Multimodal Hypersensitivity Predicts the Development of Widespread Body Pain in Adolescents
Widespread body pain can emerge in adolescence and is a risk factor for chronic widespread pain conditions in adulthood, such as fibromyalgia, that negatively impact quality of life. In this longitudinal study we identified predictors for developing widespread body pain (pain in at least 3/7 sites) across menarche in adolescents. Over pre- and post- menarchal study visits spanning an average of 2.6 years, 178 participants completed a bodymap questionnaire as well as psychosocial questionnaires, quantitative sensory testing (including unpleasant visual and auditory stimuli), and a provoked visceral pain task that measures b...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Emily Burda, Natalie R. Osborne, Sarah E. Darnell, Andrew Schrepf, Lynn Walker, Kevin Hellman, Frank Tu Source Type: research
Prospective Pain Trajectories Among Children with Cerebral Palsy Undergoing Orthopedic Surgery
Many children with cerebral palsy (CP) undergo multiple orthopedic surgeries, which may improve pain or lead to the development of new pain; yet, prospective research is limited. The purpose of this study was to report pain before and after spine fusion and single-event multilevel orthopedic surgery (SEMLS) in children with CP. Parents completed surveys at 5 time points (pre-surgery and post-surgery: 1, 3, 6, 12 months). Moderate-severe pain was defined as pain intensity of 4/10. Chronic post-surgical pain (CPSP) was defined as new pain that developed after surgery or existing pre-surgical pain that worsened by at least 30...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Liz Boyer, Allison Corlett, Aleksys Patterson, Lisa Lykken, Tom Novacheck, Frank J Symons, Chantel C Burkit Source Type: research
Psychometrics of a Fear-Avoidance Measure Adapted for Youth with Concussion: Fear of Concussive Symptoms Questionnaire (FOCSQ)
Fear-avoidance is a risk factor for chronic pain, and recent research suggests fear-avoidance might play a role in prolonged concussion recovery, but standardized measures of fear-avoidance focus on pain rather than broader concussive symptoms. We adapted the Fear of Pain Questionnaire (FOPQ), changing “pain” to “concussive symptoms” and generating parent-proxy and youth-report versions, calling the new scale the Fear of Concussive Symptoms Questionnaire (FOCSQ). We assessed psychometrics of this scale with a sample of N=110 youth with concussion (mean age = 15.1 years, 58% female, 70% Non -Hispanic White, 15% Hisp...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sara Chrisman, Chuan Zhou, Beth Bollinger, Jordan Sahlberg, Jason Mendoza, Alison Brooks, Fred Rivara, Tonya Palermo Source Type: research
Psychosocial Risk Status Impacts Response to a Psychological Treatment for Youth with Functional Abdominal Pain
Functional abdominal pain disorders (FAPD) are common in youth, impacting up to 25% of children worldwide. A subset of youth experience persistent symptoms that impact functioning over the long-term. It has been shown those with clinically elevated levels of concurrent pain, functional disability, and anxiety (a high risk FAPD profile) are at increased risk of persistent disability due to pain. While effective nonpharmacologic treatments such as cognitive behavioral therapy (CBT) are available for FAPD, it is unknown if there are differential treatment effects based on risk status. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Elise Cheney-Makens, Michelle Adler, Samantha Ely, Natoshia R. Cunningham Source Type: research
Role of Sensory Neuron Derived Interleukin 34 in Neonatal Nociceptive Priming
Injury to the developing peripheral nervous system can lead to prolonged hypersensitivity after repeated injury later in life; a phenomenon called neonatal nociceptive priming. After early life injury, peripheral macrophages retain epigenetic modifications and generate a more pro-inflammatory response to subsequent injury contributing to neonatal nociceptive priming. However, it is not known whether sensory neurons themselves establish similar “memories” of early life injury and therefore also contribute to priming. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kourtney L. Sprague, Namrata G.R. Raut, Adam J. Dourson, Aaditya Adlakha, Michael. P. Jankowski Source Type: research
School-Based Pediatric Pain Management: A Systematic Review
Childhood pain can be chronic, common and debilitating and there remains a lack of sufficient subspecialty providers to address this need. A promising solution is training school providers in pediatric pain management strategies. This systematic review highlights studies to date regarding the efficacy of school-based pain management interventions. A comprehensive, replicable, and keyword-based (e.g., terms including mesh terms indicating school based [school, K-12, high school] and behavioral therapy [CBT, biofeedback, relaxation training, and education]) literature search was conducted on PubMed and yielded 2,643 studies....
