Investigating The Role of The Parabrachial Nucleus to Central Amygdala Pathway in The Transition from Acute to Chronic Pain in a Mouse Model of Neuropathic Pain

The parabrachial nucleus (PbN) transmits nociceptive information from the spinal cord to the brain. The central amygdala (CeA) modulates emotions and pain and is a target of the PBN. Potentiation of synaptic transmission in the PbN-to-CeA pathway after injury has been shown in different rodent pain models. Further studies demonstrated that this pathway participates in escape, aversion, and injury-induced hypersensitivity. However, previous studies only evaluated early time-points following injury.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research