Pain Rating is Worth a Thousand Words: Nocebo Hyperalgesia Induced by Verbal  Modeling Prevails Over the Effects of Symbolic Modeling and Verbal Suggestion
This study compares the effectiveness of verbal modeling, symbolic modeling, and verbal suggestion in inducing nocebo hyperalgesia. It is the first study to examine the contribution of stress to observationally induced nocebo hyperalgesia. This study ’s experimental groups represented various sources of social information: a group of people participating in the study (verbal modeling), a single participant (symbolic modeling), and an experimenter (verbal suggestion). During the experiment, participants received electrocutaneous stimuli at the same intensity, some of which were applied with a nocebo (sham device). (Source...
Source: The Journal of Pain - December 4, 2023 Category: Materials Science Authors: Daryna Rubanets, Julia Badzi ńska, Joanna Kłosowska, Przemysław Bąbel, Elżbieta A. Bajcar Source Type: research

Pain rating is worth a thousand words. Nocebo hyperalgesia induced by verbal modeling prevails over the effects of symbolic modeling and verbal suggestion
This study compares the effectiveness of verbal modeling, symbolic modeling, and verbal suggestion in inducing nocebo hyperalgesia. It is the first study to examine the contribution of stress to observationally induced nocebo hyperalgesia. This study ’s experimental groups represented various sources of social information: a group of people participating in the study (verbal modeling), a single participant (symbolic modeling), and an experimenter (verbal suggestion). During the experiment, participants received electrocutaneous stimuli at the same intensity, some of which were applied with a nocebo (sham device). (Source...
Source: The Journal of Pain - December 4, 2023 Category: Materials Science Authors: Daryna Rubanets, Julia Badzi ńska, Joanna Kłosowska, Przemysław Bąbel, Elżbieta A. Bajcar Source Type: research

Patient Expectations and Therapeutic Alliance Affect Pain Reduction following Lidocaine Infusion in an Interdisciplinary Chronic Pain Clinic
Pain experience is affected by both ascending nociceptive signals and descending modulation. Expectations can affect pain experience and augment treatment-induced analgesia through descending inhibitory modulation of pain. This open-label, prospective cohort study examined the association between participant expectation ratings and pain reduction in adult participants with chronic pain receiving an intravenous lidocaine infusion. We aimed to explore whether: 1) participants ’ expectations of treatment efficacy were associated with pain reduction over 8 weeks after infusion; and 2) participants’ therapeutic alliance was...
Source: The Journal of Pain - December 4, 2023 Category: Materials Science Authors: Landon T. Montag, Etienne J. Bisson, Scott Duggan, Thomas Gregory, Greg Murphy, Ian Gilron, Rosemary Wilson, Tim V. Salomons Source Type: research

The Association of Prescribed Opioids and Incident Cardiovascular Disease
Opioid prescribing remains common despite known overdose-related harms. Less is known about links to non-overdose morbidity. We determined the association between prescribed opioid receipt with incident cardiovascular disease using data from the Veterans Aging Cohort Study, a national prospective cohort of Veterans with/without HIV receiving Veterans Health Administration care. Selected participants had no/minimal prior exposure to prescription opioids, no opioid use disorder, and no severe illness one year after the study start date (baseline period). (Source: The Journal of Pain)
Source: The Journal of Pain - November 27, 2023 Category: Materials Science Authors: Minhee L. Sung, Svetlana K. Eden, William C. Becker, Stephen Crystal, Meredith S. Duncan, Kirsha S. Gordon, Robert D. Kerns, Suman Kundu, Matthew Freiberg, Kaku A. So-Armah, E. Jennifer Edelman Source Type: research

Effects of lockdown restrictions and impact of anxiety and depression symptoms in people with chronic pain during the Covid-19 pandemic: A 13-wave longitudinal study
In early 2020, countries across the world imposed lockdown restrictions to curb the spread of the Covid-19 coronavirus. Lockdown conditions, including social and physical distancing measures and recommended self-isolation for clinically vulnerable groups, were proposed to disproportionately affect those living with chronic pain, who already report reduced access to social support and increased isolation. Yet, empirical evidence from longitudinal studies tracking effects of prolonged and fluctuating lockdown conditions, and potential psychological factors mediating effects of such restrictions on outcomes in chronic pain po...
Source: The Journal of Pain - November 27, 2023 Category: Materials Science Authors: Charlotte Krah é, Christopher Brown, Hannah Twiddy, Bernhard Frank, Eleanor Brian, Turo Nurmikko, Andrej Stancak, Nicholas Fallon Source Type: research

Masthead
(Source: The Journal of Pain)
Source: The Journal of Pain - November 24, 2023 Category: Materials Science Source Type: research

Editorial Board
(Source: The Journal of Pain)
Source: The Journal of Pain - November 24, 2023 Category: Materials Science Source Type: research

Table of Contents
(Source: The Journal of Pain)
Source: The Journal of Pain - November 24, 2023 Category: Materials Science Source Type: research

EGFR tyrosine kinase inhibitor lazertinib activates a subset of mouse sensory neurons via TRPA1
In this study, we investigated whether and how lazertinib affects peripheral sensory neurons. (Source: The Journal of Pain)
Source: The Journal of Pain - November 24, 2023 Category: Materials Science Authors: Hayun Kim, Dahee Roh, Seog Bae Oh Tags: Original Reports Source Type: research

