Surgical Rodent Model of Osteoarthritis Alters Joint Structure, Tactile Sensitivity, and the Brain
Osteoarthritis (OA) is a debilitating and painful joint disorder with a significant impact on patient ’s lives. However, the effects of OA on pain-processing regions in the brain are poorly understood. To address this gap, the current study investigates joint remodeling, pain-related behavior, and brain remodeling in a surgical rodent model of post-traumatic osteoarthritis. Male and female Fischer -344 rats (18-19 months) received either a skin-incision (n=6 male, n=10 female) or medial meniscus transection plus medial collateral ligament transection (MMT+MCLT) (n=5 male, n=11 female) surgery. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Jacob L. Griffith, Pedro Valdes Hernandez, Yenisel Cruz-Almeida, Marcelo Febo, Kyle D. Allen Source Type: research
Visual Quantitative Sensory Testing Provides Transdiagnostic Window into Behavioral and Functional Neural Correlates of Nociplastic Pain
Multisensory hypersensitivity to painful and non-painful stimuli, including light, is common among individuals with nociplastic pain. However, as nociplastic pain is often superimposed upon nociceptive and neuropathic pain, we hypothesized that the degree of nociplastic pain would predict the amount of sensory hypersensitivity in many chronic pain states. To assess this hypothesis, the present study investigated associations between evoked visual sensitivity, brain activation patterns, and clinical outcomes in participants with fibromyalgia (FM,n=45) - the prototypical nociplastic pain condition - and osteoarthritis (OA,n=...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Noah Waller, Chelsea Kaplan, Andrew Schrepf, Eric Ichesco, Richard Harris, Daniel Clauw, Steven Harte Source Type: research
A Patient and Clinician Focus Group Study to Inform the Design and Clinical Integration of a Wearable Activity Monitor to Support Chronic Low Back Pain Management
Remaining physically active is a recommended component of chronic low back pain (cLBP) management. In clinic, physical activity is typically assessed by retrospective self-evaluation, and may be supplemented by objective measures. However, due to technological burdens faced by patients and clinicians, current objective assessment methods of daily physical activity are not suitable for routine care. To address this, we are developing a discreet, single-use wrist-worn activity monitor to support cLBP clinical management. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Daniel Whibley, Sonia Sharma, Kristi Pickup, Anna Kratz, Andrew Schrepf, Steven Harte, Grant Kruger Tags: Pain, Movement, and Rehabilitation Science Source Type: research
Associations Between Comorbid Pain Sites and Pain Bothersomeness with Pain Impact in Adults with Symptomatic Lumbar Spinal Stenosis: Baseline Data Analysis of the Lumbar Stenosis Prognostic Subgroups for Personalizing Care and Treatment Study
We describe the associations of the number of comorbid pain sites and cumulative bothersomeness of those sites with pain impact. This cross-sectional study uses baseline data from a cohort of adults aged ≥50 seeking non-surgical care for LSS at two spine clinics. Comorbid pain locations are summed from a self-reported checklist of 9 locations (range 0-9), and bothersomeness at each site is rated between 0-2 (range 0-18, higher indicates greater bothersomeness). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Natasha L. Parman, Eric N. Meier, Janna L. Friedly, Pradeep Suri, Maggie E. Horn, Colleen A. Burke, Ayumi Saito, Patrick J. Heagerty, Jeffrey G. Jarvik, Adam P. Goode, Amy M. Cizik, Monica Smersh, Sandra K. Johnston, Rebecca Fillipo, Sean D. Rundell Source Type: research
Association Between Localized Achilles Tendon Movement-Evoked Pain and Core Health-Related Domains in Individuals with Chronic Achilles Tendinopathy
Current understanding of tendinopathy extends beyond a localized pain diagnosis and includes a multidimensional patient perspective. The purposes of this study were to 1) identify targetable core health-related domains for tendinopathy (disability, psychological variables, pain, factors associated with quality of life) and 2) establish associations between localized Achilles tendon movement-evoked pain (MEP) and core health-related domains in individuals with chronic Achilles tendinopathy (AT). 24 individuals with chronic AT (50% female, Age: 43.9 ±16.6, BMI: 30.2±6.7kg/m2, Duration of pain: 38.7±39.1months) and 24 cont...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Andrew A. Post, Tim Fleagle, Cesar de Cesar Netto, Katherine E. Hadlandsmyth, Jason M. Wilken, Kathleen A. Sluka, Ruth L. Chimenti Source Type: research
Decoding Pain Chronicity in Electronic Health Records: Feasibility of Automated Annotation of Pain Chronicity in Chronic Low Back Pain Patients
Chronic low back pain is a severe health condition with underlying biopsychosocial factors that make diagnosis difficult and pain chronicity has been shown to be an important variable for studying patient outcomes. However, chronicity is not typically recorded in Electronic Health Records (EHRs) and currently needs to be manually annotated by experts. Using a dataset from an interdisciplinary spine clinic at UCSF consisting of 394 patients manually annotated with pain chronicity by clinical experts, our study has two goals: 1) study the relationship between expert-annotated chronicity and other important variables and 2) s...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Simran A. Kanal, Jeannie F. Bailey, Jeffery Lotz, Aaron Scheffler, Thomas A. Peterson Source Type: research
Gait Analysis for the Study and Quantification of Neuropathic Lower Limb Pain
Evaluation of pain frequently relies on subjective scales such as the Numerical Rating Scale. Supplementing such measures with objective endpoints can provide a deeper assessment of acute and chronic pain. In the present study, we outline a protocol to pilot gait analysis as an objective measure of pain using the Tekscan Strideway, a modular gait analysis platform that detects highly sensitive pressure measurements and spatiotemporal parameters taken from a full gait cycle. We posit that individuals with foot pain will exhibit abnormal gait and altered pressure loading, correlating with patient-reported outcome measurement...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sad é Orejobi, Michael Iadarola, Misha Bačkonja, Matthew Sapio, Andrew Mannes Source Type: research
