Therapeutic Potential of a Plant-Based Diet in Reducing Pain and Tumor Growth
Over half of women diagnosed with ovarian cancer report having disease-related pain and traditional cancer therapies cause negative side effects, including pain. Over the last several decades, there have been minimal improvements in the treatment of cancer pain. A high-quality, nutrient-dense diet is associated with positive outcomes in various cancers, and quality of life is positively impacted by a healthy dietary intervention. However, studies looking at the interaction between diet, cancer, and pain are severely lacking. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Stacie K. Totsch, Lyse A. Norian, Rebecca C. Arend, Robert E. Sorge Source Type: research
Three-Dimensional Morphological Analysis of Meningeal Macrophages Over Time Using In Vivo Two-Photon Microscopy
As the second most disabling illness worldwide, migraine is a highly prevalent neurological disorder characterized by painful headaches. The meninges represent a primary site of migraine pathophysiology, and the contribution of meningeal immune cells to this disease has become increasingly apparent. Through the release of cytokines, chemokines, and other mediators, immune cells can modulate pain signaling pathways in nociceptive neurons. Additionally, nociceptive neurons can modulate immune cell activity through the release of neuropeptides from their peripheral terminals. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Talia Adi, Keith J. Kaufman, Ross S. Williamson, Michael S. Gold Source Type: research
Treatment of Compound 968 and CU1015 Reduces Chemotherapy-Induced Peripheral Neuropathy in CD-1 Mice
Chemotherapy-induced peripheral neuropathy (CIPN) affects millions of patients, substantially impacting their quality of life. However, there are few effective treatments available for alleviating CIPN. Therefore, discovering new approaches to manage neuropathic pain is in high medical demand. Compound 968 (C968) and CU1015, both identified as glutaminase inhibitors with applications in cancer therapy, have shown promise in enhancing the anti-cancer activities of chemotherapy drugs in previous studies. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Wei Lei, Sid L. Sagna, Michael K. Thompson, Xin Chen, Tuoen Liu Source Type: research
Unraveling The Role of CGRP Receptor-Expressing Neurons in The Central Amygdala: Insights Into Neuropathic Pain Mechanisms and Behavioral Responses
The central nucleus of the amygdala (CeA) is a hub for diverse neuronal populations influencing various behavioral responses. While previous research has emphasized the role of calcitonin gene-related peptide (CGRP) signaling in CeA synaptic plasticity and its impact on pain-related behavior, the specific functions and contributions of CeA neurons expressing CGRP receptors (CGRPR) in pain processing have remained unclear. Our investigation reveals that, in a neuropathic pain model, CGRPR-expressing CeA neurons co-localize with phosphorylated extracellular signal-regulated kinase (pERK), a marker of pain-related plasticity....
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sudhuman Singh, Torri D. Wilson, Benjamin Neugebauer, Ana Danko, Sarah Chaudhry, Jenny Lin, Spring Valdivia, Yarimar Carrasquillo Source Type: research
A Comprehensive Pain-Related Risk And Protective Index And Machine Learning Brain Age Gap
We reported that greater chronic pain severity and socioenvironmental risk and lower biobehavioral/psychosocial resilience are associated with higher allostatic load across multiple measures. The purpose of this study was to examine the relationship between a combined measure of chronic pain, socioenvironmental status, and biobehavioral/psychosocial resilience with a measure of allostatic load, predicted-chronological brain age gap (BAG). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Angela Mickle, Jared J. Tanner, Udell Holmes, III, Brittany Addison, Kenia Rangel, Josue Cardoso, Cynthia Garvan, Roland Staud, Hrishikesh Deshpande, Song Lai, Adriana Addison, David Redden, Burel R. Goodin, Catherine C. Price, Roger B. Fillingim, Kimberl Tags: Clinical and/or Translational Science Source Type: research
A Pilot Investigation of the Relationship Between Hair Cortisol Levels, Perceived Stress, and Emotional Functioning in Female Patients Across the Lifespan with Chronic Postsurgical Pain
Hair cortisol concentration (HCC) has been identified as a biomarker for perceived stress correlating with negative psychological outcomes like anxiety and depressive symptoms in healthy individuals. However, in chronic pain populations, evidence is mixed with little consensus about the relationship between these variables and even less is known about HCC as a risk factor for the development of chronic postsurgical pain (CPSP). The current study seeks to elucidate the relationships between HCC and perceived stress and emotional functioning. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Margaret Moreland, Caitlin Curry, Madison VanSickel, Anthony Wang, Ziyan Wu, Siya Marwah, Christine B. Sieberg Source Type: research
Adipose-Derived miR-133a-3p And Its Role in Mechanical Sensitivity in Chronic Primary Pain Conditions
To identify pain-relevant miRNAs downstream of beta adrenergic receptor ( βAR) activation and determine their functional effects in chronic primary pain conditions (CPPCs). Rats received peripheral delivery of the β2- and β3AR antagonists ICI-118,511 (1.5mg/kg/day) and SR59230A (1.67 mg/kg/day) alongside systemic delivery of the catechol-o-methlytransferase inhibitor O R486 (15mg/kg/day) or vehicle over 14 days (N=20). RNA sequencing shows that OR486 treatment decreased levels of miR-133a in circulation, and this downregulation was prevented by βAR antagonism. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Nathaniel P. Hernandez, Jiegen Chen, Xin Zhang, Yaomin Wang, Xianglong Gao, Brittney P. Ciszek, Matt Kanke, Mohamad Karaky, Marguerita E. Klein, Praveen Sethupathy, Luda Diatchenko, Andrea G. Nackley Source Type: research
An Examination of Psycho-Behavioral Risk and Resilience in People with Chronically Painful Knee Osteoarthritis