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Apoorva Ojha, Iris Kouvar-Gough, Natoshia R. Cunningham Source Type: research
The Association Between Positive Childhood Experiences and Psychosocial Functioning in Treatment Seeking Youth with Chronic Pain
This study aims to investigate the relationship between participation in prosocial activities (i.e. sports, drama, or clubs, “positive childhood experiences” [PCEs} based on prior research) and known correlates of poor pain outcomes/toxic stress/AL. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Sydni Britton, Brent Leung, Morgan Mitcheson, Joaqin Moreno, Cameron Talbert, Sarah Nelson Source Type: research
The Integrated Healing Program: Outcomes Associated with a New Intensive Interdisciplinary Pain Program (IIPT) for Teens in Wisconsin
The “Integrated Healing Program” was developed through a novel partnership amongst Children’s Wisconsin, Rogers Behavioral Health, and the Medical College of Wisconsin. The purpose of this study was to evaluate patient-reported outcomes associated with this new IIPT program. The Program was design ed as a Partial Hospitalization Program with integrated physical therapy and medical support. Participants must be 13-18 years and have a medical condition resulting in functional impairment with a decline in health, physical, and emotional quality of life that is exacerbated by psychological factor s. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kimberly Anderson Khan, Keri R. Hainsworth, Kevin E. Berridge, Dalton Kick, Kristine Kim, Gregory Evangelatos, Amanda Quesnell, Michael Collins, Katherine Freimark, Jordan Snetslaar, Jill Wenzel, Steven J. Weisman Source Type: research
User Experience of a Sequenced Cognitive-Behavioral Therapy Internet Intervention for Insomnia and Pain Management in Adolescents with Migraine: A Qualitative Study
Insomnia is recognized as a risk factor for reduced benefit from cognitive-behavioral pain treatment (CBT-Pain) for adolescents with chronic pain. While hybrid treatments have been studied which combine cognitive-behavioral therapy for insomnia (CBT-I) and CBT-pain, outcomes have been highly variable. As an alternate approach, we designed a sequenced internet-delivered insomnia and pain treatment for adolescents with chronic migraine. We sought to understand the user experience of a subset of adolescents who participated in a larger, ongoing efficacy trial. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Daron M. Vandeleur, Natalie Swanda, Katherine S. Slettvet, Joyce George, Tonya M. Palermo, Emily F. Law Source Type: research
A Novel Digital Behavioral Therapy Reduces Fibromyalgia Severity: Results of the PROSPER-FM RCT
We report the effectiveness of FM-ACT from PROSPER-FM (NCT05243511), a pivotal randomized controlled trial (RCT). The trial randomized 275 participants with FM to receive 12 weeks of FM-ACT or an active comparator (Symptom Tracker (ST), designed as a daily symptom tracker/monitor with access to patient education materials). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Dianne M. Shumay, R. Michael Gendreau, Andrea L. Chadwick, Lance M. McCracken, David A. Williams, Daniel J. Clauw, Juan V. Luciano, Yifei Dai, Nicolette Vega, Zunera Ghalib, Kristen Guthrie, Allison C. Kraus, Michael J Rosenbluth, Lesley M. Arnold Tags: Psychosocial Factors and Interventions Source Type: research
Adverse Childhood Experiences, Posttraumatic Stress Disorder, and Symptom Severity Among Patients with Autonomic Disorders and Overlapping Chronic Pain Conditions
We examined whether adverse childhood experiences (ACEs) or current posttraumatic stress disorder (PTSD) predicted symptom severity and quality of life in patients with autonomic disorders like postural tachycardia syndrome (POTS) and associated chronic overlapping pain conditions. Although it is known that trauma exposure and PTSD are associated with persistent sympathetic arousal, little work has examined this relationship in patients with chronic autonomic health conditions. We hypothesized that ACEs and PTSD would be associated with worse autonomic clinical outcomes. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Taylor Crouch, Mary Wells, Madison Maxwell, Tom Chelimsky Source Type: research
Assessing the Association Between Child Maltreatment and Chronic Widespread Pain Adjusting for Familial Confounding: A Co-Twin Control Approach
Many studies document the relationship between child maltreatment (CM) and increased risk of chronic pain. However, estimating the effect of CM on chronic pain is challenging given the threat of familial and other environmental confounding. We used a co-twin control approach to examine the potential causal relationship between self-reported CM (i.e., experiencing any emotional, physical, or sexual abuse, physical neglect, or witnessing family violence) and self-reported chronic widespread pain (CWP) symptom counts after ruling out familial confounding by design. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Alynna G. Summit, Hsien-Chang Lin, Erik Pettersson, Katja Boersma, Brian M. D ’Onofrio, Paul Lichtenstein, Patrick D. Quinn Source Type: research
Associations Between Personality Traits and Pain Severity in Multiple Sclerosis and Fibromyalgia
Chronic pain is a cardinal characteristic of multiple sclerosis (MS) and fibromyalgia (FM). There is growing evidence that personality traits act as determinants of somatic symptoms in various clinical populations. However, little is known about the association between the Five-factor Model of Personality (FFM) – extraversion, agreeableness, conscientiousness, neuroticism, and emotional stability - and pain in MS and FM. In these conditions, it is important to know how personality is related to pain to understand contributors to the pain experience and identify potential treatment targets or factors that can help tailor ...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Duygu Kuzu, Amanda Morris, Anna L. Kratz Source Type: research
Augmented Patient-Clinician Interactions Enhance Inter-Brain Synchrony Between Scalp Regions – a Hyperscan EEG Study
The patient-clinician relationship is central in clinical therapies for chronic pain. Previous research has found that a warm and empathic (augmented) clinical interaction compared to a neutral, business-like (limited) interaction can improve clinical outcomes, though what brain mechanisms are involved is still unknown. We completed an EEG-hyperscanning study (N=34 dyads) with brain EEG signals collected from chronic low back pain patients and clinicians (acupuncturists) during an ecologically valid experimental setting. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Alessandra Anzolin, Arvina Grahl, Seneca Ellis, Lara Gardiner, Jeungchan Lee, Ted Kaptchuk, Vitaly Napadow Source Type: research
Biopsychosocial Risk and Resilience Factors Contributing to Opioid Misuse in Patients with Chronic Pain
Patients with chronic pain are particularly vulnerable to opioid misuse, and this has been attributed to a variety of biopsychosocial factors. Multiple risk and resilience factors impact chronic pain outcomes, but no studies have examined how their unique contribution may predict opioid misuse among patients with chronic pain. Participants in this study consisted of adults (N = 236) with chronic back pain on long-term opioid therapy who participated in a randomized control trial comparing two different nonpharmacologic interventions for the management of chronic pain. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Eric Vilsmark, Robert Edwards Source Type: research
