the treatment of fibromyalgia in adults. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Lesley M Arnold, Philip J Mease, Zachariah Thomas, Allen Moton, Herriot Tabuteau Source Type: research
Year Three Update: Clinical Trials for Non-addictive Pain Therapeutics Conducted Through Early Phase Pain Investigation Clinical Network
The widespread use of opioids to treat acute and chronic pain contributed to the approximately 10.3 million people aged 12 years and older in the United States in 2018 who misused opioids. The NIH HEAL Initiative launched the Early Phase Pain Investigation Clinical Network (EPPIC-Net) to accelerate clinical trials of non-addictive pharmacologic/non-pharmacologic therapeutics ( “assets”) for pain conditions of high unmet need. EPPIC-Net provides infrastructure for conducting high quality, multi-site phase 2 clinical trials and has the capacity to run concurrent trials. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kevin Jones, Marlene Peters Lawrence, Rebecca Hommer, Clinton B Wright Source Type: research
A 4-Minute Mindful Pain Management Intervention Delivered in an X-Ray Waiting Room Decreased Patients ’ Pain: Results from a Randomized Controlled Trial
Idle gaps exist in many medical care pathways that could be leveraged for therapeutic benefit. Time in the clinic waiting room is one such example. With brief mindfulness interventions capable of quickly decreasing clinical symptoms, embedding a brief mindfulness intervention in a clinic waiting room has the potential to transform idle time into time for healing. The purpose of this single-site, two-arm, randomized controlled trial was to examine whether a 4-minute, audio-recorded, mindful pain management intervention could decrease patients ’ pain and anxiety while waiting for an x-ray in an orthopedic walk-in clinic. (...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Adam W. Hanley, Allison Davis, Phillip Worts, Carli Zegers Tags: Complementary and Integrative Pain Research Source Type: research
Developing A Group Biofeedback Intervention for Patients with Hypermobile Ehlers-Danlos Syndrome: Fostering Accessibility in Pain Interventions
Hypermobile Ehlers-Danlos Syndrome (hEDS), characterized by joint instability and connective tissue fragility, is often accompanied by chronic pain and poses unique challenges to both patients and practitioners. Holistic approaches can be beneficial in addressing complex persistent pain. Biofeedback, a non-invasive intervention, can guide patients in exercising voluntary control over autonomic physiologic responses involved in pain. Most methods of biofeedback require specialized training, software, and equipment and must be delivered in the one-on-one context of patient and clinician. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Lindsay G. Flegge, Jill C. Penman Source Type: research