Knee osteoarthritis (OA) is a common chronic condition that often results in high levels of pain severity and functional impairment. People with chronic pain tend to have poor sleep and are at greater psychological risk for experiencing persistent negative mood states. Additionally, measurements of psychological resilience also tend to be lower in people with knee OA. However, there are still mixed findings within the literature as to the exact relationships between psychological risk/resilience, sleep quality, pain and functioning in people with chronic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Daniel A. Kusko, Pavithra A. Thomas, Adriana Addison, Tammie L. Quinn, Cesar E. Gonzalez, Kimberly T. Sibille, Roger B. Fillingim, Robert E. Sorge, Burel R. Goodin Source Type: research
Associations Between Gender Identity, Depression, And Pain Processing in Cisgender and Transgender Individuals
Existing literature has primarily focused on sex differences in pain perception in pain-free populations. However, no studies have used experimental pain testing in cisgender and transgender individuals to assess gender differences in pain processing. Transgender individuals are disproportionately affected by mental-health disparities, which may further impact their response to painful stimuli. The purpose of this study is to examine whether gender differences exist in quantitative sensory testing (QST) across cisgender men (CM), cisgender women (CW), transgender men (TM), and transgender women (TW). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Caroline K. Webb, Samantha Q. Stocking, Shruti R. Gunapati, Nathaniel M. Goldfeiz, Ayona Roychowdhury, Stacie K. Totsch, Tammie L. Quinn, D. Leann Long, Edwin N. Aroke, Mieke B. Thomeer, Lyse A. Norian, Burel R. Goodin, Robert E. Sorge Source Type: research
Autonomic Stress Dysregulation in Temporomandibular Disorders with Multisystem Manifestation – A Pilot Feasibility Study
Temporomandibular disorders (TMD) are a major group of facial pain conditions that affects 12 million U.S. adults. Multisystem manifestations with co-existence of body pain disorders, psychological issues, and poor sleep quality are common in chronic TMD. Altered autonomic functions have been observed in individuals with multisystem manifestation prior to developing TMD. Because the autonomic abnormalities often precede organ system dysfunction, it is important to systemically evaluate autonomic functions in those with multisystem manifestations. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Hong Chen, Jennifer Sukalski, Mark W Chapleau, Steven Levy Source Type: research
Clinical And Genetic Associations of Perineural Invasion and Pain in Patients with Head and Neck Squamous Cell Carcinoma
This study aims to characterize different pain patterns linked with PNI, its influence on daily functioning, and to gain insight into the molecular changes and pathways associated with PNI-related pain in HNSCC patients. We conducted a retrospective study across three medical centers (n=114), assessing pain phenotypes and their impact on daily functioning using two self-reported pain questionnaires simultaneously. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Maria Daniela Santi, Kesava Asam, Minh Phuong Dong, Gary Yu, Morgan Zhang, Delaney H Sheehan, Carissa M Thomas, Chi T. Viet, Bradley Aouizerat, Yi Ye Source Type: research
Clinically Important Changes and Agreement Among Pain Measurements During Sickle Cell Disease Vaso-occlusive Episodes in The Emergency Department
We aimed to determine minimally clinically important difference (MCID) in pain severity and agreement between the visual analog scale (VAS) and the verbal numeric rating scale (NRS) in people with sickle cell disease experiencing an acute vaso-occlusive episode in the emergency department (ED). In the COMPARE-VOE trial (NCT03933397), participants were administered the VAS (0-100), NRS (0-100), and verbal categorical rating of pain scale (a lot better, a little better, same, a little worse, much worse) every 30 minutes while in the ED. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Mitchell R. Knisely, Huiman Barnhart, Stephanie Ibemere, Paula Tanabe Source Type: research
Decoding Myofascial Pain: Windup Phenomenon as A Key Diagnostic Measure
Myofascial pain syndrome (MPS) is a common musculoskeletal pain disorder with increased prevalence in individuals with comorbidities including cancer, stroke, osteoarthritis, mental health conditions, and more. Despite its prevalence, there is a lack of clinically feasible, evidence-based outcome measures for MPS diagnosis. The windup phenomenon is a frequency-dependent increase in neuronal excitability to input stimuli, facilitating temporal summation of pain that's commonly associated with central sensitization. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Yonathan Assefa, John Srbely, Lynn Gerber, Secili DeStefano, Jay Shah, Siddartha Siikdar Source Type: research
Demographic, Pain, and Functional Characteristics of Participants in the Population-Based Dallas Heart and Minds Study
There are few diverse, population-based cohort studies that have detailed pain phenotypes, including neuropathic pain. This prospective study has currently enrolled participants (n=1,053; age = 61.3 ±9.6 yr) from the Dallas Heart and Minds Study. Participants underwent a battery of testing including questionnaires, metabolic measures, experimental pain assessment, skeletal muscle function, and a graded exercise test to determine hallmark phenotypes associated with pain. Participants were dicho tomized into those who reported no pain (n=381, 36.2%), nociceptive or unclear pain (painDETECT score ≤18) (n=605, 57.5%), and n...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Jason Zafereo, Una E. Makris, Giselle Uwera, Yihun Zeleke, Gregory P Barton Source Type: research
Developing And Testing a Home Quantitative Sensory Testing Tool-Kit – A Pilot Study in Healthy Young Adults
The objective of this study was to develop a home QST (HQST) tool-kit that is safe, easy to use, and detects changes in sensory and pain processing. The HQST tool-kit was developed using inexpensive, portable, and widely available tools that have been tested in adult populations or best mimic LQST equipment. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Don Daniel Ocay, Kimberly Lobo, Angela Kim, Meghan Halpin, Charles Berde Source Type: research