Genetic Architecture of Chronic Back Pain: A Multi-Ancestry Genome-Wide Association Study in The Million Veteran Program
This multi-ancestry meta-analysis of genome-wide association studies investigated the genetic factors underlying chronic back pain (CBP) in a large and diverse sample from the Million Veteran Program. A total of 553,601 Veterans of African (19.2%), European (72.6%) and Hispanic (8.2%) ancestry were included. The results revealed 87 loci (67 novel) with 90 independent variants. 85 variants had available summary statistics in (Bjornsdottir, 2023). 57 replicated at the nominal significance threshold (p (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Ian B. Stanaway, Pradeep Suri, Niloofar Afari, Daniel Dochtermann, Saiju Pyarajan, Eric J. Roseen, Marianna Gasperi Source Type: research
Impact of an Individualized Low-to-Moderate Exercise Task on Post-Exertional Malaise in Post-Acute Sequelae of SARS-CoV-2 Infection and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This study examined tolerance to a tailored low-to-moderate intensity exercise task using age-predicted maximal heart rate guided by symptom-based intensity modifications in individuals with PASC and ME/CFS. Thirty individuals with PASC, ME/CFS, and controls completed a bout of whole-body exercise on an upright cycle ergometer for 25-minutes. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Giovanni Berardi, Adam Janowski, Samuel McNally, Kathleen Sluka Source Type: research
Movement Evoked Pain Is Associated with Reaction Time but Not Stability During a Forward Choice-Reaction Hop-to-Stabilization Task Among Individuals with Chronic Ankle Instability
Pain during a neurocognitive hop-to-stabilization (HTS) task may contribute to poor performance and slower reaction times, which are two factors that can increase the risk for injury among individuals with chronic ankle instability (CAI). The purpose of this preliminary analysis was to explore the relationship between movement-evoked pain (MEP), reaction time, and stability during a neurocognitive HTS task among those with CAI. Twelve young-adults with self-reported CAI (66% female, ages 18-35 year) volunteered to participate. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kyle B. Kosik, Ke ’La Porter, Matthew C. Hoch, Danielle M. Torp Source Type: research
Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-Acute Sequelae of Severe Acute Respiratory Syndrome 2 Infection
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-acute sequelae of SARS-CoV-2 infection (PASC) are complex clinical conditions sharing several symptoms hallmarked by post-exertional malaise (PEM). PEM is a severe exacerbation of symptoms after minor physical or mental exertion starting 6-24 hours after activity and can last for days or even weeks. Little is known about the relationship between PEM severity and fatigue, pain, function, and psychological measures. Our purpose was to compare two methods of collecting PEM data: (1) DePaul Symptom Questionnaire – PEM (DSQ-PEM) taken at baseline and (2) a s...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kathleen A. Sluka, Adam J. Janowski, Giovanni Berardi, Samuel McNally Source Type: research
Prolotherapy As Treatment for Particulate Steroid-Induced Soft-Tissue Necrosis After Sacroiliac Joint Injection: A Case Report
We present a 51-year-old woman with history of low back pain previously treated with two particulate steroid injections of the left sacroiliac joint, resulting in a 5cm x 4 cm x 1.4 cm atrophic indent with intact but hypopigmented skin. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Vivian Wung, Peter J. Lee, Cole M. Crosby, Elisabeth B. Powelson Source Type: research
Spinal Cord Stimulation for Phantom Limb Pain Improves Upper Limb Myoelectric Prosthesis Use
We describe a case of PLP after transhumeral amputation with targeted muscle reinnervation. The PLP was complicated by involuntary muscle contractions in the residual limb which was a barrier to effective myoelectric prosthetic limb use. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Lauren E. Penz, F. Clay Smither, Jonathan M. Hagedorn Source Type: research
Use of Ultrasound-Guided Tenotomy and Debridement in Chronic Achilles Tendinopathy: A Prospective Study
Achilles tendinopathy (AT) is a prevalent musculoskeletal pain condition characterized by activity-related heel pain, elevated pain-related psychological factors, and decreased function. Although exercise is recommended as a front-line treatment for AT, up to 60% of individuals experience persistent pain and could benefit from the availability of second-line treatment options. Ultrasound-guided tenotomy and debridement (USGTD) is a minimally invasive treatment for individuals who do not respond to first-line treatments, yet the impact on pain, psychological factors, and function remains insufficiently studied. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Timothy R. Fleagle, Ruth L. Chimenti, Jessica Danielson, Ryan Kruse, Mederic M. Hall Source Type: research
A Preliminary Investigation of Pain Experience and Mental Health in Children with Cerebral Palsy
Chronic pain is common in children with cerebral palsy (CP); yet little is known about relationships between chronic pain and internalizing disorders in children. The purpose of this preliminary investigation was to examine relationships between chronic pain, pain interference, and mental health in children with CP. The Brief Pain Inventory – Pain Interference Short Form was used to assess pain interference with activities of daily living, the Dalhousie Pain Interview was used to assess chronic pain, and the Behavioral Risk Factor Surveillance System (BRFSS) survey was used to assess mental health factors. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Allison Corlett, Alyssa Merbler, Anna Reimann, Chantel C Burkitt, Frank J Symons Tags: Pediatric Pain Source Type: research
