Mast-Cell-Derived Proteases Mediate Resolution of Inflammatory Pain in Mice

Immune cells play a critical role regulating the transition from acute to chronic pain, however, while the initiation of inflammatory pain is relatively understood (Ji, 2016), the mechanism behind the resolution is unclear. Mast cells reside in the skin and because of their proximity to sensory nervous, a tight interplay with nociceptors has long been proposed (Hendriksen, 2017; Morellini, 2018; Mittal, 2019). These interactions may be beneficial or detrimental, suggesting their participation in pain modulation.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research