Myeloid Cell Association with Spinal Cord Injury-Induced Neuropathic Pain and Depressive-like Behaviors in LysM-eGFP Mice.
Spinal cord injury (SCI) affects ~500,000 people worldwide annually, with the majority developing chronic neuropathic pain. Following SCI, approximately 60% of these individuals are diagnosed with comorbid mood disorders, while only ~21% of the general population will experience a mood disorder in their lifetime. We hypothesize that nociceptive and depressive-like dysregulation occurs after SCI and is associated with aberrant macrophage infiltration in segmental pain centers. We completed moderate unilateral C5 spinal cord contusion on LysM-eGFP reporter mice to visualize infiltrating macrophages. (Source: The Journal of Pain)
Source: The Journal of Pain - November 23, 2023 Category: Materials Science Authors: Jonathan H. Richards, Daniel D. Freeman, Megan Ryan Detloff Tags: Original Reports Source Type: research

Perioperative Opioid Use and Dosage Trajectories Vary Depending on Pain Outcome Classification and Bodily Pain in Patients who Catastrophize About Their Pain: A Secondary Analysis of a Randomized Trial in Knee Arthroplasty
Opioid use and dosage following knee arthroplasty (KA) has not been reported for subgroups with persistent moderate pain versus rapidly improving mild pain, externally validated from prior work. We determined if opioid use and dosage varied for persons classified into these externally validated subgroups. A secondary purpose determined if bodily pain scores associated with outcome subgroup. This was a secondary analysis of a prospective no-effect randomized clinical trial conducted on 384 participants with pain catastrophizing and scheduled for KA. (Source: The Journal of Pain)
Source: The Journal of Pain - November 23, 2023 Category: Materials Science Authors: Daniel L. Riddle, Levent Dumenci Source Type: research

Temporal summation of the thermal grill illusion is comparable to that observed following noxious heat
The thermal grill illusion (TGI) describes a peculiar or even painful percept caused by non-noxious, interlaced warm and cold stimuli. It involves the glutamatergic system and is affected in putatively nociplastic syndromes such as fibromyalgia. The glutamatergic system is also involved in wind-up, that is, the increased activation of spinal neurons following repeated noxious stimulation leading to a temporal summation of perceived stimulus intensity. Here we combined both stimulation methods to further investigate whether non-noxious stimuli as employed in the TGI can lead to a similar summation of perceived stimulus inte...
Source: The Journal of Pain - November 21, 2023 Category: Materials Science Authors: Bj örn Horing, Matthias Kerkemeyer, Christian Büchel Tags: Original Reports Source Type: research

Wireless Transcutaneous Electrical Nerve Stimulation (TENS) for Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Proof-of-Concept Randomized Clinical Trial
Chemotherapy-induced peripheral neuropathy (CIPN) affects approximately 30 to 60% of people who receive neurotoxic chemotherapy. CIPN is associated with impaired quality of life and function and has few effective treatments. This 6-site, subject and assessor-blinded randomized clinical trial (RCT) was designed to assess 1) preliminary efficacy (ie, alpha pre-specified at .2) of a wearable, app-controlled, transcutaneous electrical nerve stimulation (TENS) device for chronic CIPN and 2) feasibility of conducting a confirmatory trial within the National Cancer Institute Community Oncology Research Program (NCORP) (NCT 043674...
Source: The Journal of Pain - November 20, 2023 Category: Materials Science Authors: Jennifer S. Gewandter, Eva Culakova, Jenae N. Davis, Umang Gada, Joseph J. Guido, James D. Bearden, Brain Burnette, Dhaval Shah, Gary R. Morrow, Karen Mustian, Kathleen A. Sluka, Nimish Mohile Source Type: research

Wireless transcutaneous electric nerve stimulation (TENS) for chronic chemotherapy-induced peripheral neuropathy (CIPN): a proof-of-concept randomized clinical trial
Chemotherapy-induced peripheral neuropathy (CIPN) affects approximately 30%-60% of people who receive neurotoxic chemotherapy. CIPN is associated with impaired quality of life and function and has few effective treatments. This 6-site, subject and assessor blinded RCT was designed to assess (1) preliminary efficacy (i.e., alpha pre-specified at 0.2) of a wearable, app-controlled, TENS device for chronic CIPN and (2) feasibility of conducting a confirmatory trial within the NCI Community Oncology Research Program (NCORP) (NCT 04367480). (Source: The Journal of Pain)
Source: The Journal of Pain - November 20, 2023 Category: Materials Science Authors: Jennifer S. Gewandter, Eva Culakova, Jenae N. Davis, Umang Gada, Joseph J. Guido, James D. Bearden, Brain Burnette, Dhaval Shah, Gary Morrow, Karen Mustian, Kathleen Sluka, Nimish Mohile Source Type: research

Examination of conditioned pain modulation in myofascial TMD with consideration of temporal summation
This study aimed to: (1) examine whether women with mTMD demonstrated efficient CPM compared to controls; (2) explore the association between independent measures of CPM and TSSP in women with mTMD relative to controls; and (3) whether resulting modulatory profiles differentially predicted pain intensity among cases. (Source: The Journal of Pain)
Source: The Journal of Pain - November 20, 2023 Category: Materials Science Authors: Vivian Santiago, Malvin N Janal, Dane B Cook, Karen G Raphael Tags: Original Reports Source Type: research