Spinal Cord Expression and Function of Complement C5aR1 Receptor in Neuropathic Pain

Chronic pain affects approximately 100 million Americans and only a minority of patients experience satisfactory relief of their pain with currently available pharmaceutics. One type of chronic pain is caused by direct injury to the nerve called neuropathic pain, which affects ~10% of the overall population. Despite the prevalence, the underlying mechanisms of neuropathic pain are not well-defined, and better understanding of the mechanisms that promote central sensitization after injury could lead to better treatment of this condition.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